Protein

MCA_01811_1

Length
1,241 amino acids

Gene name: PKC1

Description: Protein kinase C-like 1, serine/threonine protein kinase; in S. cerevisiae essential for cell wall remodeling during growth; localized to sites of polarized growth.

Browser: contigA:5513970-5517784+

RNA-seq: read pairs 4264, FPKM 42.4, percentile rank 61.7% (100% = highest expression)

Protein function

Annotation:PKC1Protein kinase C-like 1, serine/threonine protein kinase; in S. cerevisiae essential for cell wall remodeling during growth; localized to sites of polarized growth.
KEGG:K02677PRKCA classical protein kinase C alpha type [EC:2.7.11.13]
EGGNOG:0PHX3PKC1protein kinase C
SGD closest match:S000000201PKC1Protein kinase C-like 1
CGD closest match:CAL0000201435PKC1Protein kinase C

Protein alignments

%idAln lengthE-value
MIA_02351_169.39%6730.0MIA_02351_1
A0A0J9XAB5_GEOCN63.97%6300.0Protein kinase C OS=Geotrichum candidum GN=BN980_GECA05s06742g PE=3 SV=1
A0A060T3J5_BLAAD59.23%6230.0Protein kinase C OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A16126g PE=3 SV=1
A0A1E3PEG1_9ASCO54.68%6310.0Kinase-like protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_6295 PE=3 SV=1
A0A167D888_9ASCO64.84%4920.0Protein kinase C OS=Sugiyamaella lignohabitans GN=PKC1 PE=3 SV=1
UniRef50_V5FLX551.20%6250.0Protein kinase C-like protein (Fragment) n=3 Tax=Pezizomycotina TaxID=147538 RepID=V5FLX5_BYSSN
Q6C292_YARLI78.76%3390.0Protein kinase C OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09746g PE=3 SV=1
A0A1E4TBY5_9ASCO76.20%3530.0Protein kinase C OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_58235 PE=3 SV=1
KPC1_YEAST46.18%6152e-170Protein kinase C-like 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKC1 PE=1 SV=3
Q5ANK2_CANAL70.88%3401e-170Protein kinase C OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PKC1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3517

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Repeat
1 200 400 600 800 1000 1241

Detailed signature matches

  1. Domain IPR000008
    C2 domain
    1. PF00168 (C2)
    2. SM00239 (C2_3c)
    3. SSF49562 (C2 domain...)
    4. G3DSA:2.60.40...
  2. Domain IPR002219
    Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    1. PS00479 (ZF_DAG_PE_1)
    2. PF00130 (C1_1)
    3. cd00029 (C1)
    4. SM00109 (c1_12)
    5. PS50081 (ZF_DAG_PE_2)
  3. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  4. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  5. Domain IPR000961
    AGC-kinase, C-terminal
    1. SM00133 (pkinase_C_6)
    2. PS51285 (AGC_KINASE...)
  6. Domain IPR017892
    Protein kinase, C-terminal
    1. PF00433 (Pkinase_C)
  7. Repeat IPR011072
    HR1 rho-binding repeat
    1. SSF46585 (HR1 repeat)
    2. SM00742 (hr1_7)
    3. PF02185 (HR1)
  8. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  9. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.28...
  3. G3DSA:1.10.51...
  4. G3DSA:1.20.10...
  5. G3DSA:3.30.20...
  6. G3DSA:3.30.60.20
  7. SSF57889 (Cysteine-...)
  8. SSF81995 (beta-sand...)
  9. cd05570 (STKc_PKC)
  10. cd11620 (HR1_PKC-li...)
  11. mobidb-lite (disord...)

Residue annotation

  1. putative Rho bindi...
  2. putative Rho bindi...
  3. zinc binding sites...
  4. putative DAG/PE bi...
  5. putative RAS inter...
  6. zinc binding sites...
  7. putative DAG/PE bi...
  8. putative RAS inter...
  9. ATP binding site c...
  10. active site cd05570
  11. polypeptide substr...
  12. activation loop (A...
  13. turn motif phospho...
  14. hydrophobic motif ...

Protein sequence

>MCA_01811_1
MNNSSSSQDDRVIQDIHKKIGREKGIVQGAISLKSSTSNVSVQQKCDSNIREAQKNIEYLEERLRQLEIRKRNSVSSGSI
AFQSHNTNSSDPNSANSNIPSTPNNSSYLNAASSNASFNQLSPYNKNHERSYSNGINASPGPESAPTRPNFTRLDLLKYD
TPYLGPRIQLMLQQLEFKLNVEKEYKKGVDKMIHLYQLEGDKRSKSEAEGKRLESTQKVTLLTKSLKRYTDVHIDFEEDF
GDDESLLHANLRRPLTGKLHIACRAVKDVDHYATSRPTKSPESFITVKVEDQTRAKTRISRNDHWNEEFDISVDKANEIE
IVVYDRSMDRDIPIGLMWLRISDIAEAIRRKKVEQELHPGWVSASKVQSDLPTGGSSYPLTNNSNSNNSSSAPYLAQNQQ
KGQSSNTQSNSITIDSWFVLEPVGRIHLTLGFEKTNRGPRHENNGGLGRQGAIRQKKEEVHEMHGHKFVQKNFYNIMRCA
LCGDFLKYSGGYQCMDCNYTCHKKCYPKVVTKCISKASTETDPDEEKLNHRIPHRFEKITNMSANWCCHCGYMLPLGKKN
VRKCTECGLTAHAQCVHLIPDFCGMSMEMANQIISEIRSTRDRKAANQHIKSASVGNIQVSPNRINQLQANQQLQSQNIP
HFAQKPAFGQPQPIKPTQSVPTEISVQQSQIRQVQPQDHYQQGNQYPQKQQQPQTPLPPKQHISSQFPQLQPSQQQAYSQ
PDRVSPRSSPSPPPQRGQVKRKDVSSSRRSPSPGTQAHSTSSPLESSSDLTLGSNKSPSPISAASAAMNSLRPSVSHPDQ
YQTGKQVASPRQGSVGSHDVSDSISYSSPKSEYQDQSAIYQQQQQQLQQQAQLQAQQQAQQQAQQAHQAQQEAQQQAQLE
QQQQLELQQQQGKQVQKHAPKSPRRPRRKVGLDDFNFLAVLGKGNFGKVMLAESRTTQNLYAIKVLKKDFIIENDEVEST
RSEKRVFLIANREKHPFLLNLHSCFQTENRVYFVMEYISGGDLMWHIQQIPFTPRRAQFYAAEVLLALKYFHENGVIYRD
LKLDNILLTLSGHIKIADYGLCKEEMWYGNTTGTFCGTPEFMAPEILSEQKYGRSVDWWAFGVLIYQMLLGQSPFRGDDD
DEVFDAILLDEPLYPIHMPRDSVSILQGLLTREPQKRLGSGPRDAEEIMEHAYFKNINFDDIYHCRVPPPFVPQIDSPTD
VRNFDQEFTNETPALTPVNSTLTPEMQEKFRGFSYLNGDVI

GO term prediction

Biological Process

GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.