Protein

MCA_01873_1

Length
1,025 amino acids

Gene name: DIS3

Description: Exosome complex exonuclease DIS3

Browser: contigA:5740230-5743308-

RNA-seq: read pairs 3076, FPKM 37.0, percentile rank 58.6% (100% = highest expression)

Protein function

Annotation:DIS3Exosome complex exonuclease DIS3
KEGG:K12585DIS3 exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
EGGNOG:0PHAGDIS3exosome complex exonuclease
SGD closest match:S000005381DIS3Exosome complex exonuclease DIS3
CGD closest match:CAL0000184500orf19.5229Exosome catalytic subunit

Protein alignments

%idAln lengthE-value
MIA_02498_172.74%10270.0MIA_02498_1
A0A0J9XCY1_GEOCN72.21%10220.0Similar to Saccharomyces cerevisiae YOL021C DIS3 Exosome core complex catalytic subunit OS=Geotrichum candidum GN=BN980_GECA08s02925g PE=3 SV=1
A0A167EF70_9ASCO66.28%10410.0Exosome catalytic subunit DIS3 OS=Sugiyamaella lignohabitans GN=DIS3 PE=3 SV=1
A0A1E3PJC7_9ASCO63.35%10260.0Exoribonuclease required for 3 end formation of 5.8S rRNA OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83142 PE=3 SV=1
A0A060SYB3_BLAAD64.95%10270.0ARAD1A11088p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A11088g PE=3 SV=1
Q6C755_YARLI61.86%10200.0YALI0E03630p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E03630g PE=3 SV=1
RRP44_YEAST57.97%10350.0Exosome complex exonuclease DIS3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DIS3 PE=1 SV=1
UniRef50_Q0816257.97%10350.0Exosome complex exonuclease DIS3 n=37 Tax=Saccharomycetales TaxID=4892 RepID=RRP44_YEAST
Q5A3P1_CANAL57.85%10440.0Exosome catalytic subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5229 PE=3 SV=1
A0A1E4TKJ0_9ASCO51.65%8460.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_55977 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7189

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1025

Detailed signature matches

  1. Domain IPR029060
    PIN domain-like
    1. G3DSA:3.40.50...
    2. SSF88723 (PIN domai...)
  2. Domain IPR002716
    PIN domain
    1. PF13638 (PIN_4)
    2. SM00670 (PIN_9)
  3. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  4. Domain IPR033771
    Rrp44-like cold shock domain
    1. PF17216 (Rrp44_CSD1)
  5. Domain IPR033770
    Exosome complex exonuclease RRP44, S1 domain
    1. PF17215 (Rrp44_S1)
  6. SITE IPR022966
    Ribonuclease II/R, conserved site
    1. PS01175 (RIBONUCLEA...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. PF00773 (RNB)
  3. SM00955 (RNB_2)
  4. cd09862 (PIN_Rrp44)

Residue annotation

  1. exosome subunit in...
  2. putative active si...

Protein sequence

>MCA_01873_1
MTTLQKRSFDKPHISVSQKVFIRSSKAGNASKVFREQYLRTDIPCSSALCSVCPLNTPPAADGSILPPVLARDPNKTTKR
GPHYLIIDTNIALKAIDVLELKSAFFDVIVPQVVLEEVRNRSLPVYTRLRTLSKNADEKRFYVFHNEFHKETHIIREKNE
TINDRNDRAIRQVALFYQNHLQENAKALSDEFRVPIPQIVLLTDDRANREKANAQNIEALSLVDYINELKNANDILDMLP
SDDFTDKSSSSKNTTESFYPDYYPQSRVLGGIKNGTLFRGKLEINRYNFLEGSVSTRAYPRPILILGRQNLNRGFNGDTV
VVELLPKSMWKKPSSQVVEEDQLDGADAADNEDQAIVNDYERKILAQEALKAQQEKHENVESRLQPTAKIVAIEKRSWRL
YVGHIVDSSIPQDANISNSFKYVFFSPLDRCIPRIKIKTRKAAALMGKRIVVAVDAWNSTSKYPEGHFVRDLGEIESQEA
ETEALLLEYDVEYRPFPKSVLKCLPPEGHNWKVPENLNNGDPFLAKRRDLRDRLVCSIDPPKCQDIDDALHARLLPNGNY
EVGVHIADVTHFVKPNTPLDEEGASRGTSVYLVDKRIDMLPMLLGTDLCSLKPKVERYAFSVLWELTPDAKIVNTEFTKS
IIRSREAFEYSEAQARIDDASLTDELTLGMRALCGLSKKLKQQRLDNGALNLASPEVKVHVDSETSDPNEVEIKQLLDTN
SLVEEFMLLANISVARQIYKAFPQTAMLRRHAPPPVSNFDILNEQLRVKKNGMQIDVSNSKALADSLDNIVDPEDPFFNT
LVRIMATRCMMAAEYFSSGSFSYPEFRHYGLATDIYTHFTSPIRRYADVVAHRQLAASIGYEPLEQSHRDQDKMQAICQN
INKRHRNAQFAGRASIEYYVGQVLKTMGEKKGENSDVKDGDNIQEGYIIKVFSNGISILVPKFGVESLIHLEDLGVPESA
QYIEETFTLEIMPKSDASSSAKSKKSTKTEQPKMRQLSIFDKILVNVKSVKDESSGKRKVKMELV

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.