Protein
MCA_01928_1
Length
1,045 amino acids
Gene name: MUS81
Description: Crossover junction endonuclease MUS81
Browser: contigA:5889853-5892991-
RNA-seq: read pairs 1027, FPKM 12.1, percentile rank 29.4% (100% = highest expression)
Protein function
| Annotation: | MUS81 | Crossover junction endonuclease MUS81 | |
|---|---|---|---|
| KEGG: | K08991 | MUS81 | crossover junction endonuclease MUS81 [EC:3.1.22.-] |
| EGGNOG: | 0PIJ7 | MUS81 | Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) |
| SGD closest match: | S000002794 | MUS81 | Crossover junction endonuclease MUS81 |
| CGD closest match: | CAL0000174024 | MUS81 | Crossover junction endonuclease MUS81 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02245_1 | 46.60% | 324 | 1e-86 | MIA_02245_1 |
| A0A0J9X6G7_GEOCN | 47.88% | 307 | 4e-88 | Similar to Saccharomyces cerevisiae YDR386W MUS81 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA OS=Geotrichum candidum GN=BN980_GECA03s06533g PE=4 SV=1 |
| UniRef50_A0A0J9X6G7 | 47.88% | 307 | 8e-85 | Similar to Saccharomyces cerevisiae YDR386W MUS81 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X6G7_GEOCN |
| A0A161HHT1_9ASCO | 42.77% | 318 | 1e-78 | Mus81p OS=Sugiyamaella lignohabitans GN=MUS81 PE=4 SV=1 |
| A0A060T3F0_BLAAD | 43.00% | 307 | 2e-68 | ARAD1C39996p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C39996g PE=4 SV=1 |
| A0A1E3PF61_9ASCO | 40.46% | 304 | 1e-62 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53046 PE=4 SV=1 |
| MUS81_CANAL | 38.19% | 309 | 3e-61 | Crossover junction endonuclease MUS81 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MUS81 PE=3 SV=1 |
| MUS81_YEAST | 35.06% | 308 | 2e-48 | Crossover junction endonuclease MUS81 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MUS81 PE=1 SV=1 |
| A0A1E4TFA0_9ASCO | 32.19% | 320 | 8e-41 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_11718 PE=4 SV=1 |
| Q6CBW4_YARLI | 30.99% | 313 | 7e-33 | YALI0C14960p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C14960g PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0448
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
800
900
1045
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_01928_1 MSGEVLESWNDIFLSWLKEFADSAQGNPGAFNYKTIYTRAISSLKACPKEFNHASELKELKYFGPSICSTLEKKQEQYCS AHGIQMPPKFSRRRNQVRAETSIDGPSTSISGTAATSSSSSSSRRNTVPAPANSNIYVHSTHNNPSVSSPLLNNPYATRF SNNVMPNASSSRSAQPAPTSRTSTSSSSTSIPPLTPSTSNPAASPLTSPAIIEALQELNNSTSNPATRRKRNAGVYIPKY RSGGYAILLTLYHQATMNGQGMCKADIIKVAHTLCDTSFAPDPGNGVYYSAWNNINTLMKKGLVCPSSLRNPIYSITEEG RHVAEGILKAEQEASAGGASEASSSRASTSNTATSRSNINISNNTKRPTVSLTEEELLVLLGRGDLDLGKAFATSVRPNP RPTSETISSASPGKTLGAIPGTTGQPLYNTINEHQRYHKNPSGTNNGNLSAAYKEKGKAATKTKQDGKDSPIIVIDGDSD EEIIQDSKPSSFKTKDKNSKVNSFRHDLQKSSLKEKEINNNNTSEDFTILDSSVKRKTPASDASDVFQTPRHIKLARTAI NSSSPSAYSYVAINGNNNSNHDKVVHSSPITNNDVAPADMTPNSYVRAQLRQLGLVNQNYNSPTGSSQNSNRSNFEFPTS SPPPPIDEEIENIDESQYSKASLTGSPVSSKNSKKSELVAPNNANLVKSFYTSTPSFIRTGITNGNTNSNINNININNSN NNNNRKKQLEDGRYLRRVWPAGTFTIELFIDNREIRSQSERDFFVNTLSQKYRVPCRVENLTVGDLLWVAKEKNTGQIAV VDFIIERKRLDDLVASIKDGRFAEQKLRLKRSGLANITYLVEELVAMDKGIYAQQIQTAMSQVITHDGFFLKRTLNTEET VAVLAEMTAKIKEMYQGTDLYVVSPQLNTHKSYDLAIRKVRAKIQYRNTNSTNGKPILSLGIDYGSFQTALSKTAMVTIR DVFIDMLLTVKGITMDKAKVIQKKYPTPRFLLEAYQREYASQESPEKGDAVVKDMLFNDFGHLITKQRITKVLSEKIYQV WGKFL
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
Cellular Component
None predicted.