Protein

MCA_01597_1

Length
1,490 amino acids

Gene name: PDR5A

Description: plasma membrane ATP-binding cassette (ABC) transporter; involved in multidrug resistance

Browser: contigA:4933277-4937817+

RNA-seq: read pairs 8063, FPKM 66.8, percentile rank 71.5% (100% = highest expression)

Protein function

Annotation:PDR5Aplasma membrane ATP-binding cassette (ABC) transporter; involved in multidrug resistance
EGGNOG:0PFN7PGUG_04203(ABC) transporter
SGD closest match:S000005679PDR5Pleiotropic ABC efflux transporter of multiple drugs
CGD closest match:CAL0000186516CDR1Pleiotropic ABC efflux transporter of multiple drugs CDR1

Protein alignments

%idAln lengthE-value
MIA_02732_167.68%15070.0MIA_02732_1
A0A0J9XKE4_GEOCN64.29%14870.0Similar to Saccharomyces cerevisiae YDR011W SNQ2 Plasma membrane ATP-binding cassette (ABC) transporter OS=Geotrichum candidum GN=BN980_GECA23s00131g PE=3 SV=1
A0A060T914_BLAAD58.44%14580.0ARAD1D07634p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D07634g PE=3 SV=1
UniRef50_A0A060T91458.44%14580.0ARAD1D07634p n=220 Tax=Dikarya TaxID=451864 RepID=A0A060T914_BLAAD
Q6CET9_YARLI56.43%14230.0YALI0B12980p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12980g PE=3 SV=1
A0A1E4TEV9_9ASCO53.17%15120.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_103973 PE=3 SV=1
A0A161HI40_9ASCO53.03%14840.0ATP-binding cassette multidrug transporter PDR5 OS=Sugiyamaella lignohabitans GN=PDR5 PE=3 SV=1
CDR1_CANAL50.83%15090.0Pleiotropic ABC efflux transporter of multiple drugs CDR1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDR1 PE=1 SV=2
PDR5_YEAST49.70%14910.0Pleiotropic ABC efflux transporter of multiple drugs OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDR5 PE=1 SV=1
A0A1E3PG12_9ASCO41.94%13710.0Plasma membrane ATP-binding cassette transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83866 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2522

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1490

Detailed signature matches

  1. Domain IPR029481
    ABC-transporter extracellular N-terminal domain
    1. PF14510 (ABC_trans_N)
  2. Domain IPR003439
    ABC transporter-like
    1. PF00005 (ABC_tran)
    2. PS50893 (ABC_TRANSP...)
  3. Domain IPR034001
    ATP-binding cassette transporter, PDR-like subfamily G, domain 1
    1. cd03233 (ABCG_PDR_d...)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
  6. Domain IPR013525
    ABC-2 type transporter
    1. PF01061 (ABC2_membrane)
  7. Domain IPR010929
    CDR ABC transporter
    1. PF06422 (PDR_CDR)
  8. Domain IPR034003
    ATP-binding cassette transporter, PDR-like subfamily G, domain 2
    1. cd03232 (ABCG_PDR_d...)
  9. SITE IPR017871
    ABC transporter, conserved site
    1. PS00211 (ABC_TRANSP...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.40.50...
  3. NON_CYTOPLASM... (N...)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)
  6. mobidb-lite (disord...)

Protein sequence

>MCA_01597_1
MSSESPKSFYRDEDTSSTSSSMQKEKHDQEILELARQFTNQANQNQQHVQDESGDPEKYFEPLSRRISRATSIVSVSTAV
NPFIDAQDTILDPYNERFNARQWTKHMLKLQQKDPERYPLRTAGVSFKNLSAYGYSQGSDYQKTVGNIVLSLGSMTRSLM
GHKGDHVDILRNFNGLLKEGETCVVLGRPGSGCTTLLKSIAGDTYGFYLTEDSNINYQGLTPEDIKKSFRGEVIYNAETE
VHFPKLTVGDTLKFAALARTPENRLPGVTREAHATHLRDVIMASFGLLHTTNTIVGDDYTRGVSGGERKRVSIAEVLLAG
ATLQCWDNSTRGLDSATALEFIRNLKISSDLNGASMFVSLYQASQEMYDQFDKVTVLYLGRQIYFGPASKAKEYFERMGY
ICADRQTTGDFLTSLTSPSERIIKPGYEDKVPRTPDQFREYWENSPEFKELIQEIDEWNQQHAPGGASYEQFVRSRQANK
AKGVREKSSFTISFGMQVKLCMWRGFLRIKGDPAVTISSILGNTFIGLVVSSIFYNLPQTTGSYYYRCAALFFSILSNAM
ASGLEILTLYAQRPIIEKHARYAFYHPSAEAVSSIICDLPAKILTSIAFNLVLYFMVNLRRTPAAFFTFYLFSFICTLVM
SAIFRTIASVSRSISEALTPASLMILMLVTTTGFVIPVVDMHPWFRWINYINPIAYSFESLMINEFRNRIFLCSDIIPSG
SYYDNVSLADKACNIVGGLPWDGVSDVLYGSGTEYIELSFKYYINHIWRNLGIIIAFGVFFYSTYFFFAEIVSAQRSKGE
ILLFQRGFVPPKHKDEEAMAEAHQSAIAPQPTQEEVNLLKQEGIFAWKDVCYDIKIKGEPRRLLDHVDGWVQPGTLTALM
GASGAGKTTLLDTLADRVTMGVVTGEMLVNGRRRDQSFQRKTGYVQQQDVHLATSTVREALEFSALLRQPAKYTKEEKLA
YVDEVIRILEMEEYSDAIVGVPGEGLNVEQRKRLTIGVELAARPELLLFLDEPTSGLDSQTAWSIMMLMKKLTNSGQAIL
CTIHQPSAILFQQFDRLLLLKRGGQTVFYGDLGENASRMISYFERNGAPPCPPDANPAEWMLHAIGAAPGSHTDQDWHEV
WKNSPEYREMREEMDEIISGFGPIQTLDSQAKQENVLQFATPLWKQTLIVTKRVFQQYWRTPSYIYAKAAMCIVSPLFIG
FTFYKAKNNIQGMQNQMYAIFMFLVIFGTLAQQIMPHFVTQRTLYETRERPSKTYSWVAFIISNLVVEIPWQILMAVFSF
FCIYYPIGFYNNASAADATAERGAAFFMMVVVFYVFTSTFAHMVVAGVDDADTAANFSNLLFMMCLFFCGVLAGPDALPG
FWIFMYRVSPMTYIVGTFMSTGLAGNVIKCSEKELTSIVIPDNMNVTCAEYMAQTLELRGGSITDPTATDVCKYCSIATT
DDYLATISAPVSEAWRNFGLIFVYIAFNCVACCFLYWLIRVPKKSKKKED

GO term prediction

Biological Process

GO:0006810 transport

Molecular Function

GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances

Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane