Protein

MCA_03402_1

Length
1,024 amino acids

Gene name: PRP5

Description: Pre-mRNA-processing ATP-dependent RNA helicase PRP5

Browser: contigB:4344315-4347505+

RNA-seq: read pairs 2587, FPKM 31.2, percentile rank 53.7% (100% = highest expression)

Protein function

Annotation:PRP5Pre-mRNA-processing ATP-dependent RNA helicase PRP5
KEGG:K12811DDX46 ATP-dependent RNA helicase DDX46/PRP5 [EC:3.6.4.13]
EGGNOG:0PHNKPRP5ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity)
SGD closest match:S000000441PRP5Pre-mRNA-processing ATP-dependent RNA helicase PRP5
CGD closest match:CAL0000188191PRP5Pre-mRNA-processing ATP-dependent RNA helicase PRP5

Protein alignments

%idAln lengthE-value
MIA_00185_165.94%8660.0MIA_00185_1
A0A0J9X9Y7_GEOCN62.56%8920.0Similar to Saccharomyces cerevisiae YBR237W PRP5 RNA helicase in the DEAD-box family, necessary for prespliceosome formation OS=Geotrichum candidum GN=BN980_GECA06s04410g PE=4 SV=1
A0A060T7N3_BLAAD65.07%6870.0ARAD1C23320p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C23320g PE=4 SV=1
A0A161HJV5_9ASCO53.85%8950.0DEAD-box RNA helicase PRP5 OS=Sugiyamaella lignohabitans GN=PRP5 PE=4 SV=1
UniRef50_A0A161HJV553.85%8950.0DEAD-box RNA helicase PRP5 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A161HJV5_9ASCO
A0A1E3PTK8_9ASCO54.20%7270.0p-loop containing nucleoside triphosphate hydrolase protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49309 PE=4 SV=1
A0A1E4TKL3_9ASCO52.78%6840.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_21242 PE=3 SV=1
PRP5_YARLI50.46%7570.0Pre-mRNA-processing ATP-dependent RNA helicase PRP5 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PRP5 PE=3 SV=1
PRP5_CANAL47.79%6789e-174Pre-mRNA-processing ATP-dependent RNA helicase PRP5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRP5 PE=3 SV=1
PRP5_YEAST37.65%7412e-125Pre-mRNA-processing ATP-dependent RNA helicase PRP5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP5 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1418

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 900 1024

Detailed signature matches

  1. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  2. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  3. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  4. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. SITE IPR000629
    ATP-dependent RNA helicase DEAD-box, conserved site
    1. PS00039 (DEAD_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd00079 (HELICc)
  3. cd00268 (DEADc)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg++ binding site ...
  3. motif III cd00268
  4. nucleotide binding...
  5. ATP-binding site c...

Protein sequence

>MCA_03402_1
MSRSRSPHRDPYYYSSSRDNRDDHSSRHSYQSGRSHSRYRENRNQDYSYKSRYRDHETNRSRERYSDSSYRDNRRSDNEP
SRIDKSTSDSLESKSYKEQSIQTSDSSVSKSSSIGIALASTSNTNLNISTSSKTSLNTNPQHETTTQPVLKDNKSQRTTA
ESQNSNSNKSITDEEKKRIRMERLAQWKLKKAQEKSKNANESEKVSSKFVPNQQTAISSDESSLKPKSIFEQSLKKSDSS
SQKLNPLALFNRNVLSKNNPINKFSFQNIDSSSSNALPKSKKPLFFEKSDEEYNSKKHQVEEEDDDDDPLDAYMNSIQVE
QSKETEKQTVLLPDIMEVEGSGDDDNGTELDGEFDTVNPELLLAQLEKKKRKDIPVVDHSTIDYEPFRKQFYFEPPELSQ
LSPEDLDMLRLELDGIKVRGQKCPAPVTKWSRFGLPVNVMDIINNLGFEKPTSIQAQAIPAIMAGRDVIGIAKTGSGKTM
AFLLPLFRHIKDQRPLAKLEGPMALVMTPTRELAVQIYHECTPFLKALNLRAVCAYGGSPIKEQIADLKRGAEIIVCTPG
RMIDLLAANSGRVTNLQRVTYLVLDEADRMFDLGFEPQIMKIIQNIRPDRQTVLFSATFPRQMALLARKILTKAVEIIVG
ARSIVAPEIKQIIEVREDKTKFNRLLEVLGDFFNENPPDSRALIFVDRQDSADILLKELFARGYPSLSIHGGKEQIDRDS
ALSDFRNGVINILIATSVAARGLDVKQLKLVINYDAPNHMEDYVHRVGRTGRAGNTGTAITFITPEDGKAAAFISKALKL
SNVPVPDEVEKMAETFLKKVKSGEAAFGSGFGGKGLEKLDQARDSARKLERKAYGEDDGDDDSKDTEESTNSLLPVLDPS
SNANPLFKINPAVITPGRHSSSKEKTSVLRMGAAPDNHGPDTSAFHATLEINDFPQQARWAVTNNSNVTKIIEANSTSIT
TKGRFYPPGKQPGEGEEPKLYILIEGQSEISVANAHKALVELLTSGISQAIASESHRTGRYTVA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.