Protein

MCA_01551_1

Length
633 amino acids

Gene name: DED1

Description: ATP-dependent RNA helicase DED1

Browser: contigA:4783924-4785826+

RNA-seq: read pairs 6035, FPKM 117.6, percentile rank 81.5% (100% = highest expression)

Protein function

Annotation:DED1ATP-dependent RNA helicase DED1
KEGG:K11594DDX3X ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
EGGNOG:0PFY4DED1ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity)
SGD closest match:S000005730DED1ATP-dependent RNA helicase DED1
CGD closest match:CAL0000190729DED1ATP-dependent RNA helicase DED1

Protein alignments

%idAln lengthE-value
MIA_03578_184.02%4880.0MIA_03578_1
A0A0J9X3H6_GEOCN80.82%4850.0Similar to Saccharomyces cerevisiae YPL119C DBP1 Putative ATP-dependent RNA helicase of the DEAD-box protein family OS=Geotrichum candidum GN=BN980_GECA01s09756g PE=3 SV=1
A0A167DQH5_9ASCO79.78%4500.0Putative DEAD-box ATP-dependent RNA helicase DBP1 OS=Sugiyamaella lignohabitans GN=DBP1 PE=3 SV=1
A0A060TIN1_BLAAD76.68%4760.0ARAD1D47806p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D47806g PE=3 SV=1
DED1_YARLI74.54%4870.0ATP-dependent RNA helicase DED1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=DED1 PE=3 SV=1
A0A1E3PR66_9ASCO78.37%4530.0ATP-dependent RNA helicase DED1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_20851 PE=3 SV=1
UniRef50_B8MK9478.98%4520.0ATP dependent RNA helicase (Dbp1), putative n=17 Tax=Eukaryota TaxID=2759 RepID=B8MK94_TALSN
DED1_CANAL74.24%4580.0ATP-dependent RNA helicase DED1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DED1 PE=3 SV=1
A0A1E4TEK2_9ASCO72.77%4810.0Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_11709 PE=3 SV=1
DED1_YEAST70.82%4730.0ATP-dependent RNA helicase DED1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DED1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0089
Predicted cleavage: 33

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 633

Detailed signature matches

  1. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. SITE IPR000629
    ATP-dependent RNA helicase DEAD-box, conserved site
    1. PS00039 (DEAD_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd00079 (HELICc)
  4. cd00268 (DEADc)
  5. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg++ binding site ...
  3. motif III cd00268
  4. nucleotide binding...
  5. ATP-binding site c...

Protein sequence

>MCA_01551_1
MSNTSNDAAPVSAPLNGNNNAQPSTYVPPHRARGEYVPPAQNEGGYKKYNNYNNNNGGGFSGGYRNQRYNNNGGYNNYRN
NNNGYNNGGGYRNGGGYNNYRGGQRDNNYRNPMSGNFRDGKHIPGPADPRAEVELFGTKDDPSFQSTGINFDNYDDIPVE
ATGTDVPEPVTVFGPPLEEHLITNITLARYSKPTPVQKYSIPIVASGRDLMACAQTGSGKTGGFLFPILSESFLKGPAPV
PETTNSYMKKGYPTSLVLAPTRELVSQIYDEAKKFAYRSWVRPCVVYGGSDINAQIRQIERGCDLLVATPGRLVDLLERR
KISLQNIKFLVLDEADRMLDMGFEPQIRRIVEGEDMTSVQDRQTLMFSATFPRDIQMLARDFLKDYIFLSVGRVGSTSEN
ITQRVMYVEDDEKRSALLDILSSGDQGLTLVFVETKRMADALCDFLMSQNFPATAIHGDRTQRERERALEQFRNGSTPIM
VATAVASRGLDIPNVKHVVNYDLPTDIDDYVHRIGRTGRAGNTGTATSFFNRNNKNVVRDLIEILKEANQEVPSFLDTVQ
REAAYGKSKGRGGMRNNGPSHDFRKFNGGLDKYSGSIHHDRPPQQSYQSGGYGNNGGGYYGNQGSSYGGYNNW

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.