Protein

MCA_02755_1

Length
1,463 amino acids

Gene name: NIK1

Description: Histidine protein kinase NIK1

Browser: contigB:2280268-2284660-

RNA-seq: read pairs 3440, FPKM 29.0, percentile rank 51.8% (100% = highest expression)

Protein function

Annotation:NIK1Histidine protein kinase NIK1
KEGG:K19691NIK1 osomolarity two-component system, sensor histidine kinase NIK1 [EC:2.7.13.3]
EGGNOG:0PF99NIK1Histidine kinase
SGD closest match:S000001409SLN1Osmosensing histidine protein kinase SLN1
CGD closest match:CAL0000187540NIK1Histidine protein kinase NIK1

Protein alignments

%idAln lengthE-value
MIA_01829_196.18%9950.0MIA_01829_1
A0A0J9X503_GEOCN83.53%11660.0Similar to Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade OS=Geotrichum candidum GN=BN980_GECA02s01605g PE=4 SV=1
A0A060TCU2_BLAAD95.36%9690.0ARAD1D02266p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D02266g PE=4 SV=1
A0A167E0V0_9ASCO94.56%9740.0Sln1p OS=Sugiyamaella lignohabitans GN=SLN1 PE=4 SV=1
Q6C775_YARLI92.86%9660.0YALI0E03168p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E03168g PE=4 SV=1
A0A1E3PL21_9ASCO87.33%9630.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82976 PE=4 SV=1
A0A1E4TFT3_9ASCO76.97%9770.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31477 PE=4 SV=1
NIK1_CANAL74.43%9660.0Histidine protein kinase NIK1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NIK1 PE=1 SV=3
UniRef50_Q5A59974.43%9660.0Histidine protein kinase NIK1 n=30 Tax=Fungi TaxID=4751 RepID=NIK1_CANAL
SLN1_YEAST30.46%3715e-28Osmosensing histidine protein kinase SLN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLN1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0207

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 200 400 600 800 1000 1200 1463

Detailed signature matches

  1. Domain IPR008979
    Galactose-binding domain-like
    1. G3DSA:2.60.12...
  2. Domain IPR003660
    HAMP domain
    1. PS50885 (HAMP)
    2. SM00304 (HAMP_11)
    3. cd06225 (HAMP)
    4. PF00672 (HAMP)
  3. Domain IPR003661
    Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
    1. cd00082 (HisKA)
    2. SSF47384 (Homodimer...)
    3. SM00388 (HisKA_10)
    4. PF00512 (HisKA)
  4. Domain IPR005467
    Histidine kinase domain
    1. PS50109 (HIS_KIN)
  5. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. PF02518 (HATPase_c)
    3. SSF55874 (ATPase do...)
    4. SM00387 (HKATPase_4)
  6. Domain IPR004358
    Signal transduction histidine kinase-related protein, C-terminal
    1. PR00344 (BCTRLSENSOR)
  7. Domain IPR011006
    CheY-like superfamily
    1. SSF52172 (CheY-like)
  8. Domain IPR001789
    Signal transduction response regulator, receiver domain
    1. PS50110 (RESPONSE_R...)
    2. PF00072 (Response_reg)
    3. cd00156 (REC)
    4. SM00448 (REC_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.28...
  2. G3DSA:3.40.50...
  3. SSF58104 (Methyl-ac...)
  4. cd00075 (HATPase_c)
  5. mobidb-lite (disord...)

Residue annotation

  1. dimerization inter...
  2. dimerization inter...
  3. dimerization inter...
  4. dimerization inter...
  5. dimer interface cd...
  6. phosphorylation si...
  7. ATP binding site c...
  8. Mg2+ binding site ...
  9. G-X-G motif cd00075
  10. active site cd00156
  11. phosphorylation si...
  12. intermolecular rec...
  13. dimerization inter...

Protein sequence

>MCA_02755_1
MSTFPHYTNRPQQLQTTQDCSCDCSCDCCISNEETFLLLNDVITSISQYILENKSKISNSPVGSSLNDSSSLSSPYFKEP
ISNDVTNDSDHSKTSSYWTLSPHKAYSNHTSAHSQSELRKGSRNHLSSVNKKVNATNNSKITERYEKLLSIFPGVAPKKT
VPNSNHSTSSTSIPQLPQNLPGSATHLKTLLLNNIESLVSTTRDCFENNDAHDIQSSHLILDSFNTSPVKKQISNDSPSQ
RISTSTKDSENDIADSPSATLNLVQTIPSNDIPSDKTPRLEFSQEEKIKKLTDQLDLYKSAFGDISETNLKVISSGSQPM
PISSTPSSDDRYLLELTKSQNANKAFQKALREIGEVVIAVAQGDLSKKVTIHAQEMDPEILKFKETINTMMDQLQRFANE
VTKVATEVAGGTLGGQAESEGTVGVWRELTDNVNVMASNLTNQVREIADVTRAVARGDLSRKINVHAQGEILELQKTINT
MVDQLRTFAIEVTRVARETGVEGRLGGQAQIEGVEGIWRELTDNVNAMASNLTDQVRNIANVTTAVARGDLSQKVSADCK
GEILDLKSTINKMVDRLQNFATEVTTLARSVGTEGILGGQAKVEDVEGAWKEITENVNVMASNLTTQVRSIAHVTTAVAQ
GDLSQKIDVHAQGEMLALKSTINKMVDRLQLFASEVTRVAKDVGIDGKLGVQAQVSDVDGLWKEITTNVNTMAANLTSQV
RAFAQITAAATDGDFTSFITVEASGEMDALKTKINQMVLNLRESLQRNTAAREAAELANRAKSEFLANMSHEIRTPMNGI
IGMTQLTLDTELTQYQREMLSIVHNLANSLLTIIDDILDISKIEANRMTIEKIAFSLRGTVFGALKTLAVKANEKPLDLV
YKVDNTFPDNLVGDSFRLRQVILNLVGNAIKFTESGEVALRVRKADDQSCCEPDEMMIEFCVSDTGIGIQGDKLDVIFDT
FCQADGSTTRKFGGTGLGLSISKRLINLMGGDIWVKSELGKGSQFYFTLAVQPAETGLTQLLESIAPFRNHFVLFIDTVH
EKEVTEQLVENMAKLHLNAWVVHSVEEAPLPEDRTGPKFDTIIVDTLEVATKLRTLNHLKYIPLVLLNPCIPQVNLKLCL
DLGITSYGNTPCSVHDIGNVLRPALESRAAPLNSDGAKQFHILLAEDNVVNQKLAVRILEKYKHKVEVVENGREAFEAIK
RKRYDVVLMDVQMPVMGGFEATAKIREWEKQNITVRTRTPIVALTAHAMLGDRERCMQAQMDEYLSKPLKPALLVQTINK
CVHSVNQLRSLALGPTSAANGGMSKGYGVGTSIEETIGPANHDYSTPSSSTPSSSNGSSIGQAPVQTRSNSTPTIHNESF
TSSSTNNSTSLINSSSNQVQQQAKMQQNKRPEMNHRAATVSDLRNSRIEILDEPLPTNPAPKNGDLESTTKLKPLATINN
NQDNEKDPKSVVSISVKDGEKND

GO term prediction

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0004871 signal transducer activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

GO:0016021 integral component of membrane