Protein

MCA_01796_1

Length
640 amino acids

Gene name: SDH1

Description: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Browser: contigA:5480317-5482345-

RNA-seq: read pairs 48166, FPKM 928.5, percentile rank 96.4% (100% = highest expression)

Protein function

Annotation:SDH1Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
KEGG:K00234SDHA succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
EGGNOG:0PFY0SDH1succinate dehydrogenase, flavoprotein subunit
SGD closest match:S000001631SDH1Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
CGD closest match:CAL0000178926SDH1Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Protein alignments

%idAln lengthE-value
MIA_02390_188.47%6420.0MIA_02390_1
A0A0J9X752_GEOCN85.34%6410.0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Geotrichum candidum GN=BN980_GECA04s02518g PE=3 SV=1
A0A060THI6_BLAAD82.39%6360.0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38764g PE=3 SV=1
A0A1E3PML1_9ASCO80.50%6460.0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82425 PE=3 SV=1
A0A167E825_9ASCO84.56%6090.0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Sugiyamaella lignohabitans GN=SDH1 PE=3 SV=1
Q6C9G6_YARLI79.88%6410.0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D11374g PE=3 SV=2
A0A1E4TIM6_9ASCO83.61%5980.0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_72911 PE=3 SV=1
UniRef50_A0A1J7K0H479.74%6170.0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial n=1 Tax=Coniochaeta ligniaria NRRL 30616 TaxID=1408157 RepID=A0A1J7K0H4_9PEZI
SDHA_YEAST75.62%6440.0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SDH1 PE=1 SV=1
Q5A2A1_CANAL74.37%6360.0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SDH1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9626
Predicted cleavage: 28

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 640

Detailed signature matches

  1. Family IPR014006
    Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
    1. TIGR01812
  2. Family IPR011281
    Succinate dehydrogenase, flavoprotein subunit
    1. TIGR01816
  3. Domain IPR023753
    FAD/NAD(P)-binding domain
    1. G3DSA:3.50.50.60
    2. SSF51905 (FAD/NAD(P...)
  4. Domain IPR003953
    FAD-dependent oxidoreductase 2, FAD binding domain
    1. PF00890 (FAD_binding_2)
  5. Domain IPR027477
    Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
    1. SSF56425 (Succinate...)
  6. Domain IPR015939
    Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
    1. PF02910 (Succ_DH_fl...)
    2. SSF46977 (Succinate...)
    3. G3DSA:1.20.58...
  7. SITE IPR003952
    Fumarate reductase/succinate dehydrogenase, FAD-binding site
    1. PS00504 (FRD_SDH_FA...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:4.10.80.40
  2. PIRSF000171 (SDHA_A...)

Protein sequence

>MCA_01796_1
MLSALRRSCLRKQNLNIRAFHSSRTVGSIVSQEPIKAHEASSHLTKKYAVIDHEYDAVVVGAGGAGLRAAFGLANAGFNT
ACISKLFPTRSHTVAAQGGINAALGNMHPDDWHWHMYDTVKGSDWLGDQDAIHYMTREAPQSIIELEHFGMPFSRTEEGK
IYQRAFGGQSKDYGHGGQAYRTCAVADRTGHAMLHTLYGQSLRHNTNFFIEFFALDLLMQDGKCVGVIAYNQEDGTIHRF
KSKNTVIATGGFGRAYFSCTSAHTCTGDGMAMVTRAGLPLQDLEFVQFHPTGIYGSGCLITEGSRGEGGFLINNKGERFM
ERYAPTAKDLASRDVVSRSMTMEIRAGRGVGPENDHIYLQLSHLPASVLHERLPGISETAAIFAGVDVTKEPIPVIPTVH
YNMGGIPTKYTGEVLTQVDGKDTVVPGLYACGESASVSVHGANRLGANSLLDLVVFGRAVALDIAEKFTPGQAHEPSPAD
IGKESIENLDKLRTATGPRPTADIRLAMQKVMQSDVSVFRTQESLEDGVRRITEVAKTIDEVGTTDRSMIWNSDLVETLE
LQNLLTCAMQTAYSAVARKESRGAHAREDYPERDDENWMKHTLSWQEKESEPIKLTYRDVIYETLDPNECKSVPPGKRVY

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0022900 electron transport chain
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

None predicted.