Protein

MCA_02428_1

Length
426 amino acids

Gene name: BIO2

Description: Biotin synthase, mitochondrial

Browser: contigB:1266927-1268208-

RNA-seq: read pairs 68, FPKM 2.0, percentile rank 11.7% (100% = highest expression)

Protein function

Annotation:BIO2Biotin synthase, mitochondrial
KEGG:K01012bioB biotin synthase [EC:2.8.1.6]
EGGNOG:0PGZCBIO2biotin synthase
SGD closest match:S000003518BIO2Biotin synthase, mitochondrial
CGD closest match:CAL0000188798BIO2Biotin synthase

Protein alignments

%idAln lengthE-value
MIA_05893_174.58%3580.0MIA_05893_1
A0A167FDA1_9ASCO71.06%3499e-175Biotin synthase OS=Sugiyamaella lignohabitans GN=BIO2 PE=3 SV=1
A0A0J9X5M9_GEOCN71.39%3537e-175Similar to Saccharomyces cerevisiae YGR286C BIO2 Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway OS=Geotrichum candidum GN=BN980_GECA03s02991g PE=3 SV=1
A0A060T3W8_BLAAD67.61%3554e-163ARAD1C43494p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C43494g PE=3 SV=1
A0A1E3PN82_9ASCO63.44%3722e-159Biotin synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46211 PE=3 SV=1
BIOB_YEAST65.14%3505e-159Biotin synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BIO2 PE=1 SV=2
UniRef50_P3245165.14%3501e-155Biotin synthase, mitochondrial n=315 Tax=cellular organisms TaxID=131567 RepID=BIOB_YEAST
Q6C903_YARLI64.04%3422e-150YALI0D15400p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D15400g PE=3 SV=1
A0A1D8PS33_CANAL58.96%3463e-138Biotin synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BIO2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9856
Predicted cleavage: 27

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 426

Detailed signature matches

  1. Family IPR002684
    Biotin synthase/Biotin biosynthesis bifunctional protein BioAB
    1. TIGR00433
    2. MF_01694 (BioB)
    3. SFLDG01278 (biotin_...)
  2. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  3. Domain IPR007197
    Radical SAM
    1. PF04055 (Radical_SAM)
  4. Domain IPR006638
    Elongator protein 3/MiaB/NifB
    1. SM00729 (MiaB)
  5. Domain IPR010722
    Biotin and thiamin synthesis-associated domain
    1. SM00876 (BATS_2)
    2. PF06968 (BATS)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SFLDG01060 (BATS_do...)
  2. SSF102114 (Radical ...)
  3. cd01335 (Radical_SAM)
  4. mobidb-lite (disord...)

Residue annotation

  1. SFLDG01060
  2. SFLDG01278
  3. FeS/SAM binding si...

Protein sequence

>MCA_02428_1
MFPLRIRSASLQLSRSLATLSPSPRSSPSYPPALKKALETDTPLHDWTKPEIESIYHMPLLSLIHHASIIHHKFHDPSEV
QLCTLMNIKTGGCSEDCKYCAQSSRYDTGLKAEKIVTVEQVYEQALKAKENGSTRFCMGAAWRDMRGRKSNLKRIAQMVE
KVNSLGLESCVTLGMVENEDQVEVLKNAGLTAYNHNVDTSREFYPKVISTRSYDDRLKTIATVRKGGVKVCSGGILGLGE
STSDHIGFLHTLSTMEEHPESVPINRLVPIKGTPLGNLLEEEFGTEEDDGNNNSTGEKKKKKKSIKLPFDAILRTAATAR
LLMPSSVIRLAAGRYTMKETDQAMCFLAGVNAIFTGEKMLTTMCNGWDEDKAMLERWGLKPMKSFERTIVDPSKEKNEKI
TTNAKEESTNIENNFSNRISFETISK

GO term prediction

Biological Process

GO:0009102 biotin biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004076 biotin synthase activity
GO:0051536 iron-sulfur cluster binding

Cellular Component

None predicted.