Protein
MCA_02050_1
Length
170 amino acids
Gene name: SKP1B
Description: Suppressor of kinetochore protein 1
Browser: contigB:102820-103333-
RNA-seq: read pairs 4267, FPKM 308.3, percentile rank 92.0% (100% = highest expression)
Protein function
| Annotation: | SKP1B | Suppressor of kinetochore protein 1 | |
|---|---|---|---|
| KEGG: | K03094 | SKP1 | S-phase kinase-associated protein 1 |
| EGGNOG: | 0PN0Q | SCONC | Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor (By similarity) |
| SGD closest match: | S000002736 | SKP1 | Suppressor of kinetochore protein 1 |
| CGD closest match: | CAL0000178736 | SKP1 | SCF ubiquitin ligase subunit |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04999_1 | 64.46% | 166 | 5e-69 | MIA_04999_1 |
| A0A0J9X9G2_GEOCN | 58.39% | 161 | 7e-63 | Similar to Saccharomyces cerevisiae YDR328C SKP1 Evolutionarily conserved kinetochore protein OS=Geotrichum candidum GN=BN980_GECA06s04696g PE=3 SV=1 |
| Q6CHA1_YARLI | 56.36% | 165 | 5e-62 | YALI0A10879p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A10879g PE=3 SV=1 |
| A0A1E3PDZ5_9ASCO | 56.29% | 167 | 1e-57 | E3 ubiquitin ligase SCF complex, Skp subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47850 PE=3 SV=1 |
| UniRef50_V5EED2 | 54.37% | 160 | 3e-53 | SCF ubiquitin ligase, Skp1 component n=10 Tax=Basidiomycota TaxID=5204 RepID=V5EED2_KALBG |
| A0A060T3R6_BLAAD | 56.97% | 165 | 3e-54 | ARAD1C39182p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C39182g PE=3 SV=1 |
| A0A1E4TAM3_9ASCO | 51.55% | 161 | 1e-53 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_128786 PE=3 SV=1 |
| Q59WE2_CANAL | 48.81% | 168 | 2e-45 | SCF ubiquitin ligase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SKP1 PE=3 SV=1 |
| SKP1_YEAST | 37.81% | 201 | 1e-40 | Suppressor of kinetochore protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKP1 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0125
Protein family membership
- S-phase kinase-associated protein 1-like (IPR001232)
- S-phase kinase-associated protein 1 (IPR016897)
Domains and repeats
-
Domain
1
20
40
60
80
100
120
140
160
170
Detailed signature matches
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SM00512 (skp1_3)
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-
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PIRSF028729 (SCF_Skp)
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-
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SSF54695 (POZ domain)
-
-
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PF03931 (Skp1_POZ)
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no IPR
Unintegrated signatures
Protein sequence
>MCA_02050_1 MSKVTLLCDNQRFEVDKKVACMSNLIKNMIEDLGGDSAEIPLSDMRASTLQKILEYCEHHKDDPIPEPEVNPDAIDDLEP SDRIKRSTDITEWDYNFINVEQPLLFEIMLKANFLDIKPLLDLTCKTVANMIKGKNPDELRATFNIKNDFTPEQLEEIRR ENEWEADPTP
GO term prediction
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
Molecular Function
None predicted.
Cellular Component
None predicted.