Protein

MCA_01329_1

Length
342 amino acids

Gene name: URA6B

Description: uridylate kinase

Browser: contigA:4163817-4165048-

RNA-seq: read pairs 5256, FPKM 189.3, percentile rank 87.4% (100% = highest expression)

Protein function

Annotation:URA6Buridylate kinase
KEGG:K13800CMPK1 UMP-CMP kinase [EC:2.7.4.- 2.7.4.14]
EGGNOG:0PG3GPGUG_03601Uridylate kinase
SGD closest match:S000001507URA6Uridylate kinase
CGD closest match:CAL0000189392URA6Uridylate kinase

Protein alignments

%idAln lengthE-value
MIA_04688_173.68%2479e-121MIA_04688_1
A0A0J9XD76_GEOCN62.96%2438e-102Uridylate kinase OS=Geotrichum candidum GN=URA6 PE=3 SV=1
KCY_YEAST72.02%1931e-100Uridylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA6 PE=1 SV=1
UniRef50_P1570072.02%1933e-97Uridylate kinase n=89 Tax=Eukaryota TaxID=2759 RepID=KCY_YEAST
A0A060T2Q3_BLAAD61.09%2211e-91Uridylate kinase OS=Blastobotrys adeninivorans GN=URA6 PE=3 SV=1
Q6C2B0_YARLI69.95%1933e-92Uridylate kinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=URA6 PE=3 SV=1
A0A167CX39_9ASCO66.67%1921e-87Uridylate kinase OS=Sugiyamaella lignohabitans GN=URA6 PE=3 SV=1
Q59KZ3_CANAL66.49%1946e-87Uridylate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA6 PE=3 SV=1
A0A1E4TD72_9ASCO64.92%1914e-88Uridylate kinase OS=Tortispora caseinolytica NRRL Y-17796 GN=URA6 PE=3 SV=1
A0A1E3PGZ3_9ASCO65.10%1924e-85Uridylate kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=URA6 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9900
Predicted cleavage: 62

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 342

Detailed signature matches

  1. Family IPR000850
    Adenylate kinase/UMP-CMP kinase
    1. PR00094 (ADENYLTKNASE)
    2. MF_00235 (Adenylate...)
    3. cd01428 (ADK)
  2. Family IPR006266
    UMP-CMP kinase
    1. MF_03172 (Adenylate...)
    2. TIGR01359
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. SITE IPR033690
    Adenylate kinase, conserved site
    1. PS00113 (ADENYLATE_...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.40.50...
  3. NON_CYTOPLASM... (N...)
  4. PF00406 (ADK)
  5. TMhelix
  6. TRANSMEMBRANE (Tran...)
  7. mobidb-lite (disord...)

Residue annotation

  1. AMP-binding site c...
  2. ATP-AMP (Ap5A)-bin...

Protein sequence

>MCA_01329_1
MFHSTRLIRAVRPAVGMKSLVGKSQLQILGFNKNLISNKSIQFRQSVPVSNFLLGRSIRSYSTDQNPAKPVRPVRPTIGT
KPKTEEEKEAEEKQKAIHRGRTRLKIFIILGALAGATSLLSSYFGQERVPEPSIDTVFMPVPKRAFPEGQVSVIFVLGGP
GAGKGTQCAKLVEDYQFVHLSAGDLLRAEQAREGSQYGELIDEYIRTGQIVPQEITIALLENAMKDSVKQGKNKFLIDGF
PRKMDQAVKFEEEVAESKMVLFLDAPEDIMLQRLLKRGETSGRTDDNIESIKKRFTTFKETSMPVVEYFEKQNKVARVPT
NQSIDDVYADVKKSLKEYKVIE

GO term prediction

Biological Process

GO:0006139 nucleobase-containing compound metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process

Molecular Function

GO:0004127 cytidylate kinase activity
GO:0005524 ATP binding
GO:0009041 uridylate kinase activity
GO:0019205 nucleobase-containing compound kinase activity

Cellular Component

None predicted.