Protein

MCA_03443_1

Length
570 amino acids

Gene name: MSM1

Description: Methionine--tRNA ligase, mitochondrial

Browser: contigB:4435684-4437397-

RNA-seq: read pairs 1367, FPKM 29.6, percentile rank 52.4% (100% = highest expression)

Protein function

Annotation:MSM1Methionine--tRNA ligase, mitochondrial
KEGG:K01874MARS methionyl-tRNA synthetase [EC:6.1.1.10]
EGGNOG:0PG4YMSM1methionyl-tRNA synthetase
SGD closest match:S000003403MSM1Methionine--tRNA ligase, mitochondrial
CGD closest match:CAL0000183257MSM1Methionine--tRNA ligase

Protein alignments

%idAln lengthE-value
MIA_05630_169.11%5310.0MIA_05630_1
A0A0J9X9H3_GEOCN57.75%5610.0Similar to Saccharomyces cerevisiae YGR171C MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS) OS=Geotrichum candidum GN=BN980_GECA06s00373g PE=3 SV=1
UniRef50_A0A0J9X9H357.75%5610.0Similar to Saccharomyces cerevisiae YGR171C MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS) n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X9H3_GEOCN
A0A167DB42_9ASCO55.19%5200.0Methionine--tRNA ligase MSM1 OS=Sugiyamaella lignohabitans GN=MSM1 PE=3 SV=1
A0A060T7J9_BLAAD51.43%5580.0ARAD1B24376p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B24376g PE=3 SV=1
A0A1E3PPB8_9ASCO50.67%5212e-180Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82440 PE=3 SV=1
Q6CAE1_YARLI47.65%5333e-166YALI0D03619p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D03619g PE=3 SV=1
A0A1E4TJP3_9ASCO44.80%5382e-156Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30190 PE=3 SV=1
A0A1D8PP08_CANAL43.84%5682e-153Methionine--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MSM1 PE=3 SV=1
SYMM_YEAST41.90%5683e-139Methionine--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSM1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8637
Predicted cleavage: 40

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 570

Detailed signature matches

  1. Family IPR014758
    Methionyl-tRNA synthetase
    1. TIGR00398
  2. Domain IPR014729
    Rossmann-like alpha/beta/alpha sandwich fold
    1. G3DSA:3.40.50...
  3. Domain IPR015413
    Methionyl/Leucyl tRNA synthetase
    1. PF09334 (tRNA-synt_1g)
  4. Domain IPR033911
    Methioninyl-tRNA synthetase core domain
    1. PR01041 (TRNASYNTHMET)
    2. cd00814 (MetRS_core)
  5. Domain IPR009080
    Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    1. G3DSA:1.10.73...
    2. SSF47323 (Anticodon...)
  6. Domain IPR013155
    Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
    1. PF08264 (Anticodon_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF52374 (Nucleotid...)
  2. cd07957 (Anticodon_...)

Residue annotation

  1. active site cd00814
  2. HIGH motif cd00814
  3. KMSKS motif cd00814
  4. tRNA binding surfa...
  5. anticodon binding ...

Protein sequence

>MCA_03443_1
MFPLARNAQKLRLSFNLSNLQGGSVAEFKRSFVSSQRLFKSLDSNQTKPYYVTTPIFYVNASPHIGHLHSMVLADTLKNW
ASFISPNISGSFLTTGTDEHGLKVQQAADAAGKPPKPFVDQASEIFKQLAEAGEISYDRFIRTTDDDHIRASKEIWKILE
QNGYIYKGQHSGWYSISDETFYPENQVEKKKVIEKGPNGEDVEREISVSVETGKIVEWTSEENYFFSLSKIQPKLLEFLK
KNPEFIYPKARYQQILNEVESGLPDLSISRPKSRCSWGIPVPGAEDSQVMYVWLDALTNYLTSAGFPWNGDNQSIWPADV
HVIGKDIIRFHAIYWPAFLLAADIVPPKHIVVHSHWIMKGSKMSKSLGNVVDPFSTIKTFGVDSLKFFLMNDSFLNRDSE
YSNDRIILRHNTELVNKYGNLVARICGKNFNISRALATDIEERSKLAADISEVVEKVKSNMNVFNISGALHEIQELVSNA
NSYMQDSEPWKLKNDLKKQDSIIRDVSEAARVASIMLTPFIPKLSHAMLDRLAVNKANRGIEYAKYLEDKSYGMDANRKG
DYPIKPILID

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm