Protein
MCA_02246_1
Length
321 amino acids
Gene name: SKP1C
Description: Suppressor of kinetochore protein 1
Browser: contigB:703503-704469+
RNA-seq: read pairs 48, FPKM 1.8, percentile rank 11.4% (100% = highest expression)
Protein function
| Annotation: | SKP1C | Suppressor of kinetochore protein 1 | |
|---|---|---|---|
| KEGG: | K03094 | SKP1 | S-phase kinase-associated protein 1 |
| EGGNOG: | 0PN0Q | SCONC | Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor (By similarity) |
| SGD closest match: | S000002736 | SKP1 | Suppressor of kinetochore protein 1 |
| CGD closest match: | CAL0000178736 | SKP1 | SCF ubiquitin ligase subunit |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04999_1 | 42.53% | 174 | 2e-32 | MIA_04999_1 |
| A0A0J9X9G2_GEOCN | 38.46% | 169 | 1e-32 | Similar to Saccharomyces cerevisiae YDR328C SKP1 Evolutionarily conserved kinetochore protein OS=Geotrichum candidum GN=BN980_GECA06s04696g PE=3 SV=1 |
| A0A1E3PDZ5_9ASCO | 37.87% | 169 | 1e-30 | E3 ubiquitin ligase SCF complex, Skp subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47850 PE=3 SV=1 |
| UniRef50_Q9Y709 | 35.50% | 169 | 4e-27 | Suppressor of kinetochore protein 1 n=131 Tax=Eukaryota TaxID=2759 RepID=SKP1_SCHPO |
| Q6CHA1_YARLI | 36.09% | 169 | 5e-28 | YALI0A10879p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A10879g PE=3 SV=1 |
| A0A1E4TAM3_9ASCO | 34.32% | 169 | 6e-28 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_128786 PE=3 SV=1 |
| A0A060T3R6_BLAAD | 36.72% | 177 | 7e-24 | ARAD1C39182p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C39182g PE=3 SV=1 |
| Q59WE2_CANAL | 36.09% | 169 | 2e-23 | SCF ubiquitin ligase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SKP1 PE=3 SV=1 |
| SKP1_YEAST | 28.93% | 197 | 1e-18 | Suppressor of kinetochore protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKP1 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0522
Protein family membership
- S-phase kinase-associated protein 1-like (IPR001232)
Domains and repeats
-
Domain
1
50
100
150
200
250
321
Detailed signature matches
no IPR
Unintegrated signatures
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_02246_1 MAANKKNKSKNKSNKKSSAEKSSKKDSSSKEDIAEVSTSVPDTSSSLSPTKTATSALTTTIRTLLTGSSEKDKDKGKGKA DASTANGDSNNKTTEASNCINKTKTIGASIEKGNTITSTKANHKNSNTKEASPFIYQDDLTAGEEYVTFVSSDQKKFKVP LAAAEKSGLVKNFLQDFGDLQEKAETPMEIPFPNIDAGTLGRVITYLKYHKNETEVFDRTKWNTQRPADVDMYSTINRTT DIIQWDYDFIAELNQEQFLSMFKAANYMEIDFLLHLCCQMLANVVRGKSAQEIRDIFNIPNTFTEEQKREIHCENNLLPY P
GO term prediction
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
Molecular Function
None predicted.
Cellular Component
None predicted.