Protein

MCA_02371_1

Length
399 amino acids

Gene name: PDB1A

Description: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Browser: contigB:1088412-1090036+

RNA-seq: read pairs 32879, FPKM 1015.6, percentile rank 96.6% (100% = highest expression)

Protein function

Annotation:PDB1APyruvate dehydrogenase E1 component subunit beta, mitochondrial
KEGG:K00162PDHB pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
EGGNOG:0PGHCPDB1pyruvate dehydrogenase e1 component
SGD closest match:S000000425PDB1Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
CGD closest match:CAL0000175775PDB1Pyruvate dehydrogenase (Acetyl-transferring) subunit E1 beta

Protein alignments

%idAln lengthE-value
MIA_01841_188.89%3690.0MIA_01841_1
A0A0J9XI00_GEOCN78.45%3990.0Similar to Saccharomyces cerevisiae YBR221C PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex OS=Geotrichum candidum GN=BN980_GECA18s01594g PE=4 SV=1
A0A060TGC3_BLAAD79.25%3710.0ARAD1D28886p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D28886g PE=4 SV=1
A0A1E3PRA1_9ASCO85.11%3290.0Thiamin diphosphate-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44559 PE=4 SV=1
A0A1E4TH92_9ASCO82.35%3400.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26414 PE=4 SV=1
A0A167E1C1_9ASCO85.17%3170.0Pyruvate dehydrogenase (Acetyl-transferring) subunit E1 beta OS=Sugiyamaella lignohabitans GN=PDB1 PE=4 SV=1
Q6C4G4_YARLI80.55%3290.0YALI0E27005p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E27005g PE=4 SV=1
Q5A5V6_CANAL70.86%3500.0Pyruvate dehydrogenase (Acetyl-transferring) subunit E1 beta OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDB1 PE=4 SV=1
ODPB_YEAST73.72%3310.0Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDB1 PE=1 SV=2
UniRef50_P3247373.72%3310.0Pyruvate dehydrogenase E1 component subunit beta, mitochondrial n=279 Tax=cellular organisms TaxID=131567 RepID=ODPB_YEAST

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9886
Predicted cleavage: 60

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 399

Detailed signature matches

  1. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  2. Domain IPR005475
    Transketolase-like, pyrimidine-binding domain
    1. PF02779 (Transket_pyr)
    2. SM00861 (Transket_p...)
  3. Domain IPR009014
    Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
    1. G3DSA:3.40.50...
    2. SSF52922 (TK C-term...)
  4. Domain IPR033248
    Transketolase, C-terminal domain
    1. PF02780 (Transketol...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. cd07036 (TPP_PYR_E1...)

Residue annotation

  1. alpha subunit inte...
  2. TPP binding site c...
  3. heterodimer interf...

Protein sequence

>MCA_02371_1
MKLTNSACSSVKRLASSAVASLNSSKTSSQRILTPKSSTIITPSIGFQAAIRTYDFNRSASTAGGPKTMTVRDALNSAMA
EEMDLDDNVFLMGEEVGQYNGAYKVSRGLLDRFGERRVIDTPITEMGFTGLCVGAALAGLKPICEFMTFNFAMQAIDQII
NSGAKTYYMSGGTQQCSVTFRGPNGAAAGVAAQHSQDYSSWYGQIPGLKVVSPYSAEDCRGLLKASIRDPNVTIFLENEI
LYGESFPISEEALSPDFVLPFGQAKIERPGKDVTIVAHSRNVEFSLKAAEILKKDYDVEAEVINLRTIKPLDMPTIIKSV
KKTNRMVSVEAGFPAFGVGSELCAQIMESDAFDYLDAPVMRVTGAEVPTPYAIELENFAFPTPEIIVKGAKSVLYIDSE

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.