Protein

MCA_02995_1

Length
496 amino acids

Gene name: FRS2

Description: Phenylalanine--tRNA ligase alpha subunit

Browser: contigB:3029672-3031163+

RNA-seq: read pairs 7286, FPKM 181.1, percentile rank 86.9% (100% = highest expression)

Protein function

Annotation:FRS2Phenylalanine--tRNA ligase alpha subunit
KEGG:K01889FARSA phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
EGGNOG:0PG09FRS2Phenylalanyl-tRNA synthetase
SGD closest match:S000001872FRS2Phenylalanine--tRNA ligase alpha subunit
CGD closest match:CAL0000201701FRS2Phenylalanine--tRNA ligase subunit alpha

Protein alignments

%idAln lengthE-value
MIA_02642_183.67%4960.0MIA_02642_1
A0A0J9XKV7_GEOCN80.85%4960.0Similar to Saccharomyces cerevisiae YFL022C FRS2 Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase OS=Geotrichum candidum GN=BN980_GECA26s00087g PE=4 SV=1
A0A167DPQ1_9ASCO73.79%4960.0Phenylalanine--tRNA ligase subunit alpha OS=Sugiyamaella lignohabitans GN=FRS2 PE=4 SV=1
A0A060TAP9_BLAAD72.38%4960.0ARAD1D25498p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D25498g PE=4 SV=1
A0A1E3PDT9_9ASCO72.29%4980.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84229 PE=4 SV=1
Q6C8V7_YARLI71.52%4950.0YALI0D16643p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D16643g PE=4 SV=1
UniRef50_A0A099P8X869.22%4970.0Uncharacterized protein n=14 Tax=Opisthokonta TaxID=33154 RepID=A0A099P8X8_PICKU
A0A1E4T9R5_9ASCO69.03%4940.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_33061 PE=4 SV=1
A0A1D8PCT4_CANAL66.47%4980.0Phenylalanine--tRNA ligase subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FRS2 PE=4 SV=1
SYFA_YEAST63.29%5040.0Phenylalanine--tRNA ligase alpha subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRS2 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2905

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 496

Detailed signature matches

  1. Family IPR004529
    Phenylalanyl-tRNA synthetase, class IIc, alpha subunit
    1. TIGR00468
  2. Domain IPR002319
    Phenylalanyl-tRNA synthetase
    1. PF01409 (tRNA-synt_2d)
  3. Domain IPR006195
    Aminoacyl-tRNA synthetase, class II
    1. PS50862 (AA_TRNA_LI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.93...
  2. SSF55681 (Class II ...)
  3. cd00496 (PheRS_alph...)

Residue annotation

  1. dimer interface cd...
  2. motif 1 cd00496
  3. active site cd00496
  4. motif 2 cd00496
  5. motif 3 cd00496

Protein sequence

>MCA_02995_1
MSDFAITILKTLDQAPDGKIPDSRVAFPNVSTEQIQAAVTSLAAKSMVTFESKDQELWTLTKEAEDIVANGSHEFRLFEE
VIKSMEGLKLADVSKVLGPSGKLGQQRAFKNGWVKKEGDTLVRGVESTPEDTTAIELKTIKETGTLENNAKELADLKKRK
LITKTKLISFSIAKGPEFALEIKKLETDLTIDMVQNGSWKNAEFKPYNFQAEGVPPLAGALHPLMKVREEFRQIFFSMGF
TEMPTAKYVETGFWNFDALYVPQQHPARDLQDTFYLKDPSLADLPDDKEYLKNVQHAHEGGAYDSIGYRYPWKLDETRKL
VLRTHTTAVSANMLHKLAQDPKPSRFFSIDRVFRNEAVDATHLAEFHQVEGVIADYNLTLGDLIGFMERFFAKMGVHDLR
FKATYNPYTEPSMEIYSWHQGLKKWVEIGNSGMFRPEMLEAMGLPKDMRVHGWGLSLERPTMIKYGVSNIRELLGHKVSL
DFIEHNPAVRLDEDLV

GO term prediction

Biological Process

GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation

Molecular Function

GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm