Protein

MCA_01844_1

Length
1,537 amino acids

Gene name: MPH1

Description: ATP-dependent DNA helicase MPH1

Browser: contigA:5653643-5658257-

RNA-seq: read pairs 359, FPKM 2.9, percentile rank 13.6% (100% = highest expression)

Protein function

Annotation:MPH1ATP-dependent DNA helicase MPH1
KEGG:K14635MPH1 ATP-dependent DNA helicase MPH1 [EC:3.6.4.12]
EGGNOG:0PH1AMPH1ATP-dependent DNA helicase involved in error-free DNA damage bypass through homologous recombination (By similarity)
SGD closest match:S000001441MPH1ATP-dependent DNA helicase MPH1
CGD closest match:CAL0000186482MPH1ATP-dependent DNA helicase MPH1

Protein alignments

%idAln lengthE-value
MIA_00551_156.76%7100.0MIA_00551_1
A0A0J9XD97_GEOCN52.03%6400.0Similar to Saccharomyces cerevisiae YIR002C MPH1 3'-5' DNA helicase involved in error-free bypass of DNA lesions OS=Geotrichum candidum GN=BN980_GECA11s02166g PE=4 SV=1
UniRef50_A0A0J9XD9752.03%6400.0Similar to Saccharomyces cerevisiae YIR002C MPH1 3'-5' DNA helicase involved in error-free bypass of DNA lesions n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XD97_GEOCN
A0A167FM35_9ASCO50.00%6340.0Mph1p OS=Sugiyamaella lignohabitans GN=MPH1 PE=4 SV=1
A0A060T8R3_BLAAD46.43%6441e-180ARAD1C31174p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C31174g PE=4 SV=1
MPH1_YEAST41.96%7342e-152ATP-dependent DNA helicase MPH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MPH1 PE=1 SV=1
MPH1_CANAL40.80%6471e-142ATP-dependent DNA helicase MPH1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MPH1 PE=3 SV=2
Q6CB95_YARLI42.47%5843e-143YALI0C20933p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C20933g PE=4 SV=2
A0A1E4TFT4_9ASCO51.94%2063e-73Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20243 PE=4 SV=1
A0A1E3PM39_9ASCO71.43%1192e-52p-loop containing nucleoside triphosphate hydrolase protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82298 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0352

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1537

Detailed signature matches

  1. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  2. Domain IPR006935
    Helicase/UvrB, N-terminal
    1. PF04851 (ResIII)
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.20.13...
  2. G3DSA:3.40.50...
  3. cd00046 (DEXDc)
  4. cd00079 (HELICc)
  5. cd12091 (FANCM_ID)
  6. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. putative helicase ...
  4. nucleotide binding...
  5. ATP-binding site c...

Protein sequence

>MCA_01844_1
MMISDTEFDSFFDGIDDNEIENYISSSMTPSSKSVSSSNESSCGNQSQPSQLSLPAQPQQKITIETPTRPRSNNSNSIII
ENEEENIDPEGSSSLKSRKENSNTRQTTISGDYSMMVGRYPGTMKPPEAQPSTNQSVIETQRTMGSRPAFFEELRDREQH
RKVFHQLNEDALSTYIYPTNLPEREYQFNIVKTALFQNTLCALPTGLGKTFIASTVMFNFYRWSKTAKIIFMAPTRPLVS
QQLHACLGITGINYSDASILMGNMSAPIREREWQEKRLFFATPQTVNNDLKSGILDPKSIICLVVDEAHRSTGNQAFAEV
VKFISRFNPCFRVLALTATPSSTVEGVQEIIDNLNLSKVEIRTEDSMDIQPYIHKKDIQRIKVEMSDEQKELMECFEPCV
KPLLDEAKACKAIFIQDVSQLTLFGVNSARQKYMASPAGRSNNPLKFKILGILKVLTPLGYAIQQLKLQGITTFYSLIKK
FEEDSVKSKSKYIKKVISHEGFHQTLRLCEKMMSRIGNMANPFLSHPKMQHLISIVTAFFGSPDLDENSRVIVFAMYRET
TSEIVEMLSKYVYECRPHSFVGQSAVKKGTGTVDTEAATKSAAGMTQKEQQKVISEFKQGKYNTLVATSIGEEGLDIGEV
DLIVCYDSSASPIKALQRMGRTGRKRNGKIYMLLTESEEKKFDMSLDNYKYIQKLITDNRRLQYHKVDRILPLTVNPECE
KRFIEIPKENEEILQSEDPLKDIESTQRGKKISKRRKIEKRFHMPDDVQTGFVKASSLDNFLHKPSSGTNESDTIDLSIL
SDDDEDDARNTSINTTSNKDFEDEDDDDLFGETTNSPNQTFNTPKRVPSASSSSSSSVLKSLSKLNSTHSPLSGFRFGAK
AQTPTKQTGNLNDSPGLEITSPIMTTPNIINGQSTPKNMTNKNSIPMGNNKPKDTSFDELDINASCIPRRNRLGISDENP
GAESPIKSNKATPKKNKGKSKAKPSSSIFSIEEEKQKEEEEMNILSDIVDSPQPIIIPQKEVETPITKEKKKRKKPQKMD
EILDYIPEQDGPDFGVLIPEVESQVETALSNMMQGQPYSFNFNSKTKKLINMGKHVVASICKNKKPTKTRIPRSSLFNLL
LSSSSSSSEIENKRKKNSKVVEELGQITANDYYKMKNDYKAMINDIDEGIDVEDFIVDDDNISKPLLTSPARKLKKKGSS
SNVDVNSTKDDNSTTITTITTITTTPKKLFNNNQKEPLDDLIEICSPPQLVSPSEKKTPRKRVSDTYYDDETVESIRQSK
KRVTNNKSSSSSSSSLLKKGTNTATATNMGPPSNTKPRSTVRSKTILPPSTSSISNRANSKKKKRNSVSITEEDFDFDDD
NIDENNNTFGEPTDEEERGMGDACLDEEERGMGDACLDEEERSEDDEDDHGTDLEDFVAEDDEDFGNVTSSYDINKEPIS
SSDDDEDYDNDNDVGLVIRSEDEEEEECNSSFDYSFSHHSVNNKNNNKNRFGKQQKEPEIIDLSMSQSQPENIVIESEKE
DDDDDLEITSDISTSVY

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

Cellular Component

None predicted.