Protein

MCA_02016_1

Length
544 amino acids

Gene name: ICL1

Description: Isocitrate lyase

Browser: contigB:35049-36684-

RNA-seq: read pairs 17620, FPKM 399.5, percentile rank 93.5% (100% = highest expression)

Protein function

Annotation:ICL1Isocitrate lyase
KEGG:K01637E4.1.3.1 isocitrate lyase [EC:4.1.3.1]
EGGNOG:0PGNDICL1Isocitrate lyase
SGD closest match:S000000867ICL1Isocitrate lyase
CGD closest match:CAL0000178151ICL1Isocitrate lyase

Protein alignments

%idAln lengthE-value
MIA_05609_188.17%5410.0MIA_05609_1
A0A0J9XJ79_GEOCN84.69%5420.0Isocitrate lyase OS=Geotrichum candidum GN=BN980_GECA22s01407g PE=3 SV=1
A0A167ED90_9ASCO81.07%5440.0Isocitrate lyase OS=Sugiyamaella lignohabitans GN=ICL1 PE=3 SV=1
A0A1E3PKI0_9ASCO79.04%5440.0Isocitrate lyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_24711 PE=3 SV=1
UniRef50_Q6BRY474.72%5420.0Isocitrate lyase n=31 Tax=Eukaryota TaxID=2759 RepID=ACEA_DEBHA
Q59RB8_CANAL75.51%5430.0Isocitrate lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ICL1 PE=3 SV=1
ACEA_YARLI78.07%5380.0Isocitrate lyase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ICL1 PE=3 SV=3
A0A060T8S1_BLAAD72.36%5390.0Isocitrate lyase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D13486g PE=3 SV=1
A0A1E4TH85_9ASCO70.53%5430.0Isocitrate lyase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_25331 PE=3 SV=1
ACEA_YEAST66.17%5410.0Isocitrate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ICL1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3423

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 500 544

Detailed signature matches

  1. Family IPR006254
    Isocitrate lyase
    1. PIRSF001362 (ICL)
    2. PF00463 (ICL)
    3. TIGR01346
  2. Domain IPR015813
    Pyruvate/Phosphoenolpyruvate kinase-like domain
    1. SSF51621 (Phosphoen...)
  3. SITE IPR018523
    Isocitrate lyase/phosphorylmutase, conserved site
    1. PS00161 (ISOCITRATE...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.20.20.60

Protein sequence

>MCA_02016_1
MSIDLKAEQKAFDDEVRQIKEWWSQPRWSQTKRIYTAEEIAKKRGTIASSYRSSLQAKKLYKLLEEHWKKQSVSFTYGAL
DPVQVTQMAKFLDTVYVSGWQSSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQHEERMNMTPEERAKTPYI
DYLRPIIADADTGHGGLTAVVKLTKMFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPIQEHINRLVAIRASADIYNSDLL
AVARTDSEAATLITSTIDYRDHYFIVGSTNPDIPSLIEVTTAAEERGAQGEELQRIEDEWVAKAGLKLFHEAVIDEINAG
NYPNKQALIKEFTSKVGPLTCTSNKEARALAKKLTGKDIYFNWEAPRVREGYYRYQGGTQCAVNRARAYAPYCDLIWMES
KLPDYAQAKEFAEGVRAAYPNQWLAYNLSPSFNWTKAMSPSDQETYIQRLGKLGYVWQFITLAGLHTNALISHQFAKGYS
EIGMKAYGSFIQQPELDNGVDVVKHQKWSGAEYIDNILKMITGGVSSTAAMGAGVTEEQFKSKA

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0019752 carboxylic acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity

Cellular Component

None predicted.