MCA_02881_1

Protein

Length

572 amino acids

RNA-seq: read pairs 140, FPKM 3.0, percentile rank 13.8% (100% = highest expression)

Protein function

EGGNOG:	0PG9P		MFS monocarboxylate transporter
SGD closest match:	S000005833	MCH5	Riboflavin transporter MCH5
CGD closest match:	CAL0000180528	orf19.2751	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_04594_1	52.34%	449	1e-139	MIA_04594_1
A0A060TC07_BLAAD	31.22%	394	4e-49	ARAD1D36124p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D36124g PE=4 SV=1
UniRef50_A0A060TC07	31.22%	394	1e-45	ARAD1D36124p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060TC07_BLAAD
A0A0J9X5D0_GEOCN	28.17%	458	3e-46	Similar to Saccharomyces cerevisiae YOR306C MCH5 Plasma membrane riboflavin transporter, facilitates the uptake of vitamin B2 OS=Geotrichum candidum GN=BN980_GECA03s01506g PE=4 SV=1
A0A167FRE1_9ASCO	29.44%	394	6e-44	Mch5p OS=Sugiyamaella lignohabitans GN=MCH5 PE=4 SV=1
A0A1E3PKI5_9ASCO	28.86%	395	2e-43	MFS general substrate transporter (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83425 PE=4 SV=1
A0A1E4TLK5_9ASCO	26.40%	375	8e-30	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1237 PE=4 SV=1
Q6CDG0_YARLI	25.05%	455	6e-26	YALI0C00825p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C00825g PE=4 SV=1
A0A1D8PLJ9_CANAL	23.88%	402	2e-14	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2751 PE=4 SV=1
MCH5_YEAST	21.36%	398	4e-13	Riboflavin transporter MCH5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCH5 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0269

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
124 - 560
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 572

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  129 - 524
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  279 - 560
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  127 - 249
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  124 - 559
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

500 - 510

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

180 - 190

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

437 - 447

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 119

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

564 - 572

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

246 - 280

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

334 - 383

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

374 - 562

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

114 - 344

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

407 - 417

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

468 - 472

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

532 - 542

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

211 - 215

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

142 - 160

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

301 - 311

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

280 - 302

TMHMM
TMhelix (TMhelix)

443 - 465

TMHMM
TMhelix (TMhelix)

312 - 334

TMHMM
TMhelix (TMhelix)

475 - 497

TMHMM
TMhelix (TMhelix)

223 - 245

TMHMM
TMhelix (TMhelix)

186 - 208

TMHMM
TMhelix (TMhelix)

157 - 179

TMHMM
TMhelix (TMhelix)

414 - 436

TMHMM
TMhelix (TMhelix)

382 - 404

TMHMM
TMhelix (TMhelix)

510 - 532

TMHMM
TMhelix (TMhelix)

120 - 142

TMHMM
TMhelix (TMhelix)

542 - 564

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

312 - 333

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

281 - 300

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

191 - 210

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

418 - 436

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

161 - 179

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

384 - 406

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

120 - 141

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

216 - 245

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

543 - 563

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

473 - 499

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

511 - 531

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

448 - 467

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 33

MobiDB Lite
mobidb-lite (disorder_prediction)

62 - 86

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

138W

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

141Y

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

142G

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

143V

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

145K

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

146N

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

165G

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

169I

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

170F

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

173N

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

177I

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

178F

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

180S

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

181N

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

228C

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

229A

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

232T

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

233S

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

236I

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

237P

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

240N

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

283V

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

284G

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

287S

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

288T

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

294G

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

395Q

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

398L

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

399Y

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

402A

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

403F

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

406S

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

419A

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

423L

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

427N

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

430A

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

434R

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

481G

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

484S

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

485G

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

488M

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

492N

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

493M

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

496G

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

508R

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

509T

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

512G

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

513S

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

516G

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

517S

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

520I

putative substrate translocation pore
138W, 141Y, 142G, 143V, 145K, 146N, 165G, 169I, 170F, 173N, 177I, 178F, 180S, 181N, 228C, 229A, 232T, 233S, 236I, 237P, 240N, 283V, 284G, 287S, 288T, 294G, 395Q, 398L, 399Y, 402A, 403F, 406S, 419A, 423L, 427N, 430A, 434R, 481G, 484S, 485G, 488M, 492N, 493M, 496G, 508R, 509T, 512G, 513S, 516G, 517S, 520I
CDD
cd06174 (MFS)

Protein sequence

>MCA_02881_1
MNINTSENKIEDKSNYSKSISPKSSISSDDIDLEKQDQHSIHKYYIDERDIVNEKHNNEHIETKTTHSSSSTSSSNDSSQ
EHQHPQIYQEPVQTLQRSNTLQSILSTTSISSLAKKAKRVIIQWAQVFGAFMLMINSWGWYGVFKNFYNSELLSDRSLFN
IAWIGSLHIFLVNIIGIFVSNRMVRAGYVKYSVGIAIIIVTFGMIMVSLSKEYYQIILAQGIVMGVGCAFSTSAAIPTVN
AYFAYTPTKYTNQNKQHDEAREKLSFIAKFKLKYHMYRKSLAVGLASTGGALGGIIYPTMGLELIPKLTFQQAAQVIAAL
IFGTSIASVFLLLPVPDAPPRSHWNWVSHWKSEGRNPSFLSSISSFLAVSQLLDDWTAFHDINFILFAAGLLLFQAGLYV
PAFFISQFGVAYGASVDYALYLLPVLNSGAVVGRFLPGFMAQIMGPLNAISVSIVGCVTIAWAWLSVKSSPNIAIFAVAY
GFLSGTFMALPNMCFGAMAPSAKVAGKRTNLGSIIGSLGILIGPPLGGLLIIEGDTIFTDCQYYTAVLMTTGGILMIASR
MTFTKGKFRIKA

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features