Protein

MCA_02515_1

Length
1,068 amino acids

Gene name: GDH2

Description: NAD-specific glutamate dehydrogenase

Browser: contigB:1533652-1537018+

RNA-seq: read pairs 7012, FPKM 81.0, percentile rank 75.5% (100% = highest expression)

Protein function

Annotation:GDH2NAD-specific glutamate dehydrogenase
KEGG:K15371GDH2 glutamate dehydrogenase [EC:1.4.1.2]
EGGNOG:0QE6VGDH2glutamate dehydrogenase
SGD closest match:S000002374GDH2NAD-specific glutamate dehydrogenase
CGD closest match:CAL0000201467GDH2NAD-specific glutamate dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_05889_179.43%10840.0MIA_05889_1
A0A0J9X9K0_GEOCN74.17%10530.0NAD-specific glutamate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA06s00802g PE=3 SV=1
A0A060TI02_BLAAD72.55%10600.0NAD-specific glutamate dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D42284g PE=3 SV=1
A0A167ELA5_9ASCO73.07%10100.0NAD-specific glutamate dehydrogenase OS=Sugiyamaella lignohabitans GN=GDH2 PE=3 SV=1
Q6C6H1_YARLI70.63%10080.0NAD-specific glutamate dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E09603g PE=3 SV=1
A0A1E4TJM2_9ASCO65.41%10350.0NAD-specific glutamate dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_80654 PE=3 SV=1
UniRef50_F9XDF562.58%10450.0NAD-specific glutamate dehydrogenase n=127 Tax=Opisthokonta TaxID=33154 RepID=F9XDF5_ZYMTI
A0A1E3PL12_9ASCO61.02%10210.0NAD-specific glutamate dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82984 PE=3 SV=1
A0A1D8PI00_CANAL56.59%10390.0NAD-specific glutamate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GDH2 PE=3 SV=1
DHE2_YEAST43.94%10900.0NAD-specific glutamate dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GDH2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6327
Predicted cleavage: 44

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 1000 1068

Detailed signature matches

  1. Family IPR016210
    NAD-dependent glutamate dehydrogenase, eukaryotes
    1. PIRSF000184 (GDH_NAD)
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR006096
    Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
    1. PF00208 (ELFV_dehydrog)
    2. SM00839 (ELFV_dehyd...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. G3DSA:3.40.50...
  4. SSF53223 (Aminoacid...)
  5. mobidb-lite (disord...)

Protein sequence

>MCA_02515_1
MASSILPHPLLHKSSPSTMHQDLLTVPGRAPSSRVLKDSTSGYKSTPFEGKEAQLDAVMDEIDRQGFIPESLIENETRWF
YDHLGIDDMYFANESVENIVGHIHSLYAAKVAAYARDDKKLDIRLDKESDDHAVYIGSSAPGISNLAGPGYELRIDNKYL
NTSSPEKAYRVETFRAISSPETPEPDGTKRPDDLDPQHMRCYFVYKCKFAEDPATIRPDETDLKKISDVAFYEKASDNTK
AIYQNIISQVVKRTGPVIELYEIDGTKQRRIIIGYRQKTAPGYFSALSHLYHYYGLQSTRKYVEQFSNGVTIISLYLAPA
VRQTASTLEELEQLKKYPPIEHSIHQVTKEASLLYCLPQNHFRRLFAQGQLSLQESIYAHSAFIFVTHFLNRLGNEYSSL
VQILDVNKNTAHMEILENLKRRLRQETFTRAYINELMESQVDLIRQLYLQFANVHYVQSRGEGKNFLPTLSYQRLQTAKV
YNKKELKELIRRECTNEHQIMVFEAIMSFNDHVLKTNFYTPTKVALSFRLAPDFLPSSEYPQPLYGMFLVVGQEFRGFHL
RFRDVSRGGIRIVKSRNAEAYSINVRSLFDENYNLANTQQRKNKDIPEGGSKGVILLDFAHQDKGQQAFEKYIDSLCDLL
LPGNTPGIKEPVVDLLGHKEILFMGPDENTAGLVDWATLHAKKRGAPWWKSFFTGKSPSLGGIPHDKYGMTSLSVREYVK
GIYRKLDLDESKVTKMQTGGPDGDLGSNEILLSNEKYISIVDGSGVLCDPNGLDRDELLSLAKSRSLISEYDVSKLSKDG
YRVLVDDKDVTLPSGEVVANGTTFRNLYHLRAKERVDIFVPCGGRPEAINVNNVDKLISDEKKTLIPYIVEGANLFITQG
AKLRLEKAGAIVFKDASTNKGGVTSSSLEVLASLAFDDAGFFEHMCVDRDGNVPQFYKEYVKEVQETIKRNAQLEFEALW
REAELTRKPKSVLSDELSYAINDLTEELSASSLWDDEAFRNAILSEALPKKLQEAIGLEVILARVPSNYLRAIFGSYLAG
RFIYERGPNPGQFAFFEYMVEKRKKLAI

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process
GO:0019551 glutamate catabolic process to 2-oxoglutarate
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.