MCA_02433_1

Protein

Length

630 amino acids

RNA-seq: read pairs 4649, FPKM 91.0, percentile rank 77.2% (100% = highest expression)

Protein function

EGGNOG:	0PFTW	PGUG_02361	transporter
SGD closest match:	S000003370	TPO2	Polyamine transporter 2
CGD closest match:	CAL0000176249	TPO3	Spermine transporter

Protein alignments

	%id	Aln length
MIA_02836_1	75.08%	630	MIA_02836_1
A0A0J9X777_GEOCN	69.44%	589	Similar to Saccharomyces cerevisiae YGR138C TPO2 Polyamine transport protein specific for spermine OS=Geotrichum candidum GN=BN980_GECA04s03926g PE=4 SV=1
A0A167FTU2_9ASCO	62.09%	575	Tpo2p OS=Sugiyamaella lignohabitans GN=TPO2 PE=4 SV=1
A0A1E3PK73_9ASCO	60.13%	597	Putative MFS multidrug transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_23917 PE=4 SV=1
A0A060TD96_BLAAD	64.29%	560	ARAD1D46156p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D46156g PE=4 SV=1
UniRef50_A0A1V6YQW3	62.25%	543	Uncharacterized protein n=1 Tax=Penicillium nalgiovense TaxID=60175 RepID=A0A1V6YQW3_PENNA
Q6CDU4_YARLI	57.07%	580	YALI0B21142p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B21142g PE=4 SV=1
A0A1E4TA75_9ASCO	55.81%	611	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32207 PE=4 SV=1
TPO2_YEAST	54.12%	595	Polyamine transporter 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO2 PE=1 SV=1
A0A1D8PEG8_CANAL	51.63%	614	Spermine transporter OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TPO3 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0118

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
178 - 630
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 630

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  198 - 577
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  194 - 630
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  178 - 618
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  195 - 611
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1 - 191

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

482 - 500

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

619 - 630

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

378 - 427

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

550 - 568

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

308 - 318

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

249 - 259

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

178 - 401

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

413 - 625

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

211 - 229

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

280 - 284

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

520 - 524

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

450 - 460

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

341 - 351

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

588 - 598

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

598 - 620

TMHMM
TMhelix (TMhelix)

284 - 306

TMHMM
TMhelix (TMhelix)

569 - 588

TMHMM
TMhelix (TMhelix)

258 - 280

TMHMM
TMhelix (TMhelix)

501 - 523

TMHMM
TMhelix (TMhelix)

229 - 251

TMHMM
TMhelix (TMhelix)

192 - 214

TMHMM
TMhelix (TMhelix)

527 - 549

TMHMM
TMhelix (TMhelix)

428 - 450

TMHMM
TMhelix (TMhelix)

460 - 482

TMHMM
TMhelix (TMhelix)

355 - 377

TMHMM
TMhelix (TMhelix)

318 - 340

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

461 - 481

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

260 - 279

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

285 - 307

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

569 - 587

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

428 - 449

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

525 - 549

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

501 - 519

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

599 - 618

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

192 - 210

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

319 - 340

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

230 - 248

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

352 - 377

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

138 - 163

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 53

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

209S

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

212P

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

213T

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

214G

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

216L

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

217N

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

234V

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

237M

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

238V

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

241F

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

245P

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

246L

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

248W

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

249S

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

295S

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

296S

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

299L

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

300S

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

303G

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

304G

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

307A

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

319I

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

320A

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

323A

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

324A

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

330P

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

436Y

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

439L

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

440Y

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

443F

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

444F

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

447P

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

461I

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

465F

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

469L

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

472A

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

476L

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

539G

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

542M

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

543V

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

546Y

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

550N

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

551N

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

554I

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

564A

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

565L

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

568K

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

569V

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

572R

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

573S

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

576G

putative substrate translocation pore
209S, 212P, 213T, 214G, 216L, 217N, 234V, 237M, 238V, 241F, 245P, 246L, 248W, 249S, 295S, 296S, 299L, 300S, 303G, 304G, 307A, 319I, 320A, 323A, 324A, 330P, 436Y, 439L, 440Y, 443F, 444F, 447P, 461I, 465F, 469L, 472A, 476L, 539G, 542M, 543V, 546Y, 550N, 551N, 554I, 564A, 565L, 568K, 569V, 572R, 573S, 576G
CDD
cd06174 (MFS)

Protein sequence

>MCA_02433_1
MSSNNNNNNNNDIVEEPKPFGGDLEAQRTNSTTGSFSSGEFPQRVTTNNDANFGKTLTKSETAASLQELGLSRTRVIDPN
YPEVRADVVPEFPEEYTIETQTGLVPVASLRQVRSGGSIGPTLTKRRTRMTPYLVPHDEEEEHQNEQQLQEPASAAEKES
LKKTRTSDEVEFVTFLFNDPENPQNWSKTYKWIVTLIASFLVLAVAYGSAAPTGGLNLIMEKFNVSLEVANLTVAIMVLG
FAVGPLIWSPLSEQIGRRPVYIISMSLYTIFNIPCALAPNIGCLLACRFLCGVFSSSGLSLAGGSIADVWKTEERGYAIA
YFAAAPYCGPVFGPIVSGWINIGSGRYSLLFWVNFALAGFAGLLMASIPETYAPVILKRRARKLRKETGNPNIMTEQEAL
KLNFKQLLETVLIRPISMMLTEPVLDLMNLYIVLIYSLLYGFFFCFPVIFSELHGYNDGIIGLMFIPILIGALFALFTTP
ILEKQYTKICQRREPTAEDRLIGAMIGAPFIPIALYILGATSYKHIIWVGPASSGLPFGYGMVLCYYSVNNYIIDCYTAY
AASALAAKVFMRSGGGAAFCLFTGIMYSSKRPGLQGSSYLLAGLATLMVLIPFGFYKYGAAIRAKLTRAK

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features