Protein

MCA_01989_1

Length
1,670 amino acids

Gene name: CHC1

Description: Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis

Browser: contigA:6040718-6045883+

RNA-seq: read pairs 16021, FPKM 118.5, percentile rank 81.7% (100% = highest expression)

Protein function

Annotation:CHC1Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis
KEGG:K04646CLTC clathrin heavy chain
EGGNOG:0PIM9FG05619.1clathrin heavy chain
SGD closest match:S000003174CHC1Clathrin heavy chain
CGD closest match:CAL0000192308CHC1Clathrin heavy chain (Fragment)

Protein alignments

%idAln lengthE-value
MIA_06326_188.50%15740.0MIA_06326_1
A0A0J9XG76_GEOCN80.61%16760.0Clathrin heavy chain OS=Geotrichum candidum GN=BN980_GECA13s00098g PE=3 SV=1
A0A060SZQ4_BLAAD75.19%16730.0Clathrin heavy chain OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C10142g PE=3 SV=1
A0A1E3PTQ6_9ASCO72.32%16580.0Clathrin heavy chain OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_20871 PE=3 SV=1
A0A167E0K0_9ASCO76.55%15610.0Clathrin heavy chain OS=Sugiyamaella lignohabitans GN=CHC1 PE=3 SV=1
A0A1E4TCI7_9ASCO66.73%16710.0Clathrin heavy chain OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32710 PE=3 SV=1
Q6CGR2_YARLI70.16%15820.0Clathrin heavy chain OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A17127g PE=3 SV=1
UniRef50_A0A1W5D1A664.16%16770.0Clathrin heavy chain n=1 Tax=Umbilicaria pustulata TaxID=136370 RepID=A0A1W5D1A6_9LECA
A0A1D8PPS9_CANAL62.66%16630.0Clathrin heavy chain (Fragment) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CHC1 PE=4 SV=1
CLH_YEAST59.36%16240.0Clathrin heavy chain OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CHC1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0156

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Repeat
1 200 400 600 800 1000 1200 1400 1670

Detailed signature matches

  1. Family IPR016341
    Clathrin, heavy chain
    1. PIRSF002290 (CHC)
  2. Domain IPR001473
    Clathrin, heavy chain, propeller, N-terminal
    1. SSF50989 (Clathrin ...)
  3. Domain IPR015348
    Clathrin, heavy chain, linker, core motif
    1. PF09268 (Clathrin-link)
  4. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  5. Domain IPR011990
    Tetratricopeptide-like helical domain
    1. G3DSA:1.25.40.10
  6. Domain IPR012331
    Clathrin, heavy chain, linker
    1. G3DSA:1.25.40.30
  7. Repeat IPR022365
    Clathrin, heavy chain, propeller repeat
    1. PF01394 (Clathrin_p...)
  8. Repeat IPR000547
    Clathrin, heavy chain/VPS, 7-fold repeat
    1. SM00299 (CLH_2)
    2. PS50236 (CHCR)
    3. PF00637 (Clathrin)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:2.130.1...
  3. PF13838 (Clathrin_H...)
  4. mobidb-lite (disord...)

Protein sequence

>MCA_01989_1
MAANELPIKFQEYLKLGDVEVPESAISFNTCTLESDKYICVRETSPAGNKVAIINLHDNNSVIRKSMSAESAIMNPSELI
IALRAQGGTLQVFNLETKQRLRSATLSETIVFWNWISNSTLGIVTESSIYHWNITTSENPTKLTSRHASLANCQIISYHA
NPDEKWSALVGIAQENGRVAGHIQLYSKERGISQGIEGHASSFAAIRLDGGASDTQLFAFANRTATGCKLHIVEIDHQEG
NPQYQKKAIDLYCPAELPNDFPVSVEVSNKYGIVYVITKYGLIHLYDLETGVCIFMNRISQDPIFTATKFEATSGVLAIN
RKGHVLSVSLNEETVIPYILNNLGNASLALALASRGGLPGADNLYQQQFNQLLNSGNFNEAAKIAANSPRGILRTQETVQ
KLKSIQAPPGQVYPILQYFSTLLDKGSLNKFESIELARPVLEQDRLPLLEKWMTENKLECSEELGDIVRARNLNLALSIY
LRANVPFKVVAAMAELGHYDKIVPYCQKVDYTPDYTSLLQSMVYSNPDKAAEFATQLVNQKVSGLDLERIVDIFLSQNHI
QQATAFLLDALKDNLPEQGHLQTRLLEMNLLKAPQVADAILGNDMFSHYDRTRVAKLAEQAGLFQRALEHYDDMKDIKRV
LAHSNVLNPEWLVSYFGKLTVDQTLEALREMLKTNIRQNLQIVIQVATKYSDLVGPLNLIKLFEEFKTPEGLFYYLQTIV
NLSDDPDVVFKYIQAAAQIGQFNEVERIVRENNVYNAEKVKNFLKEAKLDDQLPLVIVCDKYNFVHDLILYLYQNQLFKY
IEIYVQRVNPARTPEVIAALLDVDCEESVIKALLDSVPVDKIPIESLVLEVEKRNRLKILLPFLEKVLATGSQDHSLYDA
LAKIYIDSNNNPEKFLKENSNYDTLVVGKYCEKRDPYLAFIAYEKGQNDYELIHITNENAMYKHQARYLVGRADSDLWDY
VLKPDNLHRRSLIDQVVGTAVPESTEPEKVSLAVKAFLAADLPTELIELLEKIILEPSPFSDNQNLQNLLILTAIKADKS
KVSDYIERLDNYDVDDIAQICKENGLNEEAFQVFKKAERHTDALKVLVDDILSLDRAESYAESVDTPEVWSHLGKAQLNG
LRISDAIESYKKANDPSNFAEVIEIASHAGKDEELISFLLMARKTLREPLIDGQLLLSYAATDKLYDLKDLLSSPNVADL
EAIGDELYENKQYEAAKIVFSSISSWAKLASTLVFLNDYQAAVDCARKASSVKVWKQVNEACIEHKEFRLAQICGLNLIV
HAEELQDLVERYEYSGYFDELISLFEQGLVLERAHMGMFTELGILYSKYRPEKLMEHLKLFWSRINIPKVIRSCEAAHLW
PELVFLYCHYDEWDNAALAMIEHSPDAFEHNSFKDVVVKVANLEIYYKAINFYMAEQPQLINDLLNAFIPRVDVSRVVKM
FQKSDNLPMIKPFLIAVQEQNIFAVNNAYHDLLIEEEDYKSLRDSVDSFDRYDPLSLAERLEKHDLIYFRQIAAHLYKKN
KKWNKSISLSKEDKLWKDAIDTAAQSGKSEIAEELLKYFVEIGNKECYVATLYTCYDLIRQDVVSELSWIHDLKDYTMPY
WINVQREQNQLLETLKKDNEERKAKERESEKKEEETPILGSRLMITQGPGSFANGGAPGFLPSQPTGLGF

GO term prediction

Biological Process

GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:0048268 clathrin coat assembly

Molecular Function

GO:0005198 structural molecule activity
GO:0005488 binding
GO:0005515 protein binding
GO:0032051 clathrin light chain binding

Cellular Component

GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0071439 clathrin complex