MCA_02597_1

Protein

Length

350 amino acids

Gene name: ECM31

Description: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Browser: contigB:1779858-1781147+

RNA-seq: read pairs 420, FPKM 14.8, percentile rank 33.8% (100% = highest expression)

Protein function

Annotation:		ECM31	3-methyl-2-oxobutanoate hydroxymethyltransferase
KEGG:	K00606	panB	3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]
EGGNOG:	0PHZX	FG09312.1	3-methyl-2-oxobutanoate hydroxymethyltransferase
SGD closest match:	S000000380	ECM31	3-methyl-2-oxobutanoate hydroxymethyltransferase
CGD closest match:	CAL0000175867	orf19.6057	3-methyl-2-oxobutanoate hydroxymethyltransferase

Protein alignments

	%id	Aln length	E-value
MIA_01046_1	72.87%	328	6e-165	MIA_01046_1
A0A1E3PRL4_9ASCO	66.02%	309	3e-142	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81143 PE=3 SV=1
A0A167F564_9ASCO	64.67%	300	2e-137	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Sugiyamaella lignohabitans GN=ECM31 PE=3 SV=1
A0A0J9X3N5_GEOCN	64.98%	297	1e-136	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Geotrichum candidum GN=BN980_GECA02s01066g PE=3 SV=1
A0A060T9E1_BLAAD	60.87%	322	2e-135	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D17138g PE=3 SV=1
Q6CE35_YARLI	61.74%	298	5e-128	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B18898g PE=3 SV=1
UniRef50_A0A197K3E5	51.74%	344	2e-108	3-methyl-2-oxobutanoate hydroxymethyltransferase n=4 Tax=Fungi TaxID=4751 RepID=A0A197K3E5_9FUNG
Q5ABB3_CANAL	48.17%	301	6e-91	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6057 PE=3 SV=1
A0A1E4TC36_9ASCO	47.67%	279	7e-88	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_138323 PE=3 SV=1
PANB_YEAST	41.94%	279	4e-63	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM31 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9955
Predicted cleavage: 55

Protein family membership

Ketopantoate hydroxymethyltransferase (IPR003700)

Domains and repeats

Domain
67 - 328
Pyruvate/Phosphoenolpyruvate kinase-like domain (IPR015813)

1 50 100 150 200 250 300 350 350

Detailed signature matches

IPR003700

Ketopantoate hydroxymethyltransferase
1. MF_00156 (PanB)
  
  67 - 328
  
  HAMAP
  MF_00156 (PanB)
2. cd06557 (KPHMT-like)
  
  69 - 322
  
  CDD
  cd06557 (KPHMT-like)
3. TIGR00222
  
  68 - 328
  
  TIGRFAMs
  TIGR00222 (TIGR00222)
4. PF02548 (Pantoate_t...)
  
  67 - 323
  
  Pfam
  PF02548 (Pantoate_transf)
IPR015813

Pyruvate/Phosphoenolpyruvate kinase-like domain
1. SSF51621 (Phosphoen...)
  
  67 - 328
  
  SUPERFAMILY
  SSF51621 (Phosphoenolpyruvate/pyruvate domain)

no IPR

Unintegrated signatures

G3DSA:3.20.20.60

52 - 328

GENE3D
G3DSA:3.20.20.60 (G3DSA:3.20.20.60)
NON_CYTOPLASM... (N...)

20 - 350

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 19

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

15 - 19

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

7 - 14

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 6

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)

Residue annotation

oligomerization in...

69V

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

70V

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

89D

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

90Y

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

91I

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

92S

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

95L

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

110L

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

112M

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

113V

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

114A

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

115L

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

116G

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

117Y

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

121N

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

122E

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

127E

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

130Y

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

131H

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

134A

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

137R

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

150F

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

151G

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

161V

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

165I

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

168V

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

169K

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

174H

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

192T

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

193S

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

194V

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

195G

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

196I

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

197P

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

207Q

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

208R

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

210A

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

211S

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

212L

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

213G

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

241F

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

281L

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

284L

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

285G

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

299S

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

302L

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

303K

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

304I

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

305N

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)

306T

oligomerization interface
69V, 70V, 89D, 90Y, 91I, 92S, 95L, 110L, 112M, 113V, 114A, 115L, 116G, 117Y, 121N, 122E, 127E, 130Y, 131H, 134A, 137R, 150F, 151G, 161V, 165I, 168V, 169K, 174H, 192T, 193S, 194V, 195G, 196I, 197P, 207Q, 208R, 210A, 211S, 212L, 213G, 241F, 281L, 284L, 285G, 299S, 302L, 303K, 304I, 305N, 306T
CDD
cd06557 (KPHMT-like)
active site cd06557

86T

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

105L

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

107G

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

108D

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

109S

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

147D

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

177K

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

201H

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

206P

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

246E

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

277V

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)

279V

active site
86T, 105L, 107G, 108D, 109S, 147D, 177K, 201H, 206P, 246E, 277V, 279V
CDD
cd06557 (KPHMT-like)
metal binding site...

108D

metal binding site
108D, 147D, 177K
CDD
cd06557 (KPHMT-like)

147D

metal binding site
108D, 147D, 177K
CDD
cd06557 (KPHMT-like)

177K

metal binding site
108D, 147D, 177K
CDD
cd06557 (KPHMT-like)

Protein sequence

>MCA_02597_1
MTLSRKIISTLTCLGKTSATLIPTTRCSTQGLIRATARQPALAPRVFSRFSHYDSPSENNKASRPPVTVVDIQKLYKNKV
PISVLTAHDYISAILADRAGVDIILVGDSLSMVALGYEDTNEIELDEMIYHARAVSRGSKSAFLIADLPFGSYEISPDQA
VASAIQMVKRGKMHGIKIEGGIENYETIKKLTSVGIPVMGHVGLTPQRQASLGGFKVQGKTAQSAESILQDALALQKAGC
FAIVLEAMPEPIASLITSKLSVPTIGIGAGAGTSGQVLVQLDMLGGFDGFTPKFLKKYSNYLKINTEAIQDYVNEVKNGQ
YPQKEHCYSVKQEQVDKFKEILEAKYADQK

GO term prediction

Biological Process

GO:0015940 pantothenate biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features