Protein

MCA_02328_1

Length
399 amino acids

Gene name: HRR25

Description: Casein kinase I homolog HRR25; in S. cerevisiae esicular traffic, DNA repair, the CVT pathway, monopolar attachment of sister kinetochores at meiosis I, and ribosomal subunit biogenesis.

Browser: contigB:954725-955925+

RNA-seq: read pairs 2409, FPKM 74.4, percentile rank 73.8% (100% = highest expression)

Protein function

Annotation:HRR25Casein kinase I homolog HRR25; in S. cerevisiae esicular traffic, DNA repair, the CVT pathway, monopolar attachment of sister kinetochores at meiosis I, and ribosomal subunit biogenesis.
KEGG:K14758HRR25 casein kinase I homolog HRR25 [EC:2.7.11.1]
EGGNOG:0PFS3HRR25Casein kinase I
SGD closest match:S000006125HRR25Casein kinase I homolog HRR25
CGD closest match:CAL0000187651HRR25Serine/threonine protein kinase

Protein alignments

%idAln lengthE-value
MIA_01137_182.08%3180.0MIA_01137_1
UniRef50_Q4WIA575.55%3190.0Casein kinase I, putative n=8 Tax=Eukaryota TaxID=2759 RepID=Q4WIA5_ASPFU
A0A0J9X4Q4_GEOCN83.50%2970.0Similar to Saccharomyces cerevisiae YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking OS=Geotrichum candidum GN=BN980_GECA02s05576g PE=3 SV=1
A0A060TAH5_BLAAD82.65%2940.0ARAD1D24046p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D24046g PE=3 SV=1
Q59S64_CANAL77.35%3090.0Serine/threonine protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HRR25 PE=3 SV=1
Q6C2F7_YARLI68.92%3252e-176YALI0F08305p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F08305g PE=4 SV=1
A0A1E4TDR6_9ASCO75.08%3172e-178Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19333 PE=3 SV=1
A0A1E3PFX9_9ASCO76.01%2961e-176Kinase-like protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_26966 PE=4 SV=1
HRR25_YEAST67.87%3054e-160Casein kinase I homolog HRR25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRR25 PE=1 SV=1
A0A167CKX9_9ASCO52.08%2882e-102Serine/threonine protein kinase YCK2 OS=Sugiyamaella lignohabitans GN=YCK2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5685
Predicted cleavage: 26

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 399

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. SM00220 (serkin_6)
    3. PF00069 (Pkinase)
  3. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  4. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. cd14125 (STKc_CK1_d...)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd14125
  3. polypeptide substr...
  4. activation loop (A...

Protein sequence

>MCA_02328_1
MSAVDLRVGKKYRLGRKIGSGSFGDIYVGKNIISGEEVAVKLESIRARHPQLEYESKVYKALVGGIGIPFVRWYGTECDY
NALVIDLLGPSLEDLFNFCDRKFSYKTILLLADQLVCRLEFIHAKSFIHRDIKPDNFLMGLNRRGNQVNVIDFGLAKKFR
DPRTHIHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLAYMLVYFCKGSLPWQGLKAATKKQKYDRIMEKKISTPS
DVLTRGLPYEFYIFLNYTRSLRFDNKPDYVFLRKLVRDLFTRSNYYYDYCFDWTLIKYKRQGKLKDADAQNQEDNNEDGT
KNNTNVANTNNATISNSNNPHDANTVKNENGKQIAYGYQQEYYNPSKPYDDGPSAVNKAAYESAMNANKPKDEMELNMR

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.