Protein
MCA_03365_1
Length
345 amino acids
Gene name: XYL2
Description: L-iditol 2-dehydrogenase
Browser: contigB:4193166-4194343-
RNA-seq: read pairs 31744, FPKM 1133.6, percentile rank 96.8% (100% = highest expression)
Protein function
| Annotation: | XYL2 | L-iditol 2-dehydrogenase | |
|---|---|---|---|
| KEGG: | K05351 | E1.1.1.9 | D-xylulose reductase [EC:1.1.1.9] |
| EGGNOG: | 0PFUH | XYL2 | Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5- phosphate, which enters pentose phosphate pathway |
| SGD closest match: | S000003920 | SOR1 | Sorbitol dehydrogenase 1 |
| CGD closest match: | CAL0000192665 | XYL2 | L-iditol 2-dehydrogenase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01616_1 | 84.80% | 342 | 0.0 | MIA_01616_1 |
| A0A0J9XF09_GEOCN | 81.82% | 341 | 0.0 | Similar to Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase OS=Geotrichum candidum GN=BN980_GECA13s00901g PE=3 SV=1 |
| A0A167EEZ6_9ASCO | 68.73% | 339 | 4e-172 | L-iditol 2-dehydrogenase SOR1 OS=Sugiyamaella lignohabitans GN=SOR1 PE=3 SV=1 |
| A0A1E3PH44_9ASCO | 65.12% | 344 | 1e-165 | GroES-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47208 PE=3 SV=1 |
| Q6C648_YARLI | 64.83% | 344 | 7e-164 | YALI0E12463p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E12463g PE=3 SV=1 |
| UniRef50_A1CFY8 | 59.06% | 342 | 7e-140 | Probable D-xylulose reductase A n=160 Tax=Dikarya TaxID=451864 RepID=XYL2_ASPCL |
| DHSO1_YEAST | 58.48% | 342 | 9e-138 | Sorbitol dehydrogenase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SOR1 PE=3 SV=1 |
| Q6KAV2_BLAAD | 58.53% | 340 | 4e-133 | ARAD1D37840p OS=Blastobotrys adeninivorans GN=axdh1 PE=3 SV=1 |
| A0A1E4TKX5_9ASCO | 53.85% | 338 | 9e-122 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_86620 PE=3 SV=1 |
| A0A1D8PUB4_CANAL | 53.37% | 356 | 2e-116 | L-iditol 2-dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=XYL2 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0098
Protein family membership
None predicted.
Domains and repeats
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Domain
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Domain
-
Domain
1
50
100
150
200
250
300
345
Detailed signature matches
no IPR
Unintegrated signatures
-
-
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cd05285 (sorbitol_DH)
Residue annotation
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catalytic Zn bindi...
-
inhibitor binding ...
-
structural Zn bind...
-
NADP binding site ...
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tetramer interface...
Protein sequence
>MCA_03365_1 MPVFNDVSYVDKPVPEIKDPHYVKIKVRKTGICGSDIHYYTHGSIGHFVVKEPMVLGHESAGEIVEVGDAVKTLKVGDKV AMEPGIPSRYSDEYKAGKYNLCPCMAFAATPPYDGTLCRYYLLPEDFCVKLPDNVSLEEGAMAEPLSVGVHISKLAKIAP GDVVVVFGAGPVGLLAASCAMAFGSTKVVSVDLVQSKLDLAKEIGIPYTFVPEKGDSAQESAEKIRKLLGGIKPDVAIDA SGAEASINTAIYVLKEGGTFVQAGMGKDEINFPIAEFCSKELLARGCFRYGYGDYKLAVEFIASGKVPVKKLITHRFKFT EAEEAFKTVRDGKAVKVIIDGPEDE
GO term prediction
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
Cellular Component
None predicted.