Protein

MCA_01815_1

Length
883 amino acids

Gene name: KEX2A

Description: Kexin

Browser: contigA:5522258-5524910+

RNA-seq: read pairs 1740, FPKM 24.3, percentile rank 46.9% (100% = highest expression)

Protein function

Annotation:KEX2AKexin
KEGG:K01341KEX2 kexin [EC:3.4.21.61]
EGGNOG:0PF8EKEX2Kex protein
SGD closest match:S000005182KEX2Kexin
CGD closest match:CAL0000186377KEX2Kexin

Protein alignments

%idAln lengthE-value
MIA_02377_167.72%6320.0MIA_02377_1
A0A0J9X5E7_GEOCN63.28%6290.0Similar to Saccharomyces cerevisiae YNL238W KEX2 Subtilisin-like protease (Proprotein convertase) OS=Geotrichum candidum GN=BN980_GECA03s04839g PE=3 SV=1
UniRef50_A0A0J9X5E763.28%6290.0Similar to Saccharomyces cerevisiae YNL238W KEX2 Subtilisin-like protease (Proprotein convertase) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5E7_GEOCN
A0A167F2Y9_9ASCO54.09%6600.0Kexin KEX2 OS=Sugiyamaella lignohabitans GN=KEX2 PE=3 SV=1
A0A060TCW0_BLAAD47.96%7590.0ARAD1D46200p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D46200g PE=3 SV=1
A0A1E3PL06_9ASCO48.90%6830.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_74391 PE=3 SV=1
A0A1D8PEG3_CANAL49.07%6460.0Kexin OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KEX2 PE=4 SV=1
KEX2_YEAST47.01%6363e-176Kexin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KEX2 PE=1 SV=1
A0A1E4TE22_9ASCO53.40%4704e-164Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_17972 PE=4 SV=1
XPR6_YARLI55.27%4741e-155Dibasic-processing endoprotease OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=XPR6 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2515

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 883

Detailed signature matches

  1. Family IPR015500
    Peptidase S8, subtilisin-related
    1. PR00723 (SUBTILISIN)
  2. Domain IPR000209
    Peptidase S8/S53 domain
    1. PF00082 (Peptidase_S8)
    2. G3DSA:3.40.50...
    3. SSF52743 (Subtilisi...)
  3. Domain IPR034182
    Kexin/furin catalytic domain
    1. cd04059 (Peptidases...)
  4. Domain IPR008979
    Galactose-binding domain-like
    1. SSF49785 (Galactose...)
    2. G3DSA:2.60.12...
  5. Domain IPR002884
    Proprotein convertase, P
    1. PF01483 (P_proprotein)
  6. SITE IPR023827
    Peptidase S8, subtilisin, Asp-active site
    1. PS00136 (SUBTILASE_ASP)
  7. SITE IPR022398
    Peptidase S8, subtilisin, His-active site
    1. PS00137 (SUBTILASE_HIS)
  8. SITE IPR023828
    Peptidase S8, subtilisin, Ser-active site
    1. PS00138 (SUBTILASE_SER)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SignalP-noTM
  8. TMhelix
  9. TRANSMEMBRANE (Tran...)
  10. mobidb-lite (disord...)

Residue annotation

  1. calcium binding si...
  2. active site cd04059
  3. catalytic triad cd...
  4. calcium binding si...
  5. calcium binding si...

Protein sequence

>MCA_01815_1
MRLQYVYWLTFIANAFASSAFPINKERDLDNRIYFAVEIDPRRLSTSPEAHFRNSDHQIPQSWTYEQPIYAVPNHYLFSI
PKSDQNADMLMDIGPHARGSKFDKRSPEHLLLKRHLLDSGVNSLEVFEPRKLYKRSVIPEPEPLPYKVDSSIQAIEDMAA
KFGIKDPIFNRQWHLFNPVQPGHDINVTGAWEQDVTGKGVSICVIDDGLDLDSKDLKDNFFPEGSWDFNNPGPYPRPRLA
DDRHGTRCAGEIAAVKNDVCGVGVAYNANIAGVRILSKRILPADEALSINYAMDKNDIYSCSWGPSDNGRTMEGPPAIVS
KAMLNAIQNGRKKKGNIYVFASGNGGSLDDNCNFDGYTNSIYSITIAAIDRKGLHPFYSEACSANMVVTYSSGSGDYIHT
TDVEGSCSHTHGGTSAAAPIAAGIFSLVLEVNPEITWRDMQYLVWETAVKNNEEPGWQKTPSGKYYHHTYGYGKLDAYGI
VEKARTWKNVKPQAWFHQQTKMENVDIPEDGSEKVFTTTVTEDDLKKANLERLEHIQVKINADSSRRGSLTMTLESPSGV
KSEIMMKRRSDSATQGVVDWKFMSVAHWGESGVGEWKLTVKHVTAGKVSSRLIDWQLLLWGESIDASKAKPFPGVDGANL
DVSTSSSVSEEHTGTKTSQPVKEETSTKAGEPEAETSSSFVAQPTTTAVESSTPDENHKGEENNGDDDEKEDSGNHGFFG
SLIPTFGMSKNTAAWVYGSGLIIILFIGGITGYLLWIRRKRNGDGDYKGFNPLLGNGNRRDEELGDELDYLNEFSISDEE
DEYSDDGDANSQRSSHSNLLAGTSENVVNRDGSELTAGKKAVDLYSSPALTAAQPSKKDEENEPLFSSDEEFENSKNGSG
SNK

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

None predicted.