Protein

MCA_01509_1

Length
502 amino acids

Gene name: LPD1A

Description: Dihydrolipoyl dehydrogenase, mitochondrial

Browser: contigA:4675653-4677766-

RNA-seq: read pairs 21626, FPKM 531.2, percentile rank 94.4% (100% = highest expression)

Protein function

Annotation:LPD1ADihydrolipoyl dehydrogenase, mitochondrial
KEGG:K00382DLD dihydrolipoamide dehydrogenase [EC:1.8.1.4]
EGGNOG:0PGM9LPD1dihydrolipoyl dehydrogenase
SGD closest match:S000001876LPD1Dihydrolipoyl dehydrogenase, mitochondrial
CGD closest match:CAL0000188240LPD1Dihydrolipoyl dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_02783_185.66%5020.0MIA_02783_1
A0A0J9XDH1_GEOCN84.60%5000.0Dihydrolipoyl dehydrogenase OS=Geotrichum candidum GN=BN980_GECA09s01165g PE=3 SV=1
A0A060T641_BLAAD79.00%5000.0Dihydrolipoyl dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08162g PE=3 SV=1
A0A1E3PTI8_9ASCO74.55%5030.0Dihydrolipoyl dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81186 PE=3 SV=1
Q6C8C6_YARLI73.51%5020.0Dihydrolipoyl dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D20768g PE=3 SV=1
UniRef50_A0A0H5C0B676.05%4760.0Dihydrolipoyl dehydrogenase n=1 Tax=Cyberlindnera jadinii TaxID=4903 RepID=A0A0H5C0B6_CYBJA
A0A1E4TJ44_9ASCO75.58%4750.0Dihydrolipoyl dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_55562 PE=3 SV=1
Q59RQ6_CANAL74.12%4520.0Dihydrolipoyl dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LPD1 PE=3 SV=1
DLDH_YEAST70.96%4580.0Dihydrolipoyl dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LPD1 PE=1 SV=1
A0A161HGG0_9ASCO78.65%3840.0Dihydrolipoyl dehydrogenase OS=Sugiyamaella lignohabitans GN=LPD1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9915
Predicted cleavage: 31

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 502

Detailed signature matches

  1. Family IPR006258
    Dihydrolipoamide dehydrogenase
    1. TIGR01350
  2. Domain IPR023753
    FAD/NAD(P)-binding domain
    1. PF07992 (Pyr_redox_2)
    2. G3DSA:3.50.50.60
    3. SSF51905 (FAD/NAD(P...)
  3. Domain IPR016156
    FAD/NAD-linked reductase, dimerisation domain
    1. SSF55424 (FAD/NAD-l...)
    2. G3DSA:3.30.39...
  4. Domain IPR004099
    Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
    1. PF02852 (Pyr_redox_dim)
  5. SITE IPR012999
    Pyridine nucleotide-disulphide oxidoreductase, class I, active site
    1. PS00076 (PYRIDINE_R...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. PIRSF000350 (Hg-II_...)
  3. PR00368 (FADPNR)
  4. PR00411 (PNDRDTASEI)
  5. SFLDG00296 (disulfi...)

Residue annotation

  1. SFLDG00296

Protein sequence

>MCA_01509_1
MLSRTFLRAPKLQKAGITRLNVTATTFVRGMASDAGEHDVVVIGGGPGGYVAAIKAAQLGLKTACIEKRGRLGGTCLNVG
CIPSKSLLNNSHLYHQIVHDTKKRGIIVSDVKVDIDGIQKAKEDSVIGLTKGIEILFKQNKVDYYKGTGSFVSEHEIKVD
PIEGGEAATLKAKNIIIATGSEATPFPGIEIDEERIVTSTGALALKEVPKRFAIIGGGIIGLEMGSVWSRLGSEVTVIEF
QNAIGAGMDGEVAKNTQKILGKQGLKFKTGTKVLTATRNGEVVDIEVENVKSGKKESLQADVLLVAVGRRPYTQGLGLEK
LGIDVDEKGRVVMDQEYRTKFPHIRVIGDVTYGPMLAHKAEDEGIAAVEYIKHGHGHVNYDAIPSVMYSHPEVAWVGKNE
EQLKAEGVKYNVGKFPFLANSRAKTNLDTEGFVKFISDKETDRILGVHIIGPNAGEMIAEAVLAVEYGASSEDVARTCHA
HPTLSEAFKEAAMAAYNKAIHF

GO term prediction

Biological Process

GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004148 dihydrolipoyl dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

None predicted.