Protein
MCA_02504_1
Length
689 amino acids
Gene name: KNS1
Description: Dual specificity protein kinase Kns1; in S. cerevisiae involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis.
Browser: contigB:1495454-1497524+
RNA-seq: read pairs 241, FPKM 4.3, percentile rank 16.3% (100% = highest expression)
Protein function
| Annotation: | KNS1 | Dual specificity protein kinase Kns1; in S. cerevisiae involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis. | |
|---|---|---|---|
| KEGG: | K08287 | E2.7.12.1 | dual-specificity kinase [EC:2.7.12.1] |
| EGGNOG: | 0PFTM | KNS1 | protein kinase (Lkh1) |
| SGD closest match: | S000003942 | KNS1 | Dual specificity protein kinase KNS1 |
| CGD closest match: | CAL0000194707 | KNS1 | Serine/threonine protein kinase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9XIU2_GEOCN | 52.27% | 419 | 3e-143 | Similar to Saccharomyces cerevisiae YLL019C KNS1 Protein kinase involved in negative regulation of PolIII transcription OS=Geotrichum candidum GN=BN980_GECA17s01649g PE=4 SV=1 |
| UniRef50_A0A0J9XIU2 | 52.27% | 419 | 6e-140 | Similar to Saccharomyces cerevisiae YLL019C KNS1 Protein kinase involved in negative regulation of PolIII transcription n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIU2_GEOCN |
| MIA_01995_1 | 50.57% | 437 | 2e-141 | MIA_01995_1 |
| A0A167DKI0_9ASCO | 50.47% | 426 | 1e-138 | Serine/threonine protein kinase KNS1 OS=Sugiyamaella lignohabitans GN=KNS1 PE=4 SV=1 |
| A0A060T2Y8_BLAAD | 51.29% | 427 | 6e-137 | ARAD1C36674p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36674g PE=4 SV=1 |
| Q6CD14_YARLI | 47.56% | 431 | 1e-126 | YALI0C04587p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C04587g PE=4 SV=1 |
| A0A1E3PM63_9ASCO | 48.81% | 420 | 5e-125 | Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45968 PE=4 SV=1 |
| A0A1E4TK65_9ASCO | 49.14% | 405 | 2e-123 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_23714 PE=3 SV=1 |
| Q5AL00_CANAL | 43.90% | 451 | 2e-108 | Serine/threonine protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KNS1 PE=4 SV=1 |
| KNS1_YEAST | 40.13% | 456 | 2e-104 | Dual specificity protein kinase KNS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KNS1 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0122
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
100
200
300
400
500
600
689
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
cd14134 (PKc_CLK)
-
mobidb-lite (disord...)
Residue annotation
-
ATP binding site c...
-
active site cd14134
-
polypeptide substr...
-
activation loop (A...
Protein sequence
>MCA_02504_1 MSTSQLLDPSYSSYSIHSIHSSNVHGHKHPHDYHSSQSSDFYRNGQPAEVIVISDDEDEIRIEAGDSTTTWAASELPLGQ EYVHRSTNHNLQTSLSLSTDQQISLAHQGISNNSTTTNNNNNNNVDEDDDEVIVVGQVPASSSLTNTSSSSALASPSSLS SAATSVSSELPSLNLKRKSNRLDSPSHYNSHFPIIEENGPPTPHASSNASPNSTQSELEYSRLGGINNDNNNNNSSLKNS SSKKKRKLSYFNYIPIKGPIIKSSDVAVKTITDKGAYELPPLQDDKDGHLVLREPITAIANGRFIIRNELGQGTFGKVVS AYDKINQRYCAIKIIRAIPKYREASRTELRVLSTIQKYDKSNIYKCIHLQECFNYRNHICIVTDLLAISVYDFLKSNKYM AFPASHIQSFARQLLTSVCFLHDLDIIHTDLKPENIMLKDAKSFSYYDPGKKPHEFKSAEEAAQAKKDPSNYRKVLKNTS INLIDFGSAVFSDEFHNHVVSTRHYRAPEIILGIGWSHPCDIWSVGCILVELCTGEALFHTHDNSEHLALMQKAVGRDID RAILQRASKNSIGAELVCRTRNNRKNSVGDDGSTASINKTGQIRVHYPRTNTTSNSIKQVEAMHDLKTIIYGCLPSLTEK SESFWSQFLNLLYQIFQFDPKKRITARKALEHPWLRHPVDDEGSEYVSW
GO term prediction
Biological Process
GO:0006468 protein phosphorylation
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Cellular Component
None predicted.