Protein

MCA_01974_1

Length
652 amino acids

Gene name: GRS1

Description: Glycine--tRNA ligase 1, mitochondrial

Browser: contigA:6009739-6011698+

RNA-seq: read pairs 6979, FPKM 132.1, percentile rank 83.2% (100% = highest expression)

Protein function

Annotation:GRS1Glycine--tRNA ligase 1, mitochondrial
KEGG:K01880GARS glycyl-tRNA synthetase [EC:6.1.1.14]
EGGNOG:0PH5KGRS1Glycyl-tRNA synthetase
SGD closest match:S000000325GRS1Glycine--tRNA ligase 1, mitochondrial
CGD closest match:CAL0000176302GRS1Glycine--tRNA ligase

Protein alignments

%idAln lengthE-value
MIA_06331_182.52%6520.0MIA_06331_1
A0A0J9X3M4_GEOCN79.94%6530.0Similar to Saccharomyces cerevisiae YBR121C GRS1 Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA OS=Geotrichum candidum GN=BN980_GECA02s04861g PE=4 SV=1
A0A1E3PHL0_9ASCO75.96%6530.0Glycyl-tRNA synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46732 PE=4 SV=1
A0A167FI28_9ASCO74.08%6520.0Glycine--tRNA ligase OS=Sugiyamaella lignohabitans GN=GRS1 PE=4 SV=1
A0A060T3Y2_BLAAD74.10%6410.0ARAD1C43978p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C43978g PE=4 SV=1
UniRef50_A0A060T3Y274.10%6410.0ARAD1C43978p n=28 Tax=Fungi TaxID=4751 RepID=A0A060T3Y2_BLAAD
Q5A2A5_CANAL70.97%6510.0Glycine--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GRS1 PE=4 SV=1
Q6C5W5_YARLI72.35%6510.0YALI0E14597p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E14597g PE=4 SV=1
SYG_YEAST70.97%6510.0Glycine--tRNA ligase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GRS1 PE=1 SV=3
A0A1E4T9C8_9ASCO68.73%6460.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_144750 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3265

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 652

Detailed signature matches

  1. Family IPR002315
    Glycyl-tRNA synthetase
    1. PR01043 (TRNASYNTHGLY)
    2. TIGR00389
  2. Domain IPR006195
    Aminoacyl-tRNA synthetase, class II
    1. PS50862 (AA_TRNA_LI...)
  3. Domain IPR002314
    Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
    1. PF00587 (tRNA-synt_2b)
  4. Domain IPR033731
    Glycyl-tRNA synthetase-like core domain
    1. cd00774 (GlyRS-like...)
  5. Domain IPR004154
    Anticodon-binding
    1. SSF52954 (Class II ...)
    2. G3DSA:3.40.50...
    3. PF03129 (HGTP_antic...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.93...
  2. SSF55681 (Class II ...)
  3. cd00858 (GlyRS_anti...)

Residue annotation

  1. dimer interface cd...
  2. motif 1 cd00774
  3. active site cd00774
  4. motif 2 cd00774
  5. motif 3 cd00774
  6. anticodon binding ...

Protein sequence

>MCA_01974_1
MTSTKTAAQPINREALEAVLKRRFFYGPAFDIYGGVSGLYDYGPPGCALQANIVDTWRKHFVLEEDMLEVDTTMLTPHEV
LKTSGHVDKFADWMCKDLATGEIFRADHIVEEVIESRLKGNLEARGLGSEGVKTNDDKKRKKKVKEIKAIKLDDDVVEEY
ETILAKIDGYSGEELGKIIEKHNITNPATGGKLEPPVSFNLMFETAIGPSGQLKGYLRPETAQGQFLNFSKLLDFNNLKM
PFASASIGKSFRNEISPRSGLLRVREFLMAEIEHFVDPKDKTHKNFKEVADIKLKFLPKDVQSAGKTDIIETTVGEAVSS
GMVDNQTLGYFLARVYLFLLKIGVNPDKLRFRQHMQNEMAHYATDCWDAELHSSYGWIECVGVADRSAYDLTVHAARTKE
KLVVRQTLEEPVIVEAYEVEFDKKKFGPKFRKDSPKVETFLTTLTQCELEDLAKQLSSNGKIVVSIEGMEGKVELDDSLI
KIEKKTRKEHVREFTPNVIEPSFGIGRILYCVLEHSFWTRPEDSARGVLSFKPLVAPTKVLVVPLSTQETFVPITHKLVS
NLRKLGIPSKVDDSSASIGKRYSRNDELGTPFGITVDFQTVKDGSITLRERDSTKQVRGSENDVLDAIVAMVNGASWEEG
TKSLAPFESQQE

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006426 glycyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004820 glycine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm