Protein

MCA_01285_1

Length
409 amino acids

Gene name: ERG10B

Description: Acetyl-CoA acetyltransferase

Browser: contigA:4040145-4041375-

RNA-seq: read pairs 2629, FPKM 79.2, percentile rank 75.1% (100% = highest expression)

Protein function

Annotation:ERG10BAcetyl-CoA acetyltransferase
KEGG:K00626E2.3.1.9 acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
EGGNOG:0PG5VFG05087.1Acetyl-CoA acetyltransferase
SGD closest match:S000005949ERG10Acetyl-CoA acetyltransferase
CGD closest match:CAL0000184591ERG10Acetyl-CoA C-acetyltransferase

Protein alignments

%idAln lengthE-value
MIA_05667_179.17%4080.0MIA_05667_1
A0A0J9XCR6_GEOCN73.53%4080.0Similar to Saccharomyces cerevisiae YPL028W ERG10 Acetyl-CoA C-acetyltransferase (Acetoacetyl-CoA thiolase) OS=Geotrichum candidum GN=BN980_GECA09s03409g PE=3 SV=1
A0A167EG32_9ASCO69.19%4090.0Acetyl-CoA C-acetyltransferase OS=Sugiyamaella lignohabitans GN=ERG10 PE=3 SV=1
UniRef50_A0A167EG3269.19%4090.0Acetyl-CoA C-acetyltransferase n=3 Tax=saccharomyceta TaxID=716545 RepID=A0A167EG32_9ASCO
A0A1E3PQL0_9ASCO64.48%4110.0Acetoacetyl-CoA thiolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80891 PE=3 SV=1
A0A060T7Y3_BLAAD67.59%3980.0ARAD1D02992p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D02992g PE=3 SV=1
THIL_YARLI67.17%3960.0Acetyl-CoA acetyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PAT1 PE=3 SV=1
A0A1E4TJA4_9ASCO60.79%4031e-167Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_76352 PE=3 SV=1
A0A1D8PH52_CANAL52.42%3931e-124Acetyl-CoA C-acetyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG10 PE=3 SV=1
THIL_YEAST50.25%3963e-118Acetyl-CoA acetyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG10 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9572
Predicted cleavage: 17

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 409

Detailed signature matches

  1. Family IPR002155
    Thiolase
    1. TIGR01930
    2. cd00751 (thiolase)
    3. PIRSF000429 (Ac-CoA...)
  2. Domain IPR016039
    Thiolase-like
    1. SSF53901 (Thiolase-...)
    2. G3DSA:3.40.47.10
  3. Domain IPR020616
    Thiolase, N-terminal
    1. PF00108 (Thiolase_N)
  4. Domain IPR020617
    Thiolase, C-terminal
    1. PF02803 (Thiolase_C)
  5. SITE IPR020615
    Thiolase, acyl-enzyme intermediate active site
    1. PS00098 (THIOLASE_1)
  6. SITE IPR020613
    Thiolase, conserved site
    1. PS00737 (THIOLASE_2)
  7. SITE IPR020610
    Thiolase, active site
    1. PS00099 (THIOLASE_3)

Residue annotation

  1. dimer interface cd...
  2. active site cd00751

Protein sequence

>MCA_01285_1
MSRVFFRNFSVSTVRNLEKAYIVAAGRSPIANFNGSLKSVQATDLGAQVVKAVVERANIKPADVDEAYLGMVLQGSVGQS
PARQIVIKAGLPDTVDATTVNKVCASGLKSVALATQSIWLGDAGVVLAGGAESMSNSPYYLPRNGLGFGDVPAKDSIILD
GLTDVYNKIHMGNCCENTNKRENITREDQDEFALESYRRSLESIKSGAFKDEIVPITVKSRKGETVFSEDEGPASAKLDK
LKSLRPAFQKENGTVTAGNASALNDGAAALVLASGTKAKELNTPVLAKVIAYADAATAPIDFTIAPSLAIPKLLKKAGLT
VDDIARWELNEAFSGVSIANNRRLGLDPAKVNVKGGAVALGHPIGASGARIVVTLINNLKEGEYGVAAICNGGGAATSLL
IQKVSSVDA

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.