Protein

MCA_02547_1

Length
929 amino acids

Gene name: MCM4

Description: DNA replication licensing factor MCM4; Essential helicase component of heterohexameric MCM2-7 complexes

Browser: contigB:1612442-1615293-

RNA-seq: read pairs 758, FPKM 10.1, percentile rank 26.0% (100% = highest expression)

Protein function

Annotation:MCM4DNA replication licensing factor MCM4; Essential helicase component of heterohexameric MCM2-7 complexes
KEGG:K02212MCM4 DNA replication licensing factor MCM4 [EC:3.6.4.12]
EGGNOG:0PHQMFG00504.1DNA replication licensing factor Mcm4
SGD closest match:S000006223MCM4DNA replication licensing factor MCM4
CGD closest match:CAL0000176876CDC54DNA helicase

Protein alignments

%idAln lengthE-value
A0A0J9XBP2_GEOCN66.39%8540.0DNA helicase OS=Geotrichum candidum GN=BN980_GECA07s01594g PE=3 SV=1
MIA_02920_166.02%8210.0MIA_02920_1
A0A060T7F8_BLAAD59.02%9150.0DNA helicase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B23540g PE=3 SV=1
A0A1E3PMM5_9ASCO62.60%7860.0DNA helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82943 PE=3 SV=1
A0A167E9Z4_9ASCO60.38%8530.0DNA helicase OS=Sugiyamaella lignohabitans GN=MCM4 PE=3 SV=1
UniRef50_A0A0E9NR9660.51%7850.0DNA helicase n=21 Tax=Dikarya TaxID=451864 RepID=A0A0E9NR96_9ASCO
MCM4_YEAST60.20%7840.0DNA replication licensing factor MCM4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCM4 PE=1 SV=2
A0A1D8PFE6_CANAL58.97%8360.0DNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDC54 PE=3 SV=1
Q6C2V4_YARLI53.32%9340.0DNA helicase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F04818g PE=3 SV=1
A0A1E4TBN0_9ASCO56.96%7900.0DNA helicase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_134438 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0427
Predicted cleavage: 89

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 929

Detailed signature matches

  1. Family IPR031327
    Mini-chromosome maintenance protein
    1. SM00350 (mcm)
  2. Family IPR008047
    Mini-chromosome maintenance complex protein 4
    1. PR01660 (MCMPROTEIN4)
  3. Domain IPR027925
    MCM N-terminal domain
    1. PF14551 (MCM_N)
  4. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  5. Domain IPR033762
    MCM OB domain
    1. PF17207 (MCM_OB)
  6. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  7. Domain IPR001208
    MCM domain
    1. PS50051 (MCM_2)
    2. PR01657 (MCMFAMILY)
    3. PF00493 (MCM)
  8. SITE IPR018525
    Mini-chromosome maintenance, conserved site
    1. PS00847 (MCM_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.8.300
  2. G3DSA:2.40.50...
  3. G3DSA:3.30.16...
  4. G3DSA:3.40.50...
  5. cd00009 (AAA)
  6. mobidb-lite (disord...)

Residue annotation

  1. Walker A motif cd0...
  2. ATP binding site c...
  3. Walker B motif cd0...
  4. arginine finger cd...

Protein sequence

>MCA_02547_1
MSTNGSSNNNNNDSNRQQRAAHTPSTDSGSSPLFYGSSPIVPARTPIGTTPRDRIHRLQSSSSRNVSSPLALSLSNDFSS
PRISMQRSRGDIFATESSQSRSHLHDPTDSSERNTYPMVSTPQALHSENDMPMSDRTVQEEDDVVRVIWGTNVTISEVIK
TFRDFLFDYKEKYRKLYDGETLAPGEGEDRVYRRTLEDMLKMGYTNFNLDLRNLEAYPPTRKLARQIVNYPQEVIPALDE
TLKECLIQIASEDPSISPSTIESEIESKAFKTRPFNISEERGMRDLDPTDVDKLISVSGLVLRSTPIIPDMKTAYFKCWM
CDYAVVVQIDRGTIQEPTTCPDCAAKNTMVLEHVRSTFADKQIVRLQETPNNVPDGQTPHSISVIMYDELVDVCRAGDRV
TLTGIFRSVPVRVSSRQRTLKSLYKTYVDVIHIKKTDKKRIGVDVSTLGNTHLEPRYATHIRGEDDDFMDEDPSEHDDIR
QQDAADTEEVRQISAEEIQKIHDTASRDDVYELLARSIAPSIFEQDDVKKGILLQLFGGTNKKFTKGGSPRYRGDINILL
CGDPSTSKSQILQYIHKIAPRGIYTSGKGSSAVGLTAYVTRDQETKQLVLESGALVLSDGGICCIDEFDKMNEGTRSVLH
EVMEQQTVSVAKAGIITTLNARTSILASANPIGSKYNPDLSVIQNIDLPPTLLSRFDLVYLMLDKVDSRADRQLARHLAS
MYLEDTPENASAYEVLPVEFLTVYISYAKEHIHPVILPEAKRELVDAYVEMRKMGDDIRANEKRITATTRQLESMIRLSE
AHAKMRLSRYVNKDDVKEAVRLIRSAIKDYATDPRTGRIDMSIVQTGTSMAQRMAQSTLKEEIIRIIDSMTHDGNTVRQA
EVIRKINEESSEHFSAFEVAEALRNLVQEGQIVVFGEGTRKSIRRAAGI

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0006270 DNA replication initiation

Molecular Function

GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0005524 ATP binding

Cellular Component

GO:0042555 MCM complex