Protein
MCA_01688_1
Length
941 amino acids
Gene name: MCD4
Description: GPI ethanolamine phosphate transferase 1
Browser: contigA:5186405-5189320-
RNA-seq: read pairs 3706, FPKM 48.6, percentile rank 64.8% (100% = highest expression)
Protein function
| Annotation: | MCD4 | GPI ethanolamine phosphate transferase 1 | |
|---|---|---|---|
| KEGG: | K05285 | PIGN | phosphatidylinositol glycan, class N [EC:2.7.-.-] |
| EGGNOG: | 0PGMQ | MCD4 | Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor |
| SGD closest match: | S000001648 | MCD4 | GPI ethanolamine phosphate transferase 1 |
| CGD closest match: | CAL0000201697 | MCD4 | GPI ethanolamine phosphate transferase 1 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00485_1 | 69.57% | 943 | 0.0 | MIA_00485_1 |
| A0A0J9XAZ0_GEOCN | 63.46% | 947 | 0.0 | Similar to Saccharomyces cerevisiae YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis OS=Geotrichum candidum GN=BN980_GECA07s03090g PE=4 SV=1 |
| A0A161HLJ8_9ASCO | 64.86% | 922 | 0.0 | Mcd4p OS=Sugiyamaella lignohabitans GN=MCD4 PE=4 SV=1 |
| MCD4_YARLI | 62.62% | 947 | 0.0 | GPI ethanolamine phosphate transferase 1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MCD4 PE=3 SV=1 |
| UniRef50_Q6C0Z3 | 62.62% | 947 | 0.0 | GPI ethanolamine phosphate transferase 1 n=9 Tax=Saccharomycetales TaxID=4892 RepID=MCD4_YARLI |
| A0A060T150_BLAAD | 61.95% | 946 | 0.0 | ARAD1C21450p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C21450g PE=4 SV=1 |
| A0A1E3PUH7_9ASCO | 60.63% | 945 | 0.0 | GPI ethanolamine phosphate transferase 1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49251 PE=4 SV=1 |
| MCD4_YEAST | 49.10% | 943 | 0.0 | GPI ethanolamine phosphate transferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCD4 PE=1 SV=1 |
| MCD4_CANAL | 50.26% | 969 | 0.0 | GPI ethanolamine phosphate transferase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MCD4 PE=3 SV=1 |
| A0A1E4TH25_9ASCO | 50.48% | 947 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_25766 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0044
Protein family membership
Domains and repeats
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Domain
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Domain
1
100
200
300
400
500
600
700
800
941
Detailed signature matches
no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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-
NON_CYTOPLASM... (N...)
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-
TRANSMEMBRANE (Tran...)
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cd16020 (GPI_EPT_1)
Residue annotation
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metal binding site...
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putative active si...
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putative substrate...
Protein sequence
>MCA_01688_1 MDYLGKNVVLFVGVLFHIAFLMSIFDIYFVSPLVHGMAHWQSTEQAPAERLFLIVGDGLRADKCFDKLIHPTTGEKEYLA PFIRSKVLSNATFGVSHTRMPTESRPGHVALIAGFYEDVSAVTKGWKENPVDFDSVFNQTRHTYSYGSPDILPMFSRGAS DPDRVDAIMYGHEYEDFTKSSIELDKFVFDHLDDLFDRAKEDKELAAKLRQNKIVFFLHLLGIDTAGHSYRPYSAEYYDN IKYIDQKIKALEQKVESFYNDGKTAWVFTADHGMSDWGSHGDGHPDNTRTPIVAWGAGVPKPITNEKGDHDEFSEPWDLN SVKRNDINQADIASLMAYLVGVNYPSNSVGELPLAFVDASPDVKAKALFANAMAIIEQYKVKESMTANSHIGFQPFPELS DTGKTIQERADKINELISEGKFDKAIESSEELMKAGIKGLRYLQTYNWLLLRTLVTLGYLGWIVYATVSFLHVFVVSGVA EPSHPIVVSTFILILAVLCGLFYQQGVPLNYYLYCVFPVFFWEQIFVNKNTLVTGFTILIKRSHSHSYILFPLLHAVFYV AVMEAIVYGYFYRQVFSVCFALGTVWPWVHNFKTASSNKLLSLSWSVLCLCLATFTLLPANKVEDIPQIAISGGLMAVTG AFFTHNLSKKIPNLSSTPLLVALLQIGIIVITTITTYVSASSLSAKQGLPLYSQICGWTSFLSSLIVPFLQYSSPVSDYR WRLLTLFMAFAPTYVILTISYEGLFYLSFFAILVVWIHLEDAFVKSSDKPVEEPKTKEEKKEQQSITTKEKTLIKSKELT LNEIRLSIFFFYLSQVAFFGTGNIASISSFSLDSVYRLIPIFDPFSMGALLIFKILTPFIILSCTLGILNLKLGLPKSAL FSAVLAVSDILTLNFFYLVVDEGSWLDIGTGISHFSIASLLCLFMMTLEYLSGVLVEGLTI
GO term prediction
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0008152 metabolic process
Molecular Function
GO:0003824 catalytic activity
GO:0016740 transferase activity
Cellular Component
GO:0005789 endoplasmic reticulum membrane