Protein

MCA_01623_1

Length
621 amino acids

Gene name: STE7

Description: Serine/threonine-protein kinase Ste7; MAP kinase kinase; in S. cerevisiae involved in pheromone response and in pseudohyphal/invasive growth pathway.

Browser: contigA:5002221-5004087+

RNA-seq: read pairs 1975, FPKM 39.2, percentile rank 59.9% (100% = highest expression)

Protein function

Annotation:STE7Serine/threonine-protein kinase Ste7; MAP kinase kinase; in S. cerevisiae involved in pheromone response and in pseudohyphal/invasive growth pathway.
KEGG:K11226STE7 mitogen-activated protein kinase kinase [EC:2.7.12.2]
EGGNOG:0PFNYSTE7kinase kinase
SGD closest match:S000002318STE7Serine/threonine-protein kinase STE7
CGD closest match:CAL0000197730HST7Serine/threonine-protein kinase STE7 homolog

Protein alignments

%idAln lengthE-value
A0A0J9X4Y3_GEOCN61.17%3764e-160Similar to Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response OS=Geotrichum candidum GN=BN980_GECA02s08040g PE=3 SV=1
MIA_00254_157.91%4301e-155MIA_00254_1
A0A060T1N4_BLAAD55.64%3901e-145ARAD1C26026p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C26026g PE=3 SV=1
A0A161HI58_9ASCO60.19%3092e-130Mitogen-activated protein kinase kinase STE7 OS=Sugiyamaella lignohabitans GN=STE7 PE=4 SV=1
UniRef50_A0A161HI5860.19%3094e-127Mitogen-activated protein kinase kinase STE7 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A161HI58_9ASCO
A0A1E3PSE1_9ASCO47.97%4441e-132Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80911 PE=3 SV=1
A0A1E4TH74_9ASCO55.36%2895e-106Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2795 PE=3 SV=1
STE7_CANAL42.00%3503e-77Serine/threonine-protein kinase STE7 homolog OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HST7 PE=3 SV=2
STE7_YEAST48.58%2822e-77Serine/threonine-protein kinase STE7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STE7 PE=1 SV=1
Q6CET2_YARLI39.66%2951e-66YALI0B13178p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B13178g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9315
Predicted cleavage: 12

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 621

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. SM00220 (serkin_6)
    3. PF00069 (Pkinase)
  3. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  4. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. mobidb-lite (disord...)

Protein sequence

>MCA_01623_1
MIFKNALQKRSASSSSSSTTPSPSVNSPQDTTGSEHAPIIQNLGNSASSSNSLPQKSLRSTSSSSSSSSMSSSHKHSVNL
NHPLPPDPPHISHGSSSHSHHSHSSFESSRQQAYESTYSQLDPNNSKSSSSSYNLNISHSSVSGSNSDLASINSSRSTLS
NRNLNLPSHLASSRSHSSNSIADDSNHTPSRSASHNNLGVSSSSSKSSSKSKPAKLQLPSPDAIPPQVPPKDHPSDAAGL
KLPKSMKRKNFKKLSLGSALSNSSMTPNYTVTTLTEAPATSISNGSTTAKTTVLELQSTNNVVLQAVPVNQGQYASPDSL
IPQMTNLELGVEFQLNIRNEDLQDISSLGSGNGGTVSKALHIPTNRIMARKRIPIEANAEVRRRIVRELHIMHECNSPYI
VSYYGAFVSDNDVVMCMEYMDVGSLDRISKKHGPLPEPIIGKITEAVVEGLVYLYDTHHIMHRDIKPSNVLVNSQGQIKL
CDFGVSGELINSIANTFVGTSIYMSPERIRGGMYNVRSDVWSLGITLLELAIGYFPWENDRDEDGKTKQPMGILDLLQRI
VKEPPPALPDDAPFSNHFRNFVNRCLSEESERPTPQELKNDAFFILSKKNNIRLDKWAQQL

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.