Protein

MCA_02251_1

Length
201 amino acids

Gene name: SEC4

Description: Ras-related protein SEC4

Browser: contigB:717139-718338+

RNA-seq: read pairs 6622, FPKM 405.1, percentile rank 93.6% (100% = highest expression)

Protein function

Annotation:SEC4Ras-related protein SEC4
KEGG:K07901RAB8A Ras-related protein Rab-8A
EGGNOG:0PFGWSEC4(GTP)-binding protein
SGD closest match:S000001889SEC4Ras-related protein SEC4
CGD closest match:CAL0000186445SEC4Ras-related protein SEC4

Protein alignments

%idAln lengthE-value
MIA_04028_185.29%2043e-123MIA_04028_1
A0A0J9X6L2_GEOCN81.95%2059e-119Similar to Saccharomyces cerevisiae YFL005W SEC4 Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy OS=Geotrichum candidum GN=BN980_GECA03s07303g PE=4 SV=1
A0A060T2A8_BLAAD83.42%1991e-117ARAD1C27434p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C27434g PE=4 SV=1
A0A167EGI1_9ASCO86.74%1811e-114Rab family GTPase SEC4 OS=Sugiyamaella lignohabitans GN=SEC4 PE=4 SV=1
RYL1_YARLI70.50%2008e-102Ras-like GTP-binding protein RYL1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RYL1 PE=3 SV=1
UniRef50_G1X32469.95%2032e-95Uncharacterized protein n=24 Tax=Eukaryota TaxID=2759 RepID=G1X324_ARTOA
A0A1E4TJV5_9ASCO63.29%2071e-91Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_63438 PE=4 SV=1
SEC4_YEAST67.82%1742e-87Ras-related protein SEC4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC4 PE=1 SV=1
SEC4_CANAL65.12%1721e-83Ras-related protein SEC4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SEC4 PE=3 SV=1
A0A1E3PED3_9ASCO62.57%1872e-83Ras-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47942 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0808

Protein family membership

Domains and repeats

  1. Domain
1 20 40 60 80 100 120 140 160 180 201

Detailed signature matches

  1. Family IPR001806
    Small GTPase superfamily
    1. PF00071 (Ras)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR005225
    Small GTP-binding protein domain
    1. TIGR00231
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.70...
  2. G3DSA:3.40.50...
  3. PR00449 (RASTRNSFRMNG)
  4. PS51419 (RAB)
  5. SM00173 (ras_sub_4)
  6. SM00174 (rho_sub_3)
  7. SM00175 (rab_sub_5)
  8. SM00176 (ran_sub_2)
  9. cd01867 (Rab8_Rab10...)
  10. mobidb-lite (disord...)

Residue annotation

  1. Rab subfamily moti...
  2. G1 box cd01867
  3. GTP/Mg2+ binding s...
  4. Rab subfamily moti...
  5. Switch I region cd...
  6. GEF interaction si...
  7. G2 box cd01867
  8. Rab family motif 1...
  9. putative GDI inter...
  10. putative effector ...
  11. Rab family motif 2...
  12. G3 box cd01867
  13. Switch II region c...
  14. Rab family motif 3...
  15. Rab family motif 4...
  16. Rab family motif 5...
  17. Rab subfamily moti...
  18. G4 box cd01867
  19. G5 box cd01867
  20. Rab subfamily moti...

Protein sequence

>MCA_02251_1
MSTTRTYDLLVKLLLIGDSGVGKSCLLLRFCDDQFTPSFITTIGIDFKIRTIDLDGKKVKLQVWDTAGQERFKTITTAYY
RGAMGILLVYDVTDEKSFHNIRSWFANVQQHASENVVLVLVGNKSDMEDKRVISTEQGQALADELGIPFIEASAKTKHNV
EETFFSLARRVKENVTSSAGDNDHSGSVNVNSSNSSNSKCC

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component

None predicted.