Protein

MCA_02585_1

Length
1,456 amino acids

Gene name: PDR5E

Description: plasma membrane ATP-binding cassette (ABC) transporter; involved in multidrug resistance

Browser: contigB:1733215-1737774-

RNA-seq: read pairs 118, FPKM 1.0, percentile rank 9.2% (100% = highest expression)

Protein function

Annotation:PDR5Eplasma membrane ATP-binding cassette (ABC) transporter; involved in multidrug resistance
EGGNOG:0PFN7PGUG_04203(ABC) transporter
SGD closest match:S000005679PDR5Pleiotropic ABC efflux transporter of multiple drugs
CGD closest match:CAL0000201396CDR4Cdr4p

Protein alignments

%idAln lengthE-value
MIA_01039_164.42%14420.0MIA_01039_1
A0A0J9XKE4_GEOCN60.89%14140.0Similar to Saccharomyces cerevisiae YDR011W SNQ2 Plasma membrane ATP-binding cassette (ABC) transporter OS=Geotrichum candidum GN=BN980_GECA23s00131g PE=3 SV=1
A0A060T914_BLAAD54.40%14670.0ARAD1D07634p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D07634g PE=3 SV=1
UniRef50_A0A060T91454.40%14670.0ARAD1D07634p n=220 Tax=Dikarya TaxID=451864 RepID=A0A060T914_BLAAD
Q6CET9_YARLI53.43%14430.0YALI0B12980p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12980g PE=3 SV=1
A0A1E4TEV9_9ASCO53.11%14160.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_103973 PE=3 SV=1
A0A161HI40_9ASCO50.97%14460.0ATP-binding cassette multidrug transporter PDR5 OS=Sugiyamaella lignohabitans GN=PDR5 PE=3 SV=1
A0A1D8PE84_CANAL49.75%14150.0Cdr4p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDR4 PE=3 SV=1
PDR5_YEAST48.81%14340.0Pleiotropic ABC efflux transporter of multiple drugs OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDR5 PE=1 SV=1
A0A1E3PD79_9ASCO41.67%13680.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84369 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0119

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1456

Detailed signature matches

  1. Domain IPR029481
    ABC-transporter extracellular N-terminal domain
    1. PF14510 (ABC_trans_N)
  2. Domain IPR003439
    ABC transporter-like
    1. PF00005 (ABC_tran)
    2. PS50893 (ABC_TRANSP...)
  3. Domain IPR034001
    ATP-binding cassette transporter, PDR-like subfamily G, domain 1
    1. cd03233 (ABCG_PDR_d...)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
  6. Domain IPR013525
    ABC-2 type transporter
    1. PF01061 (ABC2_membrane)
  7. Domain IPR010929
    CDR ABC transporter
    1. PF06422 (PDR_CDR)
  8. Domain IPR034003
    ATP-binding cassette transporter, PDR-like subfamily G, domain 2
    1. cd03232 (ABCG_PDR_d...)
  9. SITE IPR017871
    ABC transporter, conserved site
    1. PS00211 (ABC_TRANSP...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:1.20.12...
  4. G3DSA:3.40.50...
  5. NON_CYTOPLASM... (N...)
  6. TMhelix
  7. TRANSMEMBRANE (Tran...)

Protein sequence

>MCA_02585_1
MSDSNDVSDVERYHGEFIEMDENKFSDVASTISFPASLNPIINPDRASALDPSNPDFSFKNWAKHILKLQKSDPEKFPLL
EMGVSFKGLTAYGYEGGSNYQKTVLNILFDITKIPTLLFQNKKRKEKNKTELLHDFNGLVRSGETCVVLGRPGAGCSTFL
KSIACDTYGFHIDESSVINFQGLSQKDIRNHYRGEVVYNAENEVHYPYLTVGDTLKFAALARTPEIRFGDVTRDEYATHM
RDVVMASFGLLHTMNTRVGNDYVRGVSGGERRRISISEVTLGGALVQCFDNSTRGLDSSSALTFIQNAKVGAEISGATVF
ISLYQASQDAYDLFDKVTVLYLGRQIYFGPAKNAKKFFEDMGYVCIDRQTTGDFLTSLTSPAERVVKPGFEDKVPRTPDE
FEAYWKASPEYAQLMQEIEEFNTTYPIRSEEQLQISQTYKNAKQSKHARKKSPYFLSYWRQIQICIFRGFQRLKVDYVMT
LTSVIGNTIAALLVSSIFYNLPKDTGSFYHRSAALFFAVLFNALSSLLEVFALYSMRAIVEKHNKYAFYHPSAEAVSSLI
VDMPGKIVTTLAFNMVLYFMVNLRREPGPFFIFFLFAIMCVLTMSAMFRTIASVTKSVPQSLTPASFIIVMIITTMGFVI
PVVNMHPWIRWINYINPIAYAFEAMMINEYRNREFPCTSIIPSGGAYDSLPYDQRSCSVVGAKPGQTFVNGSDYIIESYE
YMPSHLWRNFGIIIAFCVFFHFTYFFFVEYIKGQRSKGEVLIFPRGHEAISNSSGKLQNIEDHYDEMDKKEESSGSEEGK
LSSQRGIFQWQDVCYDITIKGEPRRLLDHVDGWVKPGTLTALMGASGAGKTTLLDTLADRVTMGVVTGSMLVNGHQRDAS
FQRKTGYAQQQDVHMATSTVREALEFSALLRQPDTYTKEEKLAYVDEVIKILEMEKYSDAVVGVPGEGLNIEQRKRLTIG
VELAARPELLLFLDEPTSGLDSQTAWSIMMLMKKLTNSGQAILCTIHQPSAVLFQQFDRLLLLQKGGKTAYYGDLGDRAT
KMISYFERNGANPCPPDANPAEWMLDVIGAAPGAQTEQDWHEIWRNSPEYAQTREELARLAHQSAIDFPQTEQEQHLQKS
YALPILRQIPIVSKRAFLDTWRDPQYIWSKLILTMGLSLFLGIEFLNAENTIQGMQNQLYAIFMISVIFISMVEQLMTPF
VEHRTLYETRERPSKTYSWVTFMTSMFLAEAPWLIFSGTLSFIFFYYPVGFYRNARFTDSVSERGALFFLLYVIFYLFGL
SFAYLIIAAIPDADTGANINNLLFNICLIMSGVFATKEEMPGFWIFMYYLSPFRYIISAFLSTGISGAPVECAQRELTLF
PTTPEPGMTCGEFLGPYSNATQGRILNPEALSNCQYCTMSTTDTYLARINCKFEDAWRNFGIIILYTVFNVAMSYFFYWL
GRVPKPWSKKKVEKLE

GO term prediction

Biological Process

GO:0006810 transport

Molecular Function

GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances

Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane