MCA_01413_1

Protein

Length

368 amino acids

RNA-seq: read pairs 2268, FPKM 75.9, percentile rank 74.3% (100% = highest expression)

Protein function

KEGG:	K00062	E1.1.1.116	D-arabinose 1-dehydrogenase [EC:1.1.1.116]
EGGNOG:	0PKGN	PGUG_03654	L-galactose dehydrogenase
SGD closest match:	S000004644	ARA2	D-arabinose 1-dehydrogenase
CGD closest match:	CAL0000175239	orf19.5665	D-arabinose 1-dehydrogenase (NAD(P)(+))

Protein alignments

	%id	Aln length	E-value
MIA_02468_1	61.22%	361	1e-157	MIA_02468_1
A0A0J9XB18_GEOCN	52.49%	362	9e-126	Similar to Saccharomyces cerevisiae YMR041C ARA2 NAD-dependent arabinose dehydrogenase OS=Geotrichum candidum GN=BN980_GECA07s05367g PE=4 SV=1
A0A167EW31_9ASCO	50.00%	358	4e-116	D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2 OS=Sugiyamaella lignohabitans GN=ARA2 PE=4 SV=1
A0A1E3PH73_9ASCO	49.28%	347	8e-107	Aldo/keto reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_26715 PE=4 SV=1
A0A060T7M2_BLAAD	43.92%	362	5e-101	ARAD1C22990p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C22990g PE=4 SV=1
UniRef50_A0A060T7M2	43.92%	362	1e-97	ARAD1C22990p n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A060T7M2_BLAAD
Q6BZU5_YARLI	42.66%	354	1e-89	YALI0F30811p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F30811g PE=4 SV=1
A0A1D8PL15_CANAL	44.54%	339	3e-87	D-arabinose 1-dehydrogenase (NAD(P)(+)) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5665 PE=4 SV=1
A0A1E4TAV0_9ASCO	41.79%	335	3e-80	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148385 PE=4 SV=1
ARA2_YEAST	42.15%	344	3e-79	D-arabinose 1-dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARA2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0205

Protein family membership

Aldo/keto reductase (IPR020471)

Domains and repeats

Domain
19 - 340
NADP-dependent oxidoreductase domain (IPR023210)

1 50 100 150 200 250 300 368

Detailed signature matches

IPR020471

Aldo/keto reductase
1. PR00069 (ALDKETRDTASE)
  
  56 - 80
  
  PRINTS
  PR00069 (ALDKETRDTASE)
  
  120 - 138
  
  PRINTS
  PR00069 (ALDKETRDTASE)
  
  153 - 170
  
  PRINTS
  PR00069 (ALDKETRDTASE)
IPR023210

NADP-dependent oxidoreductase domain
1. SSF51430 (NAD(P)-li...)
  
  26 - 336
  
  SUPERFAMILY
  SSF51430 (NAD(P)-linked oxidoreductase)
2. cd06660 (Aldo_ket_red)
  
  26 - 318
  
  CDD
  cd06660 (Aldo_ket_red)
3. PF00248 (Aldo_ket_red)
  
  28 - 318
  
  Pfam
  PF00248 (Aldo_ket_red)
4. G3DSA:3.20.20...
  
  19 - 340
  
  GENE3D
  G3DSA:3.20.20.100 (G3DSA:3.20.20.100)

no IPR

Unintegrated signatures

mobidb-lite (disord...)

1 - 20

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

active site cd06660

32G

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

33A

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

34G

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

65D

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

70Y

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

98K

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

136H

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

137D

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

168S

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

169G

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

194L

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

231A

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

232S

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

233P

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

234L

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

235S

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

236M

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

275A

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

299L

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

300P

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

304G

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

305L

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

310E

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

313N

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)

314A

active site
32G, 33A, 34G, 65D, 70Y, 98K, 136H, 137D, 168S, 169G, 194L, 231A, 232S, 233P, 234L, 235S, 236M, 275A, 299L, 300P, 304G, 305L, 310E, 313N, 314A
CDD
cd06660 (Aldo_ket_red)
catalytic tetrad c...

65D

catalytic tetrad
65D, 70Y, 98K, 136H
CDD
cd06660 (Aldo_ket_red)

70Y

catalytic tetrad
65D, 70Y, 98K, 136H
CDD
cd06660 (Aldo_ket_red)

98K

catalytic tetrad
65D, 70Y, 98K, 136H
CDD
cd06660 (Aldo_ket_red)

136H

catalytic tetrad
65D, 70Y, 98K, 136H
CDD
cd06660 (Aldo_ket_red)

Protein sequence

>MCA_01413_1
MSKESLKPIPTNINNSSPEKKEISDIPPIILGAGVFNYQYNDDPNSMPAEAILSRAFDLGIRAIDSSSYYGPSEIIVGNA
LNNIKDKYPRNSYMIFTKCGRVTESEFDYDPDHIEASVRRSLERFHTTYLDVVYLHDVEFMPLSASIAALTRLQQLKQQG
LISYVGLSGYPVDYLLKVSSKFAQKFGSPLDLVLSYSNFCIQNTLLKDYVPKFFDSNVSNGGAGLKCLVAASPLSMGLIR
SQPAPSFHPASKDLKDAIHKAAEYTKENGGGVDLADLAVRFALRNWWQVRKNSDSKTVLPFVYGLSSIKEVENAVKIYWQ
VQDLSNPENQKLYEQDQKLTQKVQEILGSHLNETWPSGINHDNDDDEE

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features