Protein

MCA_02923_1

Length
555 amino acids

Browser: contigB:2795120-2796788-

RNA-seq: read pairs 10309, FPKM 229.1, percentile rank 89.5% (100% = highest expression)

Protein function

KEGG:K03242EIF2S3 translation initiation factor 2 subunit 3
EGGNOG:0PFEJFG06843.1Translation initiation factor
SGD closest match:S000000827GCD11Eukaryotic translation initiation factor 2 subunit gamma
CGD closest match:CAL0000197613GCD11Translation initiation factor eIF2 subunit gamma

Protein alignments

%idAln lengthE-value
MIA_03201_181.40%5590.0MIA_03201_1
A0A0J9XDA8_GEOCN74.77%5550.0Similar to Saccharomyces cerevisiae YER025W GCD11 Gamma subunit of the translation initiation factor eIF2 OS=Geotrichum candidum GN=BN980_GECA09s00186g PE=4 SV=1
A0A167FT03_9ASCO80.29%4870.0Translation initiation factor eIF2 subunit gamma OS=Sugiyamaella lignohabitans GN=GCD11 PE=4 SV=1
Q6CHX3_YARLI71.17%5550.0YALI0A03839p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A03839g PE=4 SV=1
A0A060SZ84_BLAAD70.59%5610.0ARAD1A18458p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A18458g PE=4 SV=1
A0A1E3PSH8_9ASCO80.04%4810.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_20678 PE=4 SV=1
Q5AGF6_CANAL76.97%4820.0Translation initiation factor eIF2 subunit gamma OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GCD11 PE=4 SV=1
UniRef50_A5E2U877.23%4830.0Eukaryotic translation initiation factor 2 gamma subunit n=13 Tax=Eukaryota TaxID=2759 RepID=A5E2U8_LODEL
IF2G_YEAST70.76%5540.0Eukaryotic translation initiation factor 2 subunit gamma OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCD11 PE=1 SV=1
A0A1E4TCH2_9ASCO76.83%4790.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4078 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0179

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 555

Detailed signature matches

  1. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  2. Domain IPR000795
    Transcription factor, GTP-binding domain
    1. PS51722 (G_TR_2)
    2. PF00009 (GTP_EFTU)
    3. PR00315 (ELONGATNFCT)
  3. Domain IPR009000
    Translation protein, beta-barrel domain
    1. SSF50447 (Translati...)
  4. Domain IPR004161
    Translation elongation factor EFTu-like, domain 2
    1. PF03144 (GTP_EFTU_D2)
  5. Domain IPR009001
    Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    1. SSF50465 (EF-Tu/eEF...)
  6. Domain IPR015256
    Translation initiation factor 2, gamma subunit, C-terminal
    1. PF09173 (eIF2_C)
    2. cd15490 (eIF2_gamma...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.30.10
  2. G3DSA:3.40.50...
  3. cd01888 (eIF2_gamma)
  4. cd03688 (eIF2_gamma_II)
  5. mobidb-lite (disord...)

Residue annotation

  1. G1 box cd01888
  2. putative GEF inter...
  3. GTP/Mg2+ binding s...
  4. Switch I region cd...
  5. G2 box cd01888
  6. zinc binding site ...
  7. G3 box cd01888
  8. Switch II region c...
  9. G4 box cd01888
  10. G5 box cd01888
  11. tRNA binding site ...
  12. GTP binding site c...
  13. EF1alpha interface...
  14. tRNA binding site ...

Protein sequence

>MCA_02923_1
MSELQEQTPDIVIGNFDYANENQPSEELSDVEQEEQVESSTAADKPTEEENTTNSIAAEQSATTEESSQSAPKKSVSFAG
IDKDGLTEEERRQKEFEEGGGLPAQPDNPDFSKLTTLSPEIIGRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELE
RNITIRLGYANAKIYRCDNKDCPRPACYKSFSSGKEVSPKCEAPGCTGRYKLLRHVSFVDCPGHDILMSTMLSGAAVMDA
ALLLIAGNEPCPQPQTSEHLAAIDIMKLKHIIILQNKVDLIKEDQAMEHYKSIVKFVRGTPANGAPIVPISAQLKYNIDA
VNEFIVNKIPVPMRDLSVKPKLIVIRSFDVNKPGADIEDLKGGVAGGSILNGVLRLNDEIEIRPGILEKGDKGEIICRPI
RSKIVTLFAEHNDLKFAVPGGLIGVGTKIDPTLCRADRLVGQVLGHRGFLPDIYIELEVNYFLLRKLLGVKTENKKSAKV
EKLAKGESLMVNIGSTTSGARVVGVRADMAKLVLNTPSCTEIGEKIALSRRIAKHWRLIGWGEIKSGTTLNPVDY

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component

None predicted.