MCA_03509_1

Protein

Length

434 amino acids

Description: Retrotransposon Ty3/Gypsy Gag-Pol polyprotein

RNA-seq: read pairs 0, FPKM 0.0, percentile rank 0.8% (100% = highest expression)

Protein function

Annotation:			Retrotransposon Ty3/Gypsy Gag-Pol polyprotein
EGGNOG:	0PGPZ		to reverse transcriptase
SGD closest match:	S000003537	TY3B-I	Transposon Ty3-I Gag-Pol polyprotein
CGD closest match:	CAL0000175689	POL93	Pol93p

Protein alignments

	%id	Aln length	E-value
A0A060T683_BLAAD	32.04%	362	5e-43	ARAD1B13926p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B13926g PE=4 SV=1
UniRef50_A0A060T683	32.04%	362	1e-39	ARAD1B13926p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060T683_BLAAD
B5FVH8_YARLI	30.40%	352	3e-33	YALI0E14388p2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E14388g2 PE=4 SV=1
YI31B_YEAST	34.74%	213	7e-24	Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-I PE=3 SV=2
A0A167D9C8_9ASCO	31.36%	169	4e-18	Gag-pol fusion protein OS=Sugiyamaella lignohabitans GN=AWJ20_901 PE=4 SV=1
A0A1D8PC70_CANAL	23.65%	203	5e-13	Pol93p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=POL93 PE=4 SV=1
A0A0J9XCS2_GEOCN	33.33%	102	7e-06	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA10s00604g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9706
Predicted cleavage: 50

Protein family membership

None predicted.

Domains and repeats

Domain
6 - 106
Aspartic peptidase domain (IPR021109)

1 50 100 150 200 250 300 350 400 434

Detailed signature matches

IPR021109

Aspartic peptidase domain
1. G3DSA:2.40.70.10
  
  6 - 106
  
  GENE3D
  G3DSA:2.40.70.10 (G3DSA:2.40.70.10)
2. SSF50630 (Acid prot...)
  
  19 - 105
  
  SUPERFAMILY
  SSF50630 (Acid proteases)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

396 - 434

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:3.10.10.10

184 - 308

GENE3D
G3DSA:3.10.10.10 (G3DSA:3.10.10.10)
G3DSA:3.30.70...

309 - 383

GENE3D
G3DSA:3.30.70.270 (G3DSA:3.30.70.270)
NON_CYTOPLASM... (N...)

27 - 375

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 26

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

19 - 26

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

8 - 18

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 7

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
SSF56672 (DNA/RNA p...)

170 - 344

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
TRANSMEMBRANE (Tran...)

376 - 395

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd00303 (retropepsi...)

20 - 98

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

233 - 344

CDD
cd01647 (RT_LTR)

Residue annotation

Catalytic residue ...

21D

Catalytic residue
21D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

21D

catalytic motif
21D, 22S, 23G
CDD
cd00303 (retropepsin_like)

22S

catalytic motif
21D, 22S, 23G
CDD
cd00303 (retropepsin_like)

23G

catalytic motif
21D, 22S, 23G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

21D

inhibitor binding site
21D, 23G, 25S, 51V, 52H, 53S, 91I
CDD
cd00303 (retropepsin_like)

23G

inhibitor binding site
21D, 23G, 25S, 51V, 52H, 53S, 91I
CDD
cd00303 (retropepsin_like)

25S

inhibitor binding site
21D, 23G, 25S, 51V, 52H, 53S, 91I
CDD
cd00303 (retropepsin_like)

51V

inhibitor binding site
21D, 23G, 25S, 51V, 52H, 53S, 91I
CDD
cd00303 (retropepsin_like)

52H

inhibitor binding site
21D, 23G, 25S, 51V, 52H, 53S, 91I
CDD
cd00303 (retropepsin_like)

53S

inhibitor binding site
21D, 23G, 25S, 51V, 52H, 53S, 91I
CDD
cd00303 (retropepsin_like)

91I

inhibitor binding site
21D, 23G, 25S, 51V, 52H, 53S, 91I
CDD
cd00303 (retropepsin_like)
Active site flap c...

51V

Active site flap
51V, 52H, 53S, 54A, 58R, 59N, 60Q, 61T
CDD
cd00303 (retropepsin_like)

52H

Active site flap
51V, 52H, 53S, 54A, 58R, 59N, 60Q, 61T
CDD
cd00303 (retropepsin_like)

53S

Active site flap
51V, 52H, 53S, 54A, 58R, 59N, 60Q, 61T
CDD
cd00303 (retropepsin_like)

54A

Active site flap
51V, 52H, 53S, 54A, 58R, 59N, 60Q, 61T
CDD
cd00303 (retropepsin_like)

58R

Active site flap
51V, 52H, 53S, 54A, 58R, 59N, 60Q, 61T
CDD
cd00303 (retropepsin_like)

59N

Active site flap
51V, 52H, 53S, 54A, 58R, 59N, 60Q, 61T
CDD
cd00303 (retropepsin_like)

60Q

Active site flap
51V, 52H, 53S, 54A, 58R, 59N, 60Q, 61T
CDD
cd00303 (retropepsin_like)

61T

Active site flap
51V, 52H, 53S, 54A, 58R, 59N, 60Q, 61T
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

283D

putative NTP binding site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 339D
CDD
cd01647 (RT_LTR)

284L

putative NTP binding site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 339D
CDD
cd01647 (RT_LTR)

285Q

putative NTP binding site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 339D
CDD
cd01647 (RT_LTR)

286S

putative NTP binding site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 339D
CDD
cd01647 (RT_LTR)

287V

putative NTP binding site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 339D
CDD
cd01647 (RT_LTR)

288Y

putative NTP binding site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 339D
CDD
cd01647 (RT_LTR)

309F

putative NTP binding site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 339D
CDD
cd01647 (RT_LTR)

339D

putative NTP binding site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 339D
CDD
cd01647 (RT_LTR)
putative active si...

283D

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

284L

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

285Q

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

286S

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

287V

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

288Y

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

309F

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

310V

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

337Y

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

339D

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)

340D

putative active site
283D, 284L, 285Q, 286S, 287V, 288Y, 309F, 310V, 337Y, 339D, 340D
CDD
cd01647 (RT_LTR)
putative nucleic a...

310V

putative nucleic acid binding site
310V
CDD
cd01647 (RT_LTR)

Protein sequence

>MCA_03509_1
MSKLIAKLSFLSKFVTLSQLDSGASSNFISQLLFQKLKLRKFAKTIKPKDVHSAFKERNQTRFIINLTYRIGNKPFSSTF
FVINKLSKNVILGIPFIKEFSKYINWNQSTVAGVKSLKTNNIFTNAVQFCRDGKRNSPEECFFIKPDKPDTTYSNLPSDL
KDYKEALITDSLSEFSPKRNAEHRIDIISDNKPTVRPYYRPSLEENNILVEEISKLLKISSNRFFHFAIPTLVLFAKKKD
AFYRMCIDYRGFNFINVKNRYPLPKTEHLLNNLKKAKHFSKLDLQSVYHQEKTGFSTKNGHSKVLVTPFVSINAPTAFLH
FMNDIFRTFLEDFVNVYLDDIFIFPLIFYHCPFNPKLKLTTVTQNRNKLKPYTSNINTLSFVVISISNPTLMFVLESLPL
DQKRMSESWSILFLRRGNVVRIRVDNMPLIYSSQ

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_03509_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component