Protein

MCA_02533_1

Length
216 amino acids

Gene name: ADE8

Description: Phosphoribosylglycinamide formyltransferase

Browser: contigB:1578388-1579039+

RNA-seq: read pairs 1318, FPKM 75.0, percentile rank 74.0% (100% = highest expression)

Protein function

Annotation:ADE8Phosphoribosylglycinamide formyltransferase
KEGG:K00601E2.1.2.2 phosphoribosylglycinamide formyltransferase [EC:2.1.2.2]
EGGNOG:0PNSUFG08429.1phosphoribosylglycinamide formyltransferase
SGD closest match:S000002816ADE8Phosphoribosylglycinamide formyltransferase
CGD closest match:CAL0000195096ADE8Phosphoribosylglycinamide formyltransferase

Protein alignments

%idAln lengthE-value
MIA_02886_175.24%2104e-115MIA_02886_1
A0A0J9XG00_GEOCN73.83%2147e-113Similar to Saccharomyces cerevisiae YDR408C ADE8 Phosphoribosyl-glycinamide transformylase OS=Geotrichum candidum GN=BN980_GECA14s01418g PE=3 SV=1
A0A060T210_BLAAD71.90%2107e-108ARAD1A03652p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03652g PE=4 SV=1
A0A167D360_9ASCO71.36%2137e-106Phosphoribosylglycinamide formyltransferase OS=Sugiyamaella lignohabitans GN=ADE8 PE=4 SV=1
A0A1E3PJC0_9ASCO69.01%2134e-103Phosphoribosyl-glycinamide transformylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50812 PE=4 SV=1
Q6CAG1_YARLI68.22%2141e-97YALI0D03069p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D03069g PE=3 SV=1
A0A1D8PGS7_CANAL61.16%2242e-90Phosphoribosylglycinamide formyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE8 PE=4 SV=1
UniRef50_A0A1D8PGS761.16%2246e-87Phosphoribosylglycinamide formyltransferase n=24 Tax=Saccharomycetales TaxID=4892 RepID=A0A1D8PGS7_CANAL
A0A1E4TGX7_9ASCO59.81%2148e-81Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2726 PE=3 SV=1
PUR3_YEAST56.48%2165e-70Phosphoribosylglycinamide formyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE8 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1687

Protein family membership

Domains and repeats

  1. Domain
1 20 40 60 80 100 120 140 160 180 200 216

Detailed signature matches

  1. Family IPR004607
    Phosphoribosylglycinamide formyltransferase
    1. cd08645 (FMT_core_GART)
    2. TIGR00639
    3. MF_01930 (PurN)
  2. Domain IPR002376
    Formyl transferase, N-terminal
    1. G3DSA:3.40.50...
    2. SSF53328 (Formyltra...)
    3. PF00551 (Formyl_tra...)
  3. SITE IPR001555
    Phosphoribosylglycinamide formyltransferase, active site
    1. PS00373 (GART)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)

Residue annotation

  1. active site cd08645
  2. substrate binding ...
  3. cosubstrate bindin...
  4. catalytic site cd0...

Protein sequence

>MCA_02533_1
MTKKVLVLISGSGTNLQALIDAAAQNKLGDGQISLVISSSPDAYGLERAKKANIPTYVHSLQSDKYYGKIPKTDKEARKE
ARKAFNKDLADYILLPENKPDLIVCAGWMLILSPTFLKPLEEAKIPIINLHPALPGAFAGTHAIERAWEAGQKGEITKGG
VMIHKVIAQVDEGEPLVVKEIELNKDETVEQYEDRVHKIEHVAIVEGTVKALNELA

GO term prediction

Biological Process

GO:0006189 'de novo' IMP biosynthetic process
GO:0009058 biosynthetic process

Molecular Function

GO:0004644 phosphoribosylglycinamide formyltransferase activity
GO:0016742 hydroxymethyl-, formyl- and related transferase activity

Cellular Component

None predicted.