Protein

MCA_03365_1

Length
345 amino acids


Gene name: XYL2

Description: L-iditol 2-dehydrogenase

Browser: contigB:4193166-4194343-

RNA-seq: read pairs 31744, FPKM 1133.6, percentile rank 96.8% (100% = highest expression)

Protein function

Annotation:XYL2L-iditol 2-dehydrogenase
KEGG:K05351E1.1.1.9 D-xylulose reductase [EC:1.1.1.9]
EGGNOG:0PFUHXYL2Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5- phosphate, which enters pentose phosphate pathway
SGD closest match:S000003920SOR1Sorbitol dehydrogenase 1
CGD closest match:CAL0000192665XYL2L-iditol 2-dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_01616_184.80%3420.0MIA_01616_1
A0A0J9XF09_GEOCN81.82%3410.0Similar to Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase OS=Geotrichum candidum GN=BN980_GECA13s00901g PE=3 SV=1
A0A167EEZ6_9ASCO68.73%3394e-172L-iditol 2-dehydrogenase SOR1 OS=Sugiyamaella lignohabitans GN=SOR1 PE=3 SV=1
A0A1E3PH44_9ASCO65.12%3441e-165GroES-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47208 PE=3 SV=1
Q6C648_YARLI64.83%3447e-164YALI0E12463p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E12463g PE=3 SV=1
UniRef50_A1CFY859.06%3427e-140Probable D-xylulose reductase A n=160 Tax=Dikarya TaxID=451864 RepID=XYL2_ASPCL
DHSO1_YEAST58.48%3429e-138Sorbitol dehydrogenase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SOR1 PE=3 SV=1
Q6KAV2_BLAAD58.53%3404e-133ARAD1D37840p OS=Blastobotrys adeninivorans GN=axdh1 PE=3 SV=1
A0A1E4TKX5_9ASCO53.85%3389e-122Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_86620 PE=3 SV=1
A0A1D8PUB4_CANAL53.37%3562e-116L-iditol 2-dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=XYL2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0098

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 345

Detailed signature matches

    1. SM00829 (PKS_ER_nam...)
    1. SSF50129 (GroES-like)
    1. PF08240 (ADH_N)
    1. SSF51735 (NAD(P)-bi...)
    1. PF00107 (ADH_zinc_N)
    1. PS00059 (ADH_ZINC)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd05285 (sorbitol_DH)

Residue annotation

  1. catalytic Zn bindi...
  2. inhibitor binding ...
  3. structural Zn bind...
  4. NADP binding site ...
  5. tetramer interface...

Protein sequence

>MCA_03365_1
MPVFNDVSYVDKPVPEIKDPHYVKIKVRKTGICGSDIHYYTHGSIGHFVVKEPMVLGHESAGEIVEVGDAVKTLKVGDKV
AMEPGIPSRYSDEYKAGKYNLCPCMAFAATPPYDGTLCRYYLLPEDFCVKLPDNVSLEEGAMAEPLSVGVHISKLAKIAP
GDVVVVFGAGPVGLLAASCAMAFGSTKVVSVDLVQSKLDLAKEIGIPYTFVPEKGDSAQESAEKIRKLLGGIKPDVAIDA
SGAEASINTAIYVLKEGGTFVQAGMGKDEINFPIAEFCSKELLARGCFRYGYGDYKLAVEFIASGKVPVKKLITHRFKFT
EAEEAFKTVRDGKAVKVIIDGPEDE

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.