Protein

MCA_02236_1

Length
995 amino acids


Gene name: HUL4

Description: Probable E3 ubiquitin-protein ligase HUL4

Browser: contigB:672872-676094-

RNA-seq: read pairs 1239, FPKM 15.4, percentile rank 34.7% (100% = highest expression)

Protein function

Annotation:HUL4Probable E3 ubiquitin-protein ligase HUL4
KEGG:K12232HECTD2 E3 ubiquitin-protein ligase HECTD2 [EC:2.3.2.26]
EGGNOG:0PH0XHUL4Ubiquitin-protein ligase
SGD closest match:S000003797HUL4Probable E3 ubiquitin-protein ligase HUL4
CGD closest match:CAL0000198465orf19.5892Putative E3 ubiquitin-protein ligase

Protein alignments

%idAln lengthE-value
MIA_03857_153.92%9810.0MIA_03857_1
A0A0J9X7X5_GEOCN44.97%8940.0Similar to Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases OS=Geotrichum candidum GN=BN980_GECA04s06511g PE=4 SV=1
UniRef50_A0A0J9X7X544.97%8940.0Similar to Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X7X5_GEOCN
A0A060SZV9_BLAAD54.66%5470.0ARAD1C07260p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C07260g PE=4 SV=1
A0A167DCT0_9ASCO55.79%5180.0Putative E3 ubiquitin-protein ligase HUL4 OS=Sugiyamaella lignohabitans GN=HUL4 PE=4 SV=1
A0A1E3PR22_9ASCO46.42%5459e-156Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_39297 PE=4 SV=1
Q6C901_YARLI45.67%5082e-141YALI0D15444p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D15444g PE=4 SV=1
Q5ANK9_CANAL39.62%5252e-121Putative E3 ubiquitin-protein ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5892 PE=4 SV=1
A0A1E4TEB0_9ASCO38.34%5065e-109Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31155 PE=4 SV=1
HUL4_YEAST37.50%5285e-102Probable E3 ubiquitin-protein ligase HUL4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HUL4 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5944
Predicted cleavage: 25

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 995

Detailed signature matches

    1. PF00632 (HECT)
    2. cd00078 (HECTc)
    3. SSF56204 (Hect, E3 ...)
    4. SM00119 (hect_3)
    5. PS50237 (HECT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. TRANSMEMBRANE (Tran...)
  2. mobidb-lite (disord...)

Residue annotation

  1. catalytic cleft cd...
  2. E2 interaction sit...

Protein sequence

>MCA_02236_1
MSSWALFSSKKPSTNLYSSYHQRVPSADNRHQQEVAQSLLLNVSTHSSTNEIVKTVSAVNALNSSPTRPASQKTNSQIVL
KYKCICCGTHLKVPGGLPYFKCSICDTFYDSKIPPLLKDESVWPPFSLKLIEKAIKDDLELIDSKSKTAYKAETALPSYE
NDEHYPNLEKVIKLLFSSVNFLNKAFSLGLTKLSYSRPNIDFEDVATFYTLIDSLKSKRILITLLEATLSLLKRPRHKLD
SPSDIFFLLIILENPIFVTHSIFSSINRYCENKAKSRFLSKQIHRNKNSDDIPSESIEGGSSYNHKCRHYYNRSECTPPN
VDIDSKTRSIAVEILERTVSILSNTPKKTRHYLLNWISRYPASQFQSKTELLNAYISYRLTDIAQVVESPKKKQQDRIPS
IIDTLYHASTGLGTSQQNRNSNSLQKVSLAPGSPTVSDGMPPGTESLEYSNFSSSSSRNNENTLPRRSNNLTSRSLSPSG
KRKRPGSKTVPVYTYGKDWKIASFARLQSILFNANIITRKMPVSQFYNTMVDYVDIKADFEAWERLGVPVSTLNLQTKIP
AAHSTDNGSHQLAVATAALESGSSYEVPLFAFCEYPFFISMGTKTRILEHDARRQMAHKAHEAFFNSISTNTPQQLYLHV
SVRRSHILEDSFEVFESHEDDLKKGIRVHFIGEPGIDVGGLKKEWFLLLMRELFKPERGIFLCDEESGYSWFNIKAKQPL
KYYKLTGVALGLALYNSTILDTNFHSVIFRKLFGAPYTFDDLKDLKPSLGKGLQQLLDYEGDDLEEVFSLNFTVPKESET
GSVIGEENLIPNGCNISVTKKNRQDYVKRVIAYHLETSIRHVFEPLKQGFYKVVASNALTLFRPEEIELLIHGSDEEYFD
VDALRAVTRYNHWSPKYTTPDKDAPVVQWFWKYFKMMNFKDQRKLLMFVTGSDRIPATGIATMTFSITRAGGNSNRYPVS
HTCFNELCLYEYDSKQKLVNMLTRAIFESEGFGLK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

None predicted.