Protein

MCA_02569_1

Length
1,156 amino acids

Gene name: DUG2

Description: Probable di- and tripeptidase DUG2; Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)

Browser: contigB:1677339-1680810+

RNA-seq: read pairs 1598, FPKM 17.1, percentile rank 37.1% (100% = highest expression)

Protein function

Annotation:DUG2Probable di- and tripeptidase DUG2; Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
KEGG:K14262DUG2 di- and tripeptidase [EC:3.4.-.-]
EGGNOG:0PIN5PGUG_05551WD repeat protein
SGD closest match:S000000485DUG2Probable di- and tripeptidase DUG2
CGD closest match:CAL0000201841orf19.2455Glutamine amidotransferase subunit

Protein alignments

%idAln lengthE-value
MIA_05355_164.13%10790.0MIA_05355_1
A0A0J9XGA9_GEOCN53.44%10030.0Similar to Saccharomyces cerevisiae YBR281C DUG2 Probable di-and tri-peptidase OS=Geotrichum candidum GN=BN980_GECA14s02672g PE=4 SV=1
UniRef50_A0A0J9XGA953.44%10030.0Similar to Saccharomyces cerevisiae YBR281C DUG2 Probable di-and tri-peptidase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGA9_GEOCN
A0A167FET0_9ASCO44.25%10260.0Glutamine amidotransferase subunit DUG2 OS=Sugiyamaella lignohabitans GN=DUG2 PE=4 SV=1
A0A060T998_BLAAD46.33%9000.0ARAD1C42394p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C42394g PE=4 SV=1
Q6C2N8_YARLI40.14%9790.0YALI0F06336p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F06336g PE=4 SV=1
A0A1D8PDN2_CANAL34.40%10610.0Glutamine amidotransferase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2455 PE=4 SV=1
DUG2_YEAST34.84%9960.0Probable di- and tripeptidase DUG2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DUG2 PE=1 SV=1
A0A1E3PD86_9ASCO39.42%8600.0Zn-dependent exopeptidase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84373 PE=4 SV=1
A0A1E4TH67_9ASCO33.06%9775e-177Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2807 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0792

Protein family membership

Domains and repeats

  1. Domain
  2. Repeat
  3. Repeat
1 200 400 600 800 1000 1156

Detailed signature matches

  1. Family IPR002933
    Peptidase M20
    1. PF01546 (Peptidase_M20)
  2. Family IPR017149
    Glutathione degradosome, Dug2
    1. PIRSF037237 (Peptid...)
  3. Domain IPR015943
    WD40/YVTN repeat-like-containing domain
    1. G3DSA:2.130.1...
  4. Domain IPR017986
    WD40-repeat-containing domain
    1. SSF50978 (WD40 repe...)
    2. PS50294 (WD_REPEATS...)
  5. Domain IPR011650
    Peptidase M20, dimerisation domain
    1. PF07687 (M20_dimer)
  6. Repeat IPR001680
    WD40 repeat
    1. PF00400 (WD40)
    2. PS50082 (WD_REPEATS_2)
    3. SM00320 (WD40_4)
  7. Repeat IPR020472
    G-protein beta WD-40 repeat
    1. PR00320 (GPROTEINBRPT)
  8. SITE IPR019775
    WD40 repeat, conserved site
    1. PS00678 (WD_REPEATS_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.30.70...
  3. G3DSA:3.40.63...
  4. SSF53187 (Zn-depend...)
  5. mobidb-lite (disord...)

Protein sequence

>MCA_02569_1
MSDTAADGCGSNGYSSSSPPSNPRSIPSRPSSTPINLSEPSHFNSKPNLSSKTSFSNIQSSGHAIHSTTQYNDFGCSRSS
PAPTATSSPNLGSTRNTGSMTNSVSPAHTGTTNPTTMYSHNFSTVPYSAAVGNVHSVSPSSIQYMRANTSSGHLQPYTFN
NSLSNSDEYWPITSNLAGHHLGMPRLVHAWRCPNSVLSLVSTKDWIIAGCGDGHIMIFSKETFVTVAVLPGHHPSTTTHS
TTHTNNQDYSGSSVYSLTITPDERFLFSAGADSLVKVWDLNTLNEIYVIYSVYDIGDIFSVAWIPRHEVLVFGAQNASIQ
WIKLYDKTSYTTTQDPNNLPSFRFDKFFDSKGPGGKMAPQQHQKRLLVAESDAKKRHSSTSDGPNNQNTPIDLLEIPPKN
VIQYAHYGYVYSLLVVNRKLSNYIKDNDEQDEYLVSGGGDGTVKFWSFQKDKGSFQAIYNFDVDLSIFSMCYYDNFLYLG
LNNGQVGLFDMDTRQTIRVDKVADEGDVMAMSLHGDCLFRGGAHGVIRKWDSKQYTRAEWAAHKGTVLSTVITNYSLSSK
VLISGGSDNIVSMWDITSMLESSGLPISINTSNVAPGLIQNSAMPNSLGQFQALVPQQSKQVATLTTDHMLRTLRDFVAY
QTVSGHDGIYANDCRRCAIFLRSLMRHFGADAQLIPVEDGNPIVVGVFKGGKSSSSSDNLKPQDITGKVKDLNISDDSLS
SKVKDSKCRILFYGHYDVIIADKTTDRWDTEPYEMCALDGYLYGRGVSDNKGPVLAAIFAVAELVQRSELENDVVFVIEG
EEECGSRGFQETIHKYRDYISGKTNCCVDSPNSMDTSISLESTNGILGSSNSALSTESVDPESEVDWVLLSNSYWLDDIT
PCLNYGLRGIIKANVVVKGIFPDLHSGVYGGTYREPTMDLVKLLSKLSTDDGTIILPALHDNVRPVDQEEKKLYDAILSK
TKLFDDKNAKIIFNDTSLSTDETVSDGMKQLMARWRYPSLTIHRIDVSGPGNSTLIPQCASATISLRIVPDQDIPDIKKD
LMSYLHEQFLSFKSSNELTVDIFHEADPWVGDITNKSFTVLKEAIEQEWGEPPIFIREGGSIPAVRFLEKEFNAPAAQLP
CGQASDGAHMNNERLRVMNFLKTRNVLEHTFKTLRK

GO term prediction

Biological Process

GO:0006751 glutathione catabolic process
GO:0008152 metabolic process

Molecular Function

GO:0005515 protein binding
GO:0016787 hydrolase activity

Cellular Component

None predicted.