Protein

MCA_01936_1

Length
873 amino acids

Gene name: SCH9

Description: Serine/threonine-protein kinase Sch9; AGC family protein kinase; in S. cerevisiae shown to be functional ortholog of mammalian S6 kinase

Browser: contigA:5917397-5920330-

RNA-seq: read pairs 5956, FPKM 84.2, percentile rank 76.1% (100% = highest expression)

Protein function

Annotation:SCH9Serine/threonine-protein kinase Sch9; AGC family protein kinase; in S. cerevisiae shown to be functional ortholog of mammalian S6 kinase
KEGG:K19800SCH9 serine/threonine protein kinase SCH9 [EC:2.7.11.1]
EGGNOG:0PFAVPGUG_02462serine threonine-protein kinase
SGD closest match:S000001248SCH9Serine/threonine-protein kinase SCH9
CGD closest match:CAL0000175489SCH9Serine/threonine-protein kinase SCH9

Protein alignments

%idAln lengthE-value
MIA_02236_183.10%4970.0MIA_02236_1
A0A0J9X3T7_GEOCN69.27%6150.0Similar to Saccharomyces cerevisiae YHR205W SCH9 Protein kinase involved in transcriptional activation of osmostress-responsive genes OS=Geotrichum candidum GN=BN980_GECA01s05631g PE=4 SV=1
A0A167E964_9ASCO69.84%5470.0Serine/threonine protein kinase SCH9 OS=Sugiyamaella lignohabitans GN=SCH9 PE=4 SV=1
A0A060T3U1_BLAAD66.67%5700.0ARAD1C39622p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C39622g PE=4 SV=1
A0A1E4TLE5_9ASCO63.32%5480.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30703 PE=4 SV=1
UniRef50_G5EB5062.16%5470.0Uncharacterized protein n=117 Tax=leotiomyceta TaxID=716546 RepID=G5EB50_EMENI
A0A1E3PM24_9ASCO65.41%5290.0Kinase-like protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_13458 PE=4 SV=1
Q6C936_YARLI60.94%5760.0YALI0D14542p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D14542g PE=4 SV=1
SCH9_CANAL60.50%5570.0Serine/threonine-protein kinase SCH9 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SCH9 PE=3 SV=2
SCH9_YEAST70.59%4250.0Serine/threonine-protein kinase SCH9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SCH9 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0372

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 873

Detailed signature matches

  1. Domain IPR000008
    C2 domain
    1. PF00168 (C2)
    2. SM00239 (C2_3c)
    3. SSF49562 (C2 domain...)
    4. G3DSA:2.60.40...
  2. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  3. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  4. Domain IPR000961
    AGC-kinase, C-terminal
    1. SM00133 (pkinase_C_6)
    2. PS51285 (AGC_KINASE...)
  5. Domain IPR017892
    Protein kinase, C-terminal
    1. PF00433 (Pkinase_C)
  6. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  7. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.51...
  3. G3DSA:3.30.20...
  4. cd11651 (YPK1_N_like)
  5. mobidb-lite (disord...)

Protein sequence

>MCA_01936_1
MIGSEMRISVYDFACFGSVYRLSPHGTSLQNGSKLVPSINNNPYLISESNYKPAQTSSLCQSPAISTIINTVLNSSTTSL
DYSNNSLSNSNSSSLPNSVSNSTNSPSASSSITSSSTEKSPSSKSACPEPISPFSQYLARFTPSYSASTTAISPQTAEVS
SCISVNKHIPGSILRNKEIPILATHSNTLYSSNSELQIRNKNKTNFKQNNLSLDSILVSTNISNTKTPITNNEMLASQDT
SVMSSSSTKPTSNNNISSQLSQFNQLGTTPSKINATSLSDVATPNTENVAVCGKLKVRITEAHDVFVPSPNTSPYVVCTF
NSSEFITHEAPSSSTSSSAETGSSKPTGIAIPTRQSTSAFTALFNKVKGTAGTTTSPSSTPGNPKWTDEAQFDVTSEQAD
IDISIYDAQADDAFLGRVLIHTNLLKEPNFDQWIPLQPRGSGDRVTGEVHVQMKYEPVRNRSIGPDDFEILRLVGKGTFG
QVYQVRKKDTQRIYAMKVLSKKIIVQKKEIAHTIGERDILVRTALSDSNFIVGLKFSFQTPTDLYLVTDYMSGGELFWHL
QKESRFSEERAKFYIAELIIALEHLHDNDIVYRDLKPENILLDANGHIALCDFGLSKANLSDNGTTNTFCGTTEYLAPEV
LLDDKGYTKMVDFWSLGVLVFEMCCGWSPFYAEDVQQMYKNIAFGKVRFPKDALSHDGRNFVKGLLNRNPRHRLGANGDT
RELKAHPFFKDIDWDALAAKLIPPPFKPVISSETDTSNFDPEFTQASTSVLKKGFLPMGSTPLSPGIQAKFQGFTYVDES
SMDHHMQSRLGTSLRPVEYREDDIELYDDNDIESAVQYNTDHGLSNNQLLEDEDVGMSDDDDDGYVNGQRFEM

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.