Protein

MCA_02743_1

Length
699 amino acids

Gene name: TRP5

Description: Tryptophan synthase

Browser: contigB:2233114-2235325+

RNA-seq: read pairs 5541, FPKM 97.8, percentile rank 78.2% (100% = highest expression)

Protein function

Annotation:TRP5Tryptophan synthase
KEGG:K01694TRP tryptophan synthase [EC:4.2.1.20]
EGGNOG:0PFFQTRP5tryptophan synthase
SGD closest match:S000002994TRP5Tryptophan synthase
CGD closest match:CAL0000186632TRP5Tryptophan synthase

Protein alignments

%idAln lengthE-value
MIA_05480_173.14%7000.0MIA_05480_1
A0A0J9XGF5_GEOCN72.33%7010.0Tryptophan synthase OS=Geotrichum candidum GN=BN980_GECA15s00802g PE=3 SV=1
UniRef50_A0A1S7HVT165.62%7040.0Tryptophan synthase n=10 Tax=saccharomyceta TaxID=716545 RepID=A0A1S7HVT1_9SACH
A0A1D8PMH6_CANAL66.95%6990.0Tryptophan synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TRP5 PE=3 SV=1
A0A1E3PE16_9ASCO66.19%7010.0Tryptophan synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84593 PE=3 SV=1
TRP_YEAST65.30%7060.0Tryptophan synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRP5 PE=1 SV=1
A0A167EUM8_9ASCO64.61%6980.0Tryptophan synthase OS=Sugiyamaella lignohabitans GN=TRP5 PE=3 SV=1
Q6C0G7_YARLI65.76%6980.0Tryptophan synthase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F24893g PE=3 SV=1
A0A060SZ60_BLAAD62.36%6960.0Tryptophan synthase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C02728g PE=3 SV=1
A0A1E4TFS5_9ASCO61.01%6950.0Tryptophan synthase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_108493 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7092

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 699

Detailed signature matches

  1. Family IPR002028
    Tryptophan synthase, alpha chain
    1. PF00290 (Trp_syntA)
    2. TIGR00262
    3. cd04724 (Tryptophan...)
    4. MF_00131 (Trp_synth...)
  2. Family IPR023026
    Tryptophan synthase beta chain/beta chain-like
    1. MF_00133 (Trp_synth...)
  3. Family IPR006654
    Tryptophan synthase, beta chain
    1. cd06446 (Trp-synth_B)
    2. TIGR00263
  4. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  5. Domain IPR011060
    Ribulose-phosphate binding barrel
    1. SSF51366 (Ribulose-...)
  6. Domain IPR001926
    Tryptophan synthase beta subunit-like PLP-dependent enzyme
    1. SSF53686 (Tryptopha...)
    2. PF00291 (PALP)
  7. SITE IPR018204
    Tryptophan synthase, alpha chain, active site
    1. PS00167 (TRP_SYNTHA...)
  8. SITE IPR006653
    Tryptophan synthase, beta chain, conserved site
    1. PS00168 (TRP_SYNTHA...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...

Residue annotation

  1. catalytic residues...
  2. active site cd04724
  3. substrate binding ...
  4. heterodimer interf...
  5. pyridoxal 5'-phosp...
  6. catalytic residue ...

Protein sequence

>MCA_02743_1
MASLIRHTFERCKKEQRPALVAFLTSGFPTEEDTPALLKALQDGGADVIELGIPFTDPIADGPTIQYANNVALAGGMTTA
KSIANVAKARALGVTIPILLMGYYNPVLQYGDAKLIADSKEAGVNGFILVDLPPEEAINFRAVCSQQGLSYIPLVAPATT
NERLQQLAPIADSFIYVASRMGTTGVRGSLEESLPELLERVKKFTKDIPLAVGFGISTKEHFDDVGSHADGVVIGSKIIT
TIDEQKTAEARVEAVKKYISSVAATDRTVTPLTVEEYNTVLKNGEHVAGEAVEHPLVTQFGQYGGQYVPEAMHQCFRELE
KGFEDAIKSEEFWEEFRSYYPYMGRPSSLHKAERLTEYAGGAQIWLKREDLNHTGSHKINNALGQILIAKRLGKKNIIAE
TGAGQHGVATATVAAKFGMKCTIYMGAEDVRRQALNVFRIRMLGAEVVPVEIGSKTLRDAVNEAFRHWVTNVDDTHYVIG
SAIGPHPYPTIVKTFQSVIGQEARKTFMELNEGRLPDYVIACVGGGSNCVGMFSPFENDKSVKLRGIEAGGDGIDTARHS
ATLTKGHKGVLHGVKTYVLQNSDGQVEDTHSISAGLDYPGVGPQLAYWKETGRAEFVAADDAQALLGFKLSTQLEGIIPA
LESSHAIYGAIELAKTLKPDQHIIVCLSGRGDKDVHSVAENLPTLGPKIGWDLRFEGNL

GO term prediction

Biological Process

GO:0000162 tryptophan biosynthetic process
GO:0006568 tryptophan metabolic process
GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004834 tryptophan synthase activity

Cellular Component

None predicted.