Protein

MCA_03451_1

Length
746 amino acids

Gene name: RAD30

Description: DNA polymerase eta

Browser: contigC:8920-11221-

RNA-seq: read pairs 474, FPKM 7.8, percentile rank 22.0% (100% = highest expression)

Protein function

Annotation:RAD30DNA polymerase eta
KEGG:K03509POLH DNA polymerase eta [EC:2.7.7.7]
EGGNOG:0PFN6RAD30Sister chromatid cohesion protein
SGD closest match:S000002827RAD30DNA polymerase eta
CGD closest match:CAL0000186115RAD32DNA-directed DNA polymerase eta

Protein alignments

%idAln lengthE-value
MIA_05195_144.10%8050.0MIA_05195_1
A0A0J9XGL8_GEOCN34.70%7781e-133Similar to Saccharomyces cerevisiae YDR419W RAD30 DNA polymerase eta OS=Geotrichum candidum GN=BN980_GECA16s01550g PE=4 SV=1
UniRef50_A0A0J9XGL834.70%7783e-130Similar to Saccharomyces cerevisiae YDR419W RAD30 DNA polymerase eta n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGL8_GEOCN
A0A1E3PDE0_9ASCO34.83%8014e-122DNA/RNA polymerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53658 PE=4 SV=1
A0A167E0C2_9ASCO33.38%7522e-114Rad30p OS=Sugiyamaella lignohabitans GN=RAD30 PE=4 SV=1
A0A060T3C6_BLAAD37.36%5221e-105ARAD1C31834p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C31834g PE=4 SV=1
A0A1D8PGZ5_CANAL40.37%4933e-101DNA-directed DNA polymerase eta OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAD32 PE=4 SV=1
Q6CDC9_YARLI31.90%6743e-101YALI0C01573p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C01573g PE=4 SV=1
A0A1E4TG47_9ASCO41.22%4103e-84Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19410 PE=4 SV=1
POLH_YEAST34.88%6051e-76DNA polymerase eta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD30 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2743

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 746

Detailed signature matches

  1. Family IPR017061
    DNA polymerase eta/kappa/iota/IV
    1. PIRSF036603 (DNA_po...)
  2. Domain IPR001126
    UmuC domain
    1. PF00817 (IMS)
    2. PS50173 (UMUC)
  3. Domain IPR017961
    DNA polymerase, Y-family, little finger domain
    1. SSF100879 (Lesion b...)
    2. G3DSA:3.30.14...
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.15...
  2. G3DSA:3.30.70...
  3. SSF56672 (DNA/RNA p...)
  4. mobidb-lite (disord...)

Protein sequence

>MCA_03451_1
MSITTSSRYTGKDISLLSDQSKSYSSPLSVICHIDLDAFYAQCEQIRLGLKKNDPVVCQQWQSVIAVSYGARKYGIKRND
TVKIVREKCPNAILAHVATFQKGQVDWKYHATPNMAYHKVSLDPYRRESRKIFRLIKQFFTSNFPDTPLVSIEKASVDET
YIDLGPIVFQNLIKMFPVLNSLGPEDHLPSVPNLKDLLPEMKWNGIVIGSANHELQGEAVGYDLYNMDKSQSKNNSMKLD
APLEPKDWDDVALLIGSQIIYKLRKEIFQNLGYTCSAGISRVRSLSKLASGKFKPALQTIVRSSQIPYFLEDFELTDIGG
LGGKLGDHIKTSLKLPTENSIKYIRESLTLEEMQKHISPQLAKKLKRLVEGSEHAPVNIRTDVKSMASVKHFTNFPLKTH
KDVLEWLRVFSAELSNRVIELSDDEQSSKRLSFYPKAISVSFKNHADHVARQKQISFPLGVSRDNLRNEMFELSQSILKQ
METHEIKKNRVLYPCEMISLDINGFINLETYYHDAETKSISSFFKPMSVRGIKEDDKKSIKETQHDEETIDFCKQELGSN
NQDASTKINNFTEAQSSQKPTSLILDKKSLIPEREHKGLDTNPSRDDYNSDEDDNINVDWGMLEDLFVTGSNDTNGSVVT
SVQCPRCHRDLKLTDIQEHKDWHFARDIHRAQKKGNTSLSTFFKSETTFKLAPLSESSTKNDSGKLELTRVPPKLNKTAS
KNPSNGQMSRSNKRAKIDKNQTFLKF

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003684 damaged DNA binding

Cellular Component

None predicted.