Protein

MCA_01548_1

Length
569 amino acids

Gene name: ASN1

Description: Asparagine synthase (Glutamine-hydrolyzing) 2

Browser: contigA:4774863-4776573+

RNA-seq: read pairs 10760, FPKM 233.2, percentile rank 89.8% (100% = highest expression)

Protein function

Annotation:ASN1Asparagine synthase (Glutamine-hydrolyzing) 2
KEGG:K01953asnB asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
EGGNOG:0PH2VASN1Asparagine synthetase
SGD closest match:S000003356ASN2Asparagine synthetase [glutamine-hydrolyzing] 2
CGD closest match:CAL0000188342ASN1Asparagine synthase (Glutamine-hydrolyzing) 2

Protein alignments

%idAln lengthE-value
MIA_06044_186.80%5680.0MIA_06044_1
A0A0J9X392_GEOCN84.19%5630.0Similar to Saccharomyces cerevisiae YPR145W ASN1 Asparagine synthetase OS=Geotrichum candidum GN=BN980_GECA01s02067g PE=4 SV=1
A0A1E3PJ94_9ASCO76.91%5630.0Glutamine-hydrolyzing asparagine synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83114 PE=4 SV=1
Q6CH25_YARLI78.43%5610.0YALI0A13387p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A13387g PE=4 SV=1
A0A161HHN7_9ASCO78.05%5650.0Asparagine synthase (Glutamine-hydrolyzing) 2 OS=Sugiyamaella lignohabitans GN=ASN2 PE=4 SV=1
A0A060T0S8_BLAAD76.64%5650.0ARAD1C15356p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C15356g PE=4 SV=1
A0A1D8PIB2_CANAL74.08%5710.0Asparagine synthase (Glutamine-hydrolyzing) 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ASN1 PE=4 SV=1
ASNS2_YEAST73.51%5700.0Asparagine synthetase [glutamine-hydrolyzing] 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ASN2 PE=1 SV=2
UniRef50_P4909073.51%5700.0Asparagine synthetase [glutamine-hydrolyzing] 2 n=438 Tax=Eukaryota TaxID=2759 RepID=ASNS2_YEAST
A0A1E4THX9_9ASCO70.43%5750.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26824 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0117

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 569

Detailed signature matches

  1. Family IPR006426
    Asparagine synthase, glutamine-hydrolyzing
    1. PIRSF001589 (Asn_sy...)
    2. TIGR01536
  2. Domain IPR029055
    Nucleophile aminohydrolases, N-terminal
    1. G3DSA:3.60.20.10
    2. SSF56235 (N-termina...)
  3. Domain IPR017932
    Glutamine amidotransferase type 2 domain
    1. PF13537 (GATase_7)
    2. PS51278 (GATASE_TYPE_2)
  4. Domain IPR033738
    Asparagine synthase, N-terminal domain
    1. cd00712 (AsnB)
  5. Domain IPR014729
    Rossmann-like alpha/beta/alpha sandwich fold
    1. G3DSA:3.40.50...
  6. Domain IPR001962
    Asparagine synthase
    1. PF00733 (Asn_synthase)
    2. cd01991 (Asn_Syntha...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF52402 (Adenine n...)

Residue annotation

  1. active site cd00712
  2. dimer interface cd...
  3. Molecular Tunnel c...
  4. Ligand Binding Sit...

Protein sequence

>MCA_01548_1
MCGICAFFRHPDVENFKEHALILSKRIRHRGPDWSGNIIKNSTILLHERLSIVGVDSGAQPITNADESIILAVNGEIYNH
RIIRKDFPDYPFKTHSDCEPIIPLYEKYGVDLPKYLDGMFAFVLYDVKKDRVIAARDPIGITTLYMGKNKKSPKTRAFAS
ELKCLVDDCDEIVAFPPGHIYDSETDSTTRYYTPSWWDAEKIPTKPADLKLIRETLEKSVRKRLMSEVPYGVLLSGGLDS
SLIASIAARETSKALADNPVKHSLAGIDEAGTLVNTSGSRLHSFAIGLPGAPDLKAAQKVAEFIGTIHHEHTFTLEEGLD
ALKDVIWHLETFDVTTIRASTPMYLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFANAPSSDEFHKETVQRVKNLHLSDCL
RANKSTMAWGLEARVPFLDKEFLDVCMSIDPKDKMITKDHIEKYILRKAFDTKDEEGATPYLPDEILWRQKEQFSDGVGY
SWIDGLKDAAEAKISDEQFKIAKPEWGDDIPTTKEAYWYRLMFDELFPTKTAAETVMRWIPKADWGCHADPSGRYAKIHE
ASVLDGEKK

GO term prediction

Biological Process

GO:0006529 asparagine biosynthetic process

Molecular Function

GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity

Cellular Component

None predicted.