Protein

MCA_01847_1

Length
742 amino acids

Gene name: YME1

Description: Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1

Browser: contigA:5661619-5663848-

RNA-seq: read pairs 4779, FPKM 79.5, percentile rank 75.2% (100% = highest expression)

Protein function

Annotation:YME1Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
KEGG:K08955YME1 ATP-dependent metalloprotease [EC:3.4.24.-]
EGGNOG:0PFTBFG01475.1intermembrane space AAA protease IAP-1
SGD closest match:S000006228YME1Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
CGD closest match:CAL0000179642YME1I-AAA protease

Protein alignments

%idAln lengthE-value
MIA_04319_178.77%6640.0MIA_04319_1
A0A0J9X673_GEOCN76.26%6360.0Similar to Saccharomyces cerevisiae YPR024W YME1 Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex OS=Geotrichum candidum GN=BN980_GECA03s05323g PE=3 SV=1
A0A161HIZ3_9ASCO73.90%6590.0I-AAA protease YME1 OS=Sugiyamaella lignohabitans GN=YME1 PE=3 SV=1
A0A060T975_BLAAD74.46%6500.0ARAD1C41602p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C41602g PE=3 SV=1
A0A1E3PM48_9ASCO63.47%6460.0ATP-dependent metallopeptidase Hfl OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45951 PE=3 SV=1
A0A1D8PME0_CANAL66.13%6230.0I-AAA protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=YME1 PE=3 SV=1
Q6CG28_YARLI63.35%6330.0YALI0B01386p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B01386g PE=3 SV=1
UniRef50_A0A0H5C8A563.81%6410.0YME1 protein n=20 Tax=saccharomyceta TaxID=716545 RepID=A0A0H5C8A5_CYBJA
A0A1E4TIF0_9ASCO63.49%6410.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_71768 PE=3 SV=1
YME1_YEAST60.77%6500.0Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YME1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9554
Predicted cleavage: 116

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 742

Detailed signature matches

  1. Family IPR005936
    Peptidase, FtsH
    1. MF_01458 (FtsH)
    2. TIGR01241
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
  4. Domain IPR003959
    ATPase, AAA-type, core
    1. PF00004 (AAA)
  5. Domain IPR000642
    Peptidase M41
    1. PF01434 (Peptidase_M41)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.8.60
  3. G3DSA:3.40.50...
  4. NON_CYTOPLASM... (N...)
  5. SIGNAL_PEPTIDE (Sig...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. SIGNAL_PEPTID... (S...)
  9. SSF140990 (FtsH pro...)
  10. cd00009 (AAA)
  11. mobidb-lite (disord...)

Residue annotation

  1. Walker A motif cd0...
  2. ATP binding site c...
  3. Walker B motif cd0...
  4. arginine finger cd...

Protein sequence

>MCA_01847_1
MIKQYMKNSSIRPLMSAKPRMLASLHKSSTLLSTPVTLSTLRPGIQLTQKRYISLFPSSWSLNPQASSSSTPISTATLHT
KEQQANRGLSNASLQVDFYKSLLAANYPNVVISRYETPGVARNAEADSLYLTALRAVGDVEKASRVEAQLANNPNPASDS
NQQYYNAGAGSPFGYSSSKGTSAEPLHVVIDESALSIALKWLKWLVPMGLAGWAIMSGLSFFSESSIGSSIFKGDNSNEI
SSSKVVDETNGTQSKVRFSDVQGVDEARAELEEVVEFLKDPSKFTGLGGKLPKGILLTGPPGTGKTLLARAVAGEAGVPF
FFMSGSEFDELYVGVGAKRVRELFAAARSKAPAIVFIDELDAIGGKRNPKDHAYSKQTLNQLLVDLDGFSQTTGVIFIAA
TNFPEMLDKALTRPGRFDKIVHVELPDVRGRIAILKHHMKKVETSSDVDPSVIARGTSGFSGADLMNLVNQAAVHASREK
AVAVDMSHFEWAKDKILMGAARKTMVLTEETRRNTAFHEAGHAIMSLYTPGATSLYKATILPRGSALGITFQLPEMDKYD
QTKKELLARLDVCMGGKIAEEMINGPESVTSGCSSDLKQATQVATAMVTSYGMSDAIGPVQLSENWNNWSASTRHLAEQE
IRRLLVESEERTRKMLKERQLELQRLAEGLLEYETLDKEDIERVVEGQKIQKEKTITNIVVKSDDIRDKRTKTPQRQPAK
NASSSSTRPSKPVPENLDPANE

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004222 metalloendopeptidase activity
GO:0005524 ATP binding

Cellular Component

GO:0016020 membrane