Protein

MCA_01990_1

Length
864 amino acids

Gene name: MCM3

Description: DNA replication licensing factor MCM3; component of the Mcm2-7 hexameric helicase complex

Browser: contigA:6046194-6048789+

RNA-seq: read pairs 854, FPKM 12.2, percentile rank 29.5% (100% = highest expression)

Protein function

Annotation:MCM3DNA replication licensing factor MCM3; component of the Mcm2-7 hexameric helicase complex
KEGG:K02541MCM3 DNA replication licensing factor MCM3 [EC:3.6.4.12]
EGGNOG:0PFNCMCM3DNA replication licensing factor Mcm3
SGD closest match:S000000758MCM3DNA replication licensing factor MCM3
CGD closest match:CAL0000199452MCM3DNA helicase

Protein alignments

%idAln lengthE-value
MIA_06325_169.80%8710.0MIA_06325_1
A0A0J9X361_GEOCN64.59%8670.0DNA helicase OS=Geotrichum candidum GN=BN980_GECA01s09338g PE=3 SV=1
A0A167EJY7_9ASCO74.14%6690.0DNA helicase OS=Sugiyamaella lignohabitans GN=MCM3 PE=3 SV=1
A0A1E3PKT1_9ASCO60.32%8770.0DNA helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51295 PE=3 SV=1
A0A060TCY3_BLAAD69.53%6860.0DNA helicase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B19470g PE=3 SV=1
UniRef50_R1G7R556.73%8690.0DNA helicase n=7 Tax=Fungi TaxID=4751 RepID=R1G7R5_BOTPV
A0A1D8PHW4_CANAL65.97%6670.0DNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MCM3 PE=3 SV=1
A0A1E4TF51_9ASCO61.70%7180.0DNA helicase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_44057 PE=3 SV=1
Q6C0T3_YARLI52.44%8600.0DNA helicase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F21945g PE=3 SV=1
MCM3_YEAST63.23%6500.0DNA replication licensing factor MCM3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCM3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0076

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 864

Detailed signature matches

  1. Family IPR031327
    Mini-chromosome maintenance protein
    1. SM00350 (mcm)
  2. Family IPR008046
    DNA replication licensing factor Mcm3
    1. PR01659 (MCMPROTEIN3)
  3. Domain IPR027925
    MCM N-terminal domain
    1. PF14551 (MCM_N)
  4. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  5. Domain IPR033762
    MCM OB domain
    1. PF17207 (MCM_OB)
  6. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  7. Domain IPR001208
    MCM domain
    1. PS50051 (MCM_2)
    2. PF00493 (MCM)
    3. PR01657 (MCMFAMILY)
  8. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
  9. SITE IPR018525
    Mini-chromosome maintenance, conserved site
    1. PS00847 (MCM_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.8.300
  3. G3DSA:2.40.50...
  4. G3DSA:3.30.16...
  5. G3DSA:3.40.50...
  6. cd00009 (AAA)
  7. mobidb-lite (disord...)

Residue annotation

  1. Walker A motif cd0...
  2. ATP binding site c...
  3. Walker B motif cd0...
  4. arginine finger cd...

Protein sequence

>MCA_01990_1
MSEEPEFNPLQGSIASERQRIFQEFLEREDGPTNYHDEILVMLRKQKKRLIVSLDELRDFDKPFWSGLLNTPADFLPVID
KALQETVMVLRNPRLHQISESDIFSVALKGSFGDHLVNPRTIDAAHLGKLMCVEGIVTRCSLVRPKVVRSVHYAEATGQF
RTREYRDATTSFDPIPTTTVYPTEDENNNPLMTEYGYSTYKDYQTISIQEMPEKAPAGQLPRSIDIVLDDDLVDTTKPGD
RVQIVGVYRSLGSNIASLSSTFKSLIVANNIVLLSSKGGSQIETQKINDIDIRNINRISRKNDVFKLLSQSLAPSIYGHD
YIKKAILLMLLGGVEKNLPNGTHLRGDINILMVGDPSTAKSQMLRFVLNTANLAIATTGRGSSGVGLTAAVTTDSETGER
RLEAGAMVLADRGIVCIDEFDKMSDVDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVIAAANPIYGQYDTHKDPHQNIAL
PDSLLSRFDLLFVVTDNINRTRDWKISEHVLRMHRYLAPGSEEGAPARDANEQSLSVGDERNPGEERESQVFEKFNPLLH
GGLAETEEKVEDIEILSIPFIRKYIQYAKSRAPPILTEEANAYIVSTYSALRNDQLTGNQRHTSPITVRTLETLIRLSTA
HAKARLSSHVEEADVEVAEEILRFALFKEVSKKRSNKRQKTTHAEVTAEEDVIRRTQNINLGTRTTVSQNSQRSQPQGVE
STNESRGEGEEEETTAETSSLPSRLRLEPTEQNSTTLSQSSQQNDSQFSWPSSSGSVLESSQDPSIETSSAISKSRYNEF
LRLAGQVLNSPEFVEEAEIEKVRLLNAINSNIQDPFTDEESGAALQKMSDSNKIMVNDDLIYKI

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0006270 DNA replication initiation

Molecular Function

GO:0003677 DNA binding
GO:0005524 ATP binding

Cellular Component

GO:0042555 MCM complex