Protein

MCA_03408_1

Length
287 amino acids

Gene name: PRO3

Description: Pyrroline-5-carboxylate reductase

Browser: contigB:4359969-4360833+

RNA-seq: read pairs 3894, FPKM 167.1, percentile rank 86.1% (100% = highest expression)

Protein function

Annotation:PRO3Pyrroline-5-carboxylate reductase
KEGG:K00286proC pyrroline-5-carboxylate reductase [EC:1.5.1.2]
EGGNOG:0PFDIPRO3pyrroline-5-carboxylate reductase
SGD closest match:S000000825PRO3Pyrroline-5-carboxylate reductase
CGD closest match:CAL0000177527PRO3Pyrroline-5-carboxylate reductase

Protein alignments

%idAln lengthE-value
MIA_05639_178.80%2831e-162MIA_05639_1
A0A0J9X9I0_GEOCN74.20%2832e-148Pyrroline-5-carboxylate reductase OS=Geotrichum candidum GN=BN980_GECA05s02012g PE=3 SV=1
A0A1E3PKE3_9ASCO63.07%2871e-129Pyrroline-5-carboxylate reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51164 PE=3 SV=1
A0A060T6H3_BLAAD58.80%2843e-115Pyrroline-5-carboxylate reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B12188g PE=3 SV=1
A0A167D4Z1_9ASCO59.66%2901e-114Pyrroline-5-carboxylate reductase OS=Sugiyamaella lignohabitans GN=PRO3 PE=3 SV=1
UniRef50_A0A167D4Z159.66%2903e-111Pyrroline-5-carboxylate reductase n=6 Tax=Saccharomycetales TaxID=4892 RepID=A0A167D4Z1_9ASCO
Q6CEN0_YARLI54.51%2888e-101Pyrroline-5-carboxylate reductase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B14399g PE=3 SV=1
A0A1D8PKZ7_CANAL42.81%2852e-70Pyrroline-5-carboxylate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRO3 PE=3 SV=1
P5CR_YEAST41.38%2905e-63Pyrroline-5-carboxylate reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRO3 PE=1 SV=1
A0A1E4T9U3_9ASCO35.23%2818e-42Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_124336 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0508

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 287

Detailed signature matches

  1. Family IPR000304
    Pyrroline-5-carboxylate reductase
    1. PIRSF000193 (P5CR)
    2. PS00521 (P5CR)
    3. TIGR00112
    4. MF_01925 (P5C_reduc...)
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR028939
    Pyrroline-5-carboxylate reductase, catalytic, N-terminal
    1. PF03807 (F420_oxidored)
  4. Domain IPR008927
    6-phosphogluconate dehydrogenase C-terminal domain-like
    1. SSF48179 (6-phospho...)
  5. Domain IPR029036
    Pyrroline-5-carboxylate reductase, dimerisation domain
    1. PF14748 (P5CR_dimer)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.37...
  2. G3DSA:3.40.50...

Protein sequence

>MCA_03408_1
MTDLKNNYTLGVIASGTMGTAVLNAIIQGVSSGSSDTAPLPSTFYATVNSQASVERLGKQFGEKVSVSIGENNKVVEASD
LIILGCKPFMAEKILSAIPSELFKNKIVISLLAGKTIQQLTDLTGGNALVVRAMTNTPSKLGAGMTVVSYPGSTDVSESV
KSAITWIFNQTGRSLVMDEKYMDVATALCGSGPAFCFLMIEALSDGAVKMGMPYPIAQECAAQVLHGAAQMVLEGNHPAV
LRNAVCTPGGTTIGGLSILEEGSVRSSVAKAVVEATNIATHLSKPSK

GO term prediction

Biological Process

GO:0006561 proline biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004735 pyrroline-5-carboxylate reductase activity

Cellular Component

None predicted.