Protein

MCA_01629_1

Length
502 amino acids


Gene name: HSE1

Description: Class E vacuolar protein-sorting machinery protein HSE1

Browser: contigA:5017231-5018881+

RNA-seq: read pairs 5111, FPKM 125.6, percentile rank 82.4% (100% = highest expression)

Protein function

Annotation:HSE1Class E vacuolar protein-sorting machinery protein HSE1
KEGG:K04705STAM signal transducing adaptor molecule
EGGNOG:0PKY6HSE1Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) (By similarity)
SGD closest match:S000000994HSE1Class E vacuolar protein-sorting machinery protein HSE1
CGD closest match:CAL0000197264HSE1Class E vacuolar protein-sorting machinery protein HSE1

Protein alignments

%idAln lengthE-value
MIA_02360_173.83%3860.0MIA_02360_1
A0A060T3N0_BLAAD54.62%3903e-133ARAD1C35112p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C35112g PE=4 SV=1
UniRef50_A0A060T3N054.62%3907e-130ARAD1C35112p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060T3N0_BLAAD
A0A0J9X4Y1_GEOCN53.45%3917e-129Similar to Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins OS=Geotrichum candidum GN=BN980_GECA02s07160g PE=4 SV=1
A0A1E3PI07_9ASCO52.05%3901e-125Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_36054 PE=4 SV=1
HSE1_YARLI47.06%4087e-118Class E vacuolar protein-sorting machinery protein HSE1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=HSE1 PE=3 SV=1
A0A161HJY5_9ASCO46.62%3992e-117ESCRT-0 subunit protein HSE1 OS=Sugiyamaella lignohabitans GN=HSE1 PE=4 SV=1
A0A1E4TI26_9ASCO50.27%3762e-117Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_16116 PE=4 SV=1
HSE1_YEAST39.47%3751e-81Class E vacuolar protein-sorting machinery protein HSE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSE1 PE=1 SV=1
HSE1_CANAL38.44%3852e-77Class E vacuolar protein-sorting machinery protein HSE1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HSE1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3226

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 502

Detailed signature matches

    1. SSF48464 (ENTH/VHS ...)
    1. PS50179 (VHS)
    2. PF00790 (VHS)
    3. SM00288 (VHS_2)
    1. PF00018 (SH3_1)
    2. SM00326 (SH3_2)
    3. SSF50044 (SH3-domain)
    4. PS50002 (SH3)
    5. PR00452 (SH3DOMAIN)
    1. PF03127 (GAT)
    1. SM00726 (uim)
    2. PF02809 (UIM)
    3. PS50330 (UIM)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PR00499 (P67PHOX)
  2. cd11805 (SH3_GRB2_l...)
  3. mobidb-lite (disord...)

Residue annotation

  1. peptide ligand bin...

Protein sequence

>MCA_01629_1
MFRSSAPPSDLEKAIDKAIDPNLTSENWEYIMDVCDKVNDDLENGAKIAVNTIQNRLETTNANQQIYCLKLTSALAQNCG
TKMHRELASQSFTGHLLEMVSESSIHQRVKTTVLELMETLTKEFKGDPSLRQMERSYEIVKNQHPNLQPPEIPQKHQLTA
AERQKEEEDLQLALKLSLQESEPKFSSSSYSSSSNTKPQETFSSSSSSQPQQQQQQQQQKPTETAKGRTAATVNRVRALY
DLTSSDPNELSFRRGDVITVIESVYTDWWKGSLKGQVGIFPLNYVAPIPDPTPEELMQEAKDEAEVFAEAKNIEKLLALL
SSADSNPAANNIAENDEIQRLYKSTQAIRPRLVKLIEKYSQKRDDLIDLDKRFLSSRKTYDQLINTSLSQISSIPQQPNF
SSPPGHYNSMNVNNPYAHSGQPPAMAPSYTGNAPPPAQNYQAPQPTGGNPGYDSSAPSFSSTGAGAIPAMTPTSAPNYQY
QSQPQGSYIPTAGSDLNQPPRY

GO term prediction

Biological Process

GO:0006886 intracellular protein transport

Molecular Function

GO:0005515 protein binding

Cellular Component

GO:0005622 intracellular