Protein

MCA_03406_1

Length
660 amino acids

Browser: contigB:4354596-4356579+

RNA-seq: read pairs 1179, FPKM 22.0, percentile rank 44.0% (100% = highest expression)

Protein function

KEGG:K00297metF methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]
EGGNOG:0PH5RPGUG_01501Methylenetetrahydrofolate reductase
SGD closest match:S000005944MET12Methylenetetrahydrofolate reductase 1
CGD closest match:CAL0000201618orf19.5321Methylenetetrahydrofolate reductase

Protein alignments

%idAln lengthE-value
MIA_05637_158.46%6500.0MIA_05637_1
A0A0J9X8D8_GEOCN57.10%6690.0Methylenetetrahydrofolate reductase OS=Geotrichum candidum GN=BN980_GECA05s02023g PE=3 SV=1
A0A1E3PKC7_9ASCO54.55%6600.0Methylenetetrahydrofolate reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46482 PE=3 SV=1
Q6CEM7_YARLI52.59%6560.0Methylenetetrahydrofolate reductase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B14465g PE=3 SV=1
UniRef50_Q6CEM752.59%6560.0Methylenetetrahydrofolate reductase n=6 Tax=Saccharomycetales TaxID=4892 RepID=Q6CEM7_YARLI
A0A060TB28_BLAAD52.28%6580.0Methylenetetrahydrofolate reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B12232g PE=3 SV=1
A0A167D496_9ASCO55.05%6540.0Methylenetetrahydrofolate reductase OS=Sugiyamaella lignohabitans GN=MET12 PE=3 SV=1
Q5A5S8_CANAL49.62%6650.0Methylenetetrahydrofolate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5321 PE=3 SV=1
MTHR1_YEAST47.80%6590.0Methylenetetrahydrofolate reductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET12 PE=1 SV=2
A0A1E4TKA7_9ASCO47.71%6540.0Methylenetetrahydrofolate reductase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30430 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1882

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 660

Detailed signature matches

  1. Family IPR003171
    Methylenetetrahydrofolate reductase
    1. cd00537 (MTHFR)
    2. PF02219 (MTHFR)
  2. Family IPR004621
    Eukaryotic-type methylenetetrahydrofolate reductase
    1. TIGR00677
  3. Domain IPR029041
    FAD-linked oxidoreductase-like
    1. SSF51730 (FAD-linke...)
    2. G3DSA:3.20.20...
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Residue annotation

  1. FAD binding site c...

Protein sequence

>MCA_03406_1
MTSKSQKISDLINSLDGSTPFYSFEFFPPKTKQGGENLRARIERMAKLNPLFVTVTWGAGGSTASKSLELAGFIQQQGIN
TCLHLTCTNMDKELIDKALEKCKSLGIRNILALRGDPPRGEEYQQPNSSDKFAHAVDLVKYIRQNHGDYFCIGVAAYPEG
HVDGSDISNQNPENDLPYLVEKVQAGADFIITQLFYDTEKFLKFEEMLLNHPSKLFENIPIIPGLMPISTYQSFARASRL
SHASIPQELLESVEKVNNNDDLVKAFGVKVLCKIMETVHSKSDKRIRGFHFYTLNLERSVALIIENSSILNSNIPSSSPL
DSTEESAVQEETDGTSLPSGPEPGQRRRRRSSLTMHNRVLVEQQKPTKESQLSVTYKEMAEAVVKPVSSRDILAISSGEG
SLGREVNWDDFPNGRFGDSRSPAYGVIDGYGPTLHVDAGKIFTFWGYPKTKADITNLIIEHLTGELGALPWSDDALNPET
GLIQEELIAMNKRGMWTVASQPACEGVYSGDKIFGWGPKGGFVFQKPFVEFFISPEDWEQLKQKLDKHISSRDSKASVSS
YYACNHTLKLETNLPRNSSSAVTWGVFPNKEILQSTIIEEESFLVWAEEAFALWKEWKYAYSPNSETYKLLSDIHDSYYL
VTLVYHDFKNPEGLWNLILN

GO term prediction

Biological Process

GO:0006555 methionine metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity

Cellular Component

None predicted.