MCA_02976_1

Protein

Length

448 amino acids

Gene name: TUB1

Description: Tubulin alpha-1 chain

Browser: contigB:2986699-2988579-

RNA-seq: read pairs 30134, FPKM 829.3, percentile rank 96.1% (100% = highest expression)

Protein function

Annotation:		TUB1	Tubulin alpha-1 chain
KEGG:	K07374	TUBA	tubulin alpha
EGGNOG:	0PFTH	TUB1	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain
SGD closest match:	S000004550	TUB1	Tubulin alpha-1 chain

Protein alignments

	%id	Aln length
A0A060TF27_BLAAD	93.71%	445	Tubulin alpha chain OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D19580g PE=3 SV=1
A0A167CUH9_9ASCO	92.87%	449	Tubulin alpha chain OS=Sugiyamaella lignohabitans GN=TUB1 PE=3 SV=1
A0A1E3PMH4_9ASCO	92.90%	451	Tubulin alpha chain OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82902 PE=3 SV=1
A0A0J9XEI9_GEOCN	90.34%	445	Tubulin alpha chain OS=Geotrichum candidum GN=BN980_GECA13s00571g PE=3 SV=1
Q6C5C0_YARLI	90.22%	450	Tubulin alpha chain OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E19360g PE=3 SV=1
MIA_02447_1	88.39%	448	MIA_02447_1
A0A1E4TDZ1_9ASCO	84.38%	448	Tubulin alpha chain OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_43583 PE=3 SV=1
A0A1D8PTV4_CANAL	80.89%	450	Tubulin alpha chain OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TUB1 PE=3 SV=1
UniRef50_P04689	81.45%	442	Tubulin alpha-2 chain n=397 Tax=Eukaryota TaxID=2759 RepID=TBA2_SCHPO
TBA1_YEAST	80.00%	450	Tubulin alpha-1 chain OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TUB1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0640

Protein family membership

Tubulin (IPR000217)
- Alpha tubulin (IPR002452)

Domains and repeats

Domain
1 - 266
Tubulin/FtsZ, GTPase domain (IPR003008)
Domain
247 - 437
Tubulin/FtsZ, C-terminal (IPR008280)
Domain
249 - 394
Tubulin/FtsZ, 2-layer sandwich domain (IPR018316)

1 50 100 150 200 250 300 350 400 448

Detailed signature matches

IPR000217

Tubulin
1. PR01161 (TUBULIN)
  
  54 - 73
  
  PRINTS
  PR01161 (TUBULIN)
  
  135 - 153
  
  PRINTS
  PR01161 (TUBULIN)
  
  96 - 107
  
  PRINTS
  PR01161 (TUBULIN)
  
  179 - 192
  
  PRINTS
  PR01161 (TUBULIN)
  
  109 - 133
  
  PRINTS
  PR01161 (TUBULIN)
  
  10 - 30
  
  PRINTS
  PR01161 (TUBULIN)
  
  193 - 213
  
  PRINTS
  PR01161 (TUBULIN)
  
  381 - 409
  
  PRINTS
  PR01161 (TUBULIN)
  
  154 - 175
  
  PRINTS
  PR01161 (TUBULIN)
IPR002452

Alpha tubulin
1. PR01162 (ALPHATUBULIN)
  
  348 - 361
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  215 - 227
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  18 - 33
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  46 - 59
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  121 - 129
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  322 - 343
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  386 - 402
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  361 - 380
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  423 - 439
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  89 - 102
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  275 - 290
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  162 - 173
  
  PRINTS
  PR01162 (ALPHATUBULIN)
  
  149 - 161
  
  PRINTS
  PR01162 (ALPHATUBULIN)
IPR003008

Tubulin/FtsZ, GTPase domain
1. PF00091 (Tubulin)
  
  3 - 214
  
  Pfam
  PF00091 (Tubulin)
2. SM00864 (Tubulin_4)
  
  50 - 247
  
  SMART
  SM00864 (Tubulin_4)
3. G3DSA:3.40.50...
  
  1 - 266
  
  GENE3D
  G3DSA:3.40.50.1440 (G3DSA:3.40.50.1440)
4. SSF52490 (Tubulin n...)
  
  1 - 245
  
  SUPERFAMILY
  SSF52490 (Tubulin nucleotide-binding domain-like)
IPR008280

Tubulin/FtsZ, C-terminal
1. SSF55307 (Tubulin C...)
  
  247 - 437
  
  SUPERFAMILY
  SSF55307 (Tubulin C-terminal domain-like)
IPR018316

Tubulin/FtsZ, 2-layer sandwich domain
1. PF03953 (Tubulin_C)
  
  264 - 392
  
  Pfam
  PF03953 (Tubulin_C)
2. SM00865 (Tubulin_C_4)
  
  249 - 394
  
  SMART
  SM00865 (Tubulin_C_4)
3. G3DSA:3.30.13...
  
  267 - 384
  
  GENE3D
  G3DSA:3.30.1330.20 (G3DSA:3.30.1330.20)
IPR017975

Tubulin, conserved site
1. PS00227 (TUBULIN)
  
  143 - 149
  
  PROSITE patterns
  PS00227 (TUBULIN)

no IPR

Unintegrated signatures

Coil

419 - 439

COILS
Coil (Coil)
G3DSA:1.10.28...

385 - 436

GENE3D
G3DSA:1.10.287.600 (G3DSA:1.10.287.600)
cd02186 (alpha_tubulin)

2 - 436

CDD
cd02186 (alpha_tubulin)

Residue annotation

beta/alpha domain ...

2R

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

200D

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

254N

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

255E

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

257Q

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

258T

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

259N

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

261V

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

262P

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

327K

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)

353K

beta/alpha domain interface
2R, 200D, 254N, 255E, 257Q, 258T, 259N, 261V, 262P, 327K, 353K
CDD
cd02186 (alpha_tubulin)
nucleotide binding...

11Q

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

12A

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

15Q

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

72E

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

102N

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

144G

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

145G

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

146T

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

147G

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

172V

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

207N

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

225Y

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)

229N

nucleotide binding site
11Q, 12A, 15Q, 72E, 102N, 144G, 145G, 146T, 147G, 172V, 207N, 225Y, 229N
CDD
cd02186 (alpha_tubulin)
alpha/beta domain ...

73P

alpha/beta domain interface
73P, 74N, 101A, 102N, 103N, 106R, 182V, 184E, 225Y
CDD
cd02186 (alpha_tubulin)

74N

alpha/beta domain interface
73P, 74N, 101A, 102N, 103N, 106R, 182V, 184E, 225Y
CDD
cd02186 (alpha_tubulin)

101A

alpha/beta domain interface
73P, 74N, 101A, 102N, 103N, 106R, 182V, 184E, 225Y
CDD
cd02186 (alpha_tubulin)

102N

alpha/beta domain interface
73P, 74N, 101A, 102N, 103N, 106R, 182V, 184E, 225Y
CDD
cd02186 (alpha_tubulin)

103N

alpha/beta domain interface
73P, 74N, 101A, 102N, 103N, 106R, 182V, 184E, 225Y
CDD
cd02186 (alpha_tubulin)

106R

alpha/beta domain interface
73P, 74N, 101A, 102N, 103N, 106R, 182V, 184E, 225Y
CDD
cd02186 (alpha_tubulin)

182V

alpha/beta domain interface
73P, 74N, 101A, 102N, 103N, 106R, 182V, 184E, 225Y
CDD
cd02186 (alpha_tubulin)

184E

alpha/beta domain interface
73P, 74N, 101A, 102N, 103N, 106R, 182V, 184E, 225Y
CDD
cd02186 (alpha_tubulin)

225Y

alpha/beta domain interface
73P, 74N, 101A, 102N, 103N, 106R, 182V, 184E, 225Y
CDD
cd02186 (alpha_tubulin)

Protein sequence

>MCA_02976_1
MREVISINVGQAGCQIGNSCWELYCLEHGIQPDGYRSTDRPEGGVRDEGFSTFFSETGSGKYVPRTIYVDLEPNVVDEVR
TGKYRDLFHPEQLITGKEDAANNYARGHYTVGKELIDDVVDRVRRVADNCNGLQGFLFTHSFGGGTGSGFGALLLERLSV
EFGKKSKLEFAVYPAPQNSTSVVEPYNSVLTTHATLEHSDCTFMVDNEAIYDMCRRSLDIPRPSYGNLNRLIAQVVSSVT
ASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVTYAPVLSAAKANHEANSVQEITSACFEPTHQMVKCDPRNGKYMATCLLY
RGDVVNKDVQQAVASIKSKKAIQLVDWCPTGFKIGICYQRPQYVPGGDLAKVDRAVCMLSNTTAIAEAWSRLDHKFDLMY
SKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVGADSPYDDEAEY

GO term prediction

Biological Process

GO:0007017 microtubule-based process

Molecular Function

GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding

Cellular Component

GO:0005874 microtubule

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Entry type

Status

Per-residue features